1. Biological significance of the early structural alterations in skeletal muscle fibers infected by Trichinella spiralis
- Author
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Diego Ribas-Mujal and Jose Maria Rivera-Pomar
- Subjects
Pathology ,medicine.medical_specialty ,Myofilament ,Diaphragm ,Trichinella spiralis ,Sarcoplasm ,Golgi Apparatus ,Intercostal Muscles ,Trichinosis ,Pathology and Forensic Medicine ,Muscle hypertrophy ,symbols.namesake ,Myofibrils ,medicine ,Animals ,Molecular Biology ,Cell Nucleus ,biology ,Muscles ,Skeletal muscle ,Trichinellosis ,Cell Biology ,General Medicine ,Golgi apparatus ,Hyperplasia ,medicine.disease ,biology.organism_classification ,Mitochondria, Muscle ,Rats ,Microscopy, Electron ,medicine.anatomical_structure ,symbols ,Ribosomes ,Cell Nucleolus - Abstract
Skeletal muscle fibers of the rat were studied with the electron microscope during the first stages of Trichinella spiralis infection. Severe changes in the fine structure caused by the larvae within the muscle fiber may be summarized as follows: 1) Increase of the sarcoplasmic matrix. 2) Fragmentation and lysis of the myofilaments. 3) Hyperplasia of the RS system. 4) Hyperplasia of the T system tubules which develop peculiar multitubular and multivesicular complexes. 5) Mitochondrial hyperplasia and hypertrophy. 6) Increase in number of the Golgi complexes. 7) Enlargement of and increase in number of the nuclei.
- Published
- 1968
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