1. Pulmonary Function in Chronic Severe Anaemia
- Author
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Jain Bp, M. M. Markose, Gupta Rg, Guleria Js, and J. N. Pande
- Subjects
Adult ,Male ,Pulmonary Circulation ,medicine.medical_specialty ,Adolescent ,Ventilation perfusion mismatch ,Ventilation/perfusion ratio ,Pulmonary function testing ,Oxygen Consumption ,Internal medicine ,Diffusing capacity ,Ventilation-Perfusion Ratio ,medicine ,Humans ,Lung ,Lung Compliance ,Anemia, Hypochromic ,Chemistry ,Pulmonary Diffusing Capacity ,General Medicine ,Carbon Dioxide ,Alveolar–arterial gradient ,medicine.disease ,Capillaries ,Surgery ,Oxygen tension ,Oxygen ,Spirometry ,Respiratory alkalosis ,Chronic Disease ,Cardiology ,Female ,Alkalosis, Respiratory - Abstract
1. The process of pulmonary ventilation and gas exchange was investigated in twenty-three young patients with chronic severe anaemia, before and after its correction. 2. Various lung volumes, pulmonary mechanics, minute ventilation, oxygen consumption and carbon dioxide production were found to be normal in anaemic patients. 3. There was a mild respiratory alkalosis in anaemia. The arterial oxygen tension was lowered because of a marked widening of the alveolar-arterial oxygen tension gradient. This was mainly because of an increase in the anatomical shunt as well as ventilation/perfusion inequalities. 4. The transfer factor (pulmonary diffusing capacity) in anaemia was very much reduced. The diffusing capacity of the alveolar capillary membrane was usually decreased and volume of blood in the alveolar capillaries usually increased but these changes were not statistically significant.
- Published
- 1971
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