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26 results on '"Smith, C.R."'

4. Partial Synthesis of Harringtonine Analogs

Author

Mikolajczak, K.L., Smith, C.R., and Powell, R.G.

Abstract

Three analogs of harringtonine (II), an ester alkaloid which is active in the P-388 experimental leukemia system, were prepared by acylating cephalotaxine (I). They were the 2-hydroxy-2-methylbutyryl (III), 2-carbomethoxymethyl-5-methylhexanoyl (IXc, and 2-carbomethoxymethylene-5-methylhexanoyl VIId) esters of I. A special sequence was developed for the synthesis of III. All of these harringtonine analogs, with the possible exception of III, are inactive in the P-388 system. In addition, data are presented which show that a rearranged harringtonine isomer (X) also is inactive. These results emphasize some highly specific structural requirements for antitumor activity of Cephalotaxusalkaloids.

Published
1974
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5. Antitumor Alkaloids from Cephalotaxus harringtonia: Structure and Activity

Author

Powell, R.G., Weisleder, D., and Smith, C.R.

Abstract

Cephalotaxine and several of its esters were isolated from Cephalotaxus harringtoniaK. Koch var. harringtonia.Although cephalotaxine is inactive, harringtonine, isoharringtonine, homoharringtonine, and deoxyharringtonine have shown significant activity against experimental P388 leukemia and against L-1210 leukemia in mice.

Published
1972
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6. California. Bridgeport quadrangle (30'), 1911 (1939)

Author

Sylvester, A.H., surveyor; Weston, C.M., surveyor; Smith, C.R., surveyor, Sylvester, A.H., topographer; Davis, George R., topographer; Chapman, Pearson, topographer, Sylvester, A.H., surveyor; Weston, C.M., surveyor; Smith, C.R., surveyor, and Sylvester, A.H., topographer; Davis, George R., topographer; Chapman, Pearson, topographer

Abstract

R.B. Marshall, Chief Geographer. E.M. Douglas and T.G. Gerdine, Geographers in charge. Topography by A.H. Sylvester, Geo. R. Davis and Pearson Chapman. Control by A.H. Sylvester, C.M. Weston and C.R. Smith. Surveyed in 1905-1909.

Published
1911

14. Synthesis of deoxyharringtonine

Author

Mikolajczak, K.L., primary, Smith, C.R., additional, Weisleder, D., additional, Kelly, T.Ross, additional, McKenna, J.C., additional, and Christenson, P.A., additional

Published
1974
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