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A study was made of the serum insulin level after the intravenous administration of glucose (0.33 gm/ kg) in two groups of normal subjects—18 in the 60–85 age bracket, and 16 in the 23–45 age bracket. All had a normal coefficient of glucose utilization and a normal blood glucose curve after intravenous administration of glucose. Serum insulin was assayed by the radio‐immunological method, with use of an ion exchange resin. Blood samples were drawn at 2, 5, 10, 30, 45 and 60 minutes after the end of the glucose infusion.

IT is a well-established fact that chlorothiazide potentiates the hypotensive effects of ganglion-blocking agents1–2. However, the way this potentiation is brought about is not clear. It has been thought that chlorothiazide acts either by a direct hypotensive action2, or by sodium depletion3, or by reduction in plasma-volume3, or as in the case of mecamilamine and possibly of pempidine, by a reduction in renal excretion4of the ganglion-blocking agents. From a pharmacological view-point there is a good deal of similarity between the neuromuscular junction and the gangliarsynapsis.