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It is reported on alterations of ECG and blood pressure appearing in 51 patients during endoscopic examination of the stomach. Above all, these alterations consisted of repolarisation disturbances with a partial preterminal negative T and isolated supraventricular extrasystoles. Atrioventricular blocks or spreading of the QRS-complex were not observed. In all patients a distinct increase in frequency was present while the endoscope was introduced. Since regression of all these alterations would occur after examination, a vegetative-functional stimulus might be the inducing factor. In endoscopic examinations the risk of any incidents appearing in connection with the system of coronary circulation is minimal. In patients with considerable previous damage of the heart caution is advised.