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ConclusionThe rapid intravenous injection of gases or mineral oil in sufficient quantities to replace blood in the right ventricle of dogs will cause the reduction or loss of the initial ventricular deflection of the electrocardiogram in direct leads from the epicardial surface of the right ventricle.

Respiratory factors that might be responsible for the appearance of cardiac arrhythmias during cyclopropane anesthesia were studied in 34 patients. Respiration was controlled manually in 15 cases and mechanically in 14; in 5 the control was manual in the beginning and mechanical later on. In the presence of such control, high blood levels of cyclopropane were quite compatible with adequate oxygenation as gauged by determinations of oxygen saturation, carbon dioxide tension, and pH. Electrocardiographic changes, interpreted as a shifting of the pacemaker toward the atrioventricular node, occurred repeatedly in five cases but were not associated with any noticeable cardiac irregularity. Distinctly palpable arrhythmias occurred in two patients; in one of these spontaneous respiration had been permitted early in the anesthesia and in the other there were indications of underlying cardiovascular instability. Under the conditions of this study hyperventilation was more frequent than hypoventilation. The evidence showed that cardiac arrhythmias perceptible by palpation should rarely occur when cyclopropane is administered with ventilatory control.

Relatively few pneumonectomies have been performed in women in the childbearing age, the majority of such operative procedures being carried out for pulmonary cancer which occurs most often in men over 40. 1 Because pregnancy following pneumonectomy has not previously been reported, we are reporting the case of a patient who was delivered of a full term infant two years after such an operation. The physiologic changes which occurred incident to the pregnancy, the increased oxygen demand, the increased blood volume and the increased work load on the heart were adequately handled by the cardiovascular and respiratory systems despite a reduction in the size of the pulmonary capillary bed by at least 50 per cent and a loss of more than half the lung parenchyma. REPORT OF CASE Mrs. M. O., a white primigravida aged 40, had had her right lung removed at the age of 37 because of grade