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I131-hippuran renography was performed in connection with 21 homologous kidney transplantations in man. A total of 348 renograms were obtained and have been compared with the clinical course.The post-operative renograms had a normal appearance when ischaemia lasted less than 42 minutes. Longer ischaemia times first caused the excretion phase to disappear, giving an accumulation curve. The uptake phase was considerably more resistant, being present even when ischaemia lasted more than 6 hours.The presence of an uptake phase, however small, implies that blood is reaching the renal cortex. This provides a convenient indicator of circulation in the transplant. The excretion phase of the renogram is affected by all factors, such as impaired urinary production and urinary flow.The renogram generally displays typical changes in conjunction with rejection, sometimes before other symptoms can be detected. Renograms taken at an early stage can be used to distinguish between an oliguria due to imminent rejection and...

The concept of “Self” has both an immunological and a psychological meaning. Fifteen patients, on whom a kidney has been transplanted, from related donors or from cadavers, have been interviewed with regard to their psychological recognition of the kidney as part of their “Self”. The results are presented in a table and discussed.

Summary. Subcutaneously injected Fe59Cl3 in mice accumulates to a fairly large extent in the kidneys. The first few days after injection several structures (except glomeruli) in the cortex contained much radioiron. Nine days after injection the radioiron was mainly localized in proximal convoluted tubules. The marrow contained small amounts of radioiron throughout. The mechanisms underlying the found distribution of radioactive iron are unexplained by the present experiments.

AMONG test substances used in the examination of kidney function, according to Taplin et al.1, sodium iodohippurate labelled with iodine-131 seems to have great clinical value owing to its high excretion-rate in urine and its low uptake in the liver2,3. However, it is known that some substances containing iodine have a tendency to decompose in certain physical conditions. If this would be the case with iodohippurate labelled with iodine-131 the decomposition products would differ biologically from the original substance and would disturb the evaluation of the kidney function test. In an attempt to analyse these problems I have examined the purity and stability of radioactive iodohippurate.