1. An experimental study of intraoral carcinogenesis in rats
- Author
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Takeo Yamamura, Osamu Watanabe, Toru Ichikawa, Yasuhiko Nishida, Masaki Shimono, Heiichiro Koike, Michiko Yoshida, Shigeo Eda, Hachiro Matsuyama, Tetsuhiko Tachikawa, and Hitomi Yamane
- Subjects
Pathology ,medicine.medical_specialty ,Hemangiosarcoma ,DMBA ,Fibroma ,Epithelium ,Pathology and Forensic Medicine ,Benz(a)Anthracenes ,medicine ,Carcinoma ,Animals ,Oral mucosa ,General Dentistry ,Nitrosoguanidines ,Adenoma sebaceum ,Neurofibroma ,Lymphangioma ,Papilloma ,business.industry ,Carcinoma in situ ,Mouth Mucosa ,Epithelial Cells ,Neoplasms, Experimental ,medicine.disease ,Rats ,stomatognathic diseases ,medicine.anatomical_structure ,Carcinoma, Squamous Cell ,Mouth Neoplasms ,medicine.symptom ,Hemangioma ,business ,Carcinoma in Situ ,Methylcholanthrene - Abstract
A new method has been devised for preparing artificial cecal pouches lined with mucous epithelium in the lower lips of Wistar and Sprague-Dawley rats in order to make carcinogens act continuously for a long time in the oral mucosa. When a 0.5 per cent mineral oil solution of DMBA, a crystal of MC, and a crystal of NG were administered, squamous-cell carcinoma, carcinoma in situ, papilloma, adenoma sebaceum. neurofibroma, fibroma, hemangiosarcoma, hemangiosarcoma, hemangioma, and lymphangioma were successfully produced in the oral mucosa of rats. In addition, interesting findings were obtained concerning tissue changes in the process of carcinogensis in the mucous epithelium.
- Published
- 1975
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