1. Detection, Occurrence, and Prophylactic Treatment of Borderline Ketosis with Propylene Glycol Feeding
- Author
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L.D. Brown, G. N. Blank, Nancy Burg, and R.S. Emery
- Subjects
education.field_of_study ,Chemistry ,Population ,food and beverages ,Ice calving ,medicine.disease ,Excretion ,Rumen ,Animal science ,medicine.anatomical_structure ,Biochemistry ,Lactation ,Genetics ,medicine ,Herd ,Ketone bodies ,Animal Science and Zoology ,Ketosis ,education ,Food Science - Abstract
Summary Milk ketones were determined by a new test at weekly intervals for 132 cows freshening in two herds in one year and for 61 cows in two herds for a second year. If the milk ketones exceeded 2 mg/100ml during the first year, alternate cows were treated daily with 12oz propylene glycol for ten days, or served as controls. The cows were controls or fed propylene glycol (4 or 8 oz/day) from the time of calving during the second year's study. Milk ketones in excess of 2 mg/100ml occurred in 49% of the population during the first 30 days postpartum. Propylene glycol lowered milk ketones an average of 0.6 mg/100ml over the entire population and increased milk production 1 lb/cow/day for the first 60 days postpartum. These over-all differences were not significant at the 5% probability level, although significant differences did occur within herds. Three cows given intraruminal doses of 2lb propylene glycol were used to demonstrate a rumen disappearance half-time of 1 hr. Subsequent blood levels ranged as high as 57 mg/100ml. Ruminal destruction of propylene glycol was small. Metabolism trials with four cows demonstrated that body retention of propylene glycol exceeded 99% even when 5.4 lb/day was fed. Excretion of propylene glycol in milk was less than 0.1% of the dose (below detection limits).
- Published
- 1964