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3. PANEL DISCUSSION

Author

Ross, Gordon, primary, Chidsey, Charles A., additional, Goldberg, Leon I., additional, and Pitt, Bertram, additional

Published
1970
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6. Regional myocardial blood flow in the dog studied with radioactive microspheres1.

Author

Fortuin, Nicholas J., Kaihara, Shigekoto, Becker, Lewis C., and Pitt, Bertram

Abstract

Regional myocardial blood flow was studied in the anaesthetized dog by determining the distribution of 15 and 50μ radioactive microspheres after left atrial injection. Doses of the 15μ spheres below 4 × 106 did not significantly alter coronary or systemic haemodynamics. Larger doses produced a significant increase in mean aortic pressure. Less than 1% of the 15μ spheres delivered to the heart passed into the coronary sinus. The myocardial distribution of 15 and 50μ spheres was not significantly different except for the ratio of left ventricular endocardium to epicardium (1·12 for 15μ and 1·45 for 50μ, P<0.001). Using 15μ spheres, it was found that the ratio of endocardial to epicardial radioactivity in the left ventricular wall was increased by propranolol, decreased by isoprenaline, and unchanged by nitroglycerin. [ABSTRACT FROM PUBLISHER]

Published
1971

7. Effect of propranolol on regional myocardial blood flow in acute ischaemia1.

Author

Pitt, Bertram and Craven, Philip

Abstract

In the anaesthetized dog propranolol alters the distribution of intramyocardial blood flow, in that flow is selectively decreased to non-ischaemic areas. The failure of propranolol to reduce flow to ischaemic areas of myocardium may have several explanations which are discussed. [ABSTRACT FROM PUBLISHER]

Published
1970

14. Respiratory Failure With Focal Neurological Signs

Author

PITT, BERTRAM, ALKALAY, ISRAEL, SWEET, ROGER, and STEIN, MYRON

Abstract

PAPILLEDEMA and generalized neurologic signs have been observed frequently in patients with respiratory failure.1-6 Textbooks of neurology, however, give only brief reference to generalized neurologic abnormalities in metabolic disorders and fail to mention the occurrence of focal neurologic signs in these disorders. The present report describes three patients with focal neurologic signs who illustrate the difficulties that may occur in differentiating the neurologic consequences of early respiratory failure from space occupying lesions of the brain. REPORT OF CASES CASE 1. —A 54-year-old woman was admitted to the Beth Israel Hospital on July 2, 1961, complaining of increasingly severe frontal headaches of three months' duration. The pain radiated from the front of her head to her left occiput and shoulder and occasionally disturbed her sleep. The pain usually lasted several hours. Three weeks prior to admission she developed blurred vision, vertigo, tinnitus, paresthesiae, and weakness of the fingers of the

Published
1965
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