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Mixed ligand transition metal complexes of Cu(II), Co(III), Rh(III) and Pt(IV) ions with dibasic acids viz., diphenic acid and adipic acid as primary ligands and amine bases as secondary ligands have been synthesized. They were characterized by conventional physical and chemical analyses. The antibacterial and antifungal activities have been evaluated for the synthetic ligands. Disc diffusion methods were employed for antimicrobial assays against five pathogenic bacteria and two fungi. The complexes containing 8-hydroxy quinoline as secondary ligand were much more active than the other complexes. In addition, the complex [Rh(DA)(8-HQ)(H 2 O) 2 ] ( 4 ) showed the highest antibacterial activity against all bacteria tested (where, DA = Diphenic acid, 8-HQ = 8-hydroxyquinoline) and the complex [Pt(A) 2 (Q) 2 ] ( 3 ) showed the lowest. On the other hand, he highest inhibition of growth occurred by complex K[Cu(DA)(8-HQ)] ( 1 ) against the fungi Botryodiplodia theobromae and the lowest by complex [Rh(DA)(8-HQ)(H 2 O) 2 ] ( 4 ) against the fungi Colletotrichum gloesparioides . Key words: Biological activity, Diphenic acid, Heterocyclic amine, Mixed ligand complexes doi: 10.3329/dujps.v7i2.2170 Dhaka Univ. J. Pharm. Sci. 7 (2): 145-148, 2008 (December)

Mixed ligand transition metal complexes of Cu (II), Co (III), Rh (III) and Pt (IV) ions with dibasic acids viz., diphenic acid and adipic acid as primary ligands and amine bases as secondary ligands have been synthesized. Their conventional physical and chemical analyses have been done. The antifungal activities have been evaluated by Disc Diffusion method employed for antifungal assays against two pathogenic fungi. All the complexes show moderate antifungal activity. The highest inhibition of growth occurred on complex [Cu (DA)(8-HQ)] against the fungi Botryodiplodia theobromae and the lowest on complex [Rh (DA)(8-HQ)(H 2 O) 2 ] against the fungi Colletotrichum gloesparioides penz. Key words: Biological Activity, diphenic acid, heterocylic amine, mixed ligand complexes DOI: 10.3329/diujst.v4i1.4357 Daffodil International University Journal of Science and Technology Vol.4(1) 2009 pp.57-59