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A series of Mannich base derivatives of N-(2-thiazolyl)-1-phenol-4-sulfonamide has been synthesized and characterized largely in the form of hydrochloride salts and acetyl derivatives. The results on a variety of biological screening tests carried out on these compounds have been reported.

Eleven Mannich bases derived from 5‐nitro‐2‐acetylfuran and 5‐nitro‐2‐furfuralacetone have been prepared using various dialkyl and heterocyclic secondary amines. These β‐aminoketones are to be screened for possible pharmacodynamic activity.

N-Mannich bases of salicylamide, using aliphatic and heterocyclic secondary amines,have been prepared and their mode of formation and mechanism discussed.

The synthesis of a group of Mannich bases and secondary and tertiary γ-aminoalcohols derived from hexamethylenimine are described. These compounds are to be screened for possible pharmacological action.

The hydrolysis of 2-(4-phenyl-1-piperazinylmethyl)cyclohexanone hydrochloride, a Mannich condensation product, was studied in buffered aqueous solutions in the pH range of 1.1 to 5.5. The hydrolytic products, N -phenylpiperazine and a rearranged dimer of 2-methylenecyclohexanone, were isolated and characterized. The hydrolysis was specific acid and general base catalyzed with maximum stability around pH 2. The hydrolysis was pseudo first order in nature with an energy of activation, uncorrected for the heat of ionization of water, of 27.3 Kcal./mole.

Mannich Bases from 7-Hydroxy-4-methyl-6-ethyl- and 7-Hydroxy-4,6-dimethyl-coumarins as Possible Central Nervous System Stimulants.

Mannich bases from several substituted thiochromanones have been prepared with a view to testing them for their antiamoebic activity.

Mannich Bases from Ethyl 6-Hydroxy-3-methyl-coumarone-2-carboxylate.