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The study was conducted to determine microbial spoilage of skins of Black Bengal goats at various stages and to assess the efficacy of modified curing processes of that skins, during the period of July to November 2006. A total number of six intact skins from Black Bengal goat of two years of age were obtained from markets located at Bangladesh Agricultural University Campus and Mymensingh town. After the usual traditional method of flaying these skins were properly washed prior to curing process. Raw or green skin samples without subjected to treatment process were used as control. Two categories of samples were prepared, one immediately after the completion of flaying, i.e. considered as zero hour of sampling and the other after twenty-four hours of storage at the ambient temperature. The rest of the samples were treated with different preparations of Neem oil, Tolcide (30L), and Busan (40L) and common salt and kept for various periods. From each of the differently treated skins, bacteriological samples were taken aseptically from the regions of shoulder, belly and butt each sampling weighing about 10 grams. The bacteriological analysis of the samples was performed by determining total viable count in order to find out the extent of contamination and varying bacterial load of the three different regions. Moreover, the isolation and identification of various bacteria contaminating the skin samples was done and the efficacy of curing agents to minimize bacterial load and the survivability of microbes were studied. The results showed that Staphylococci , E. coli , Bacillus , Pseudomonas etc bacteria were isolated from raw and cured skin samples and Tolcide (30L) 0.04% and Busan (40L) 0.04% and Neem oil 10% and common salt 20% were the best curing agents from microbial quality point of view. Key words: Goats skin, curing agent, bacterial load, TVC, TCC, TSC Â doi: 10.3329/bjvm.v6i2.2335 Bangl. J. Vet. Med. (2008). 6 (2): 191-196