Search

Antiulcer effects of N-acetyl-L-glutamine aluminum complex (KW-110) were studied in experimental gastric and duodenal ulcer models in the rat, comparing its effect to that of atropine sulfate. It was found that KW-110, given orally 3 times daily for 8 days, had an accelerating activity on the healing process of duodenal ulcer whereas atropine sulfate, given s.c. twice daily for 8 days at a glutamine dose to Sufficiently suppress gastric secretion, had a significant effect. In addition, KW-110 showed remarkable effects on prevention of acutely induced experimental gastric ulcers. In regard to the Shay ulcer or aspirin-induced gastric lesions, KW-110 showed enhanced effects which exceeded the apparently maximum effects of atropine sulfate, even though the dosage of the former was much higher than that of the latter. While atropine sulfate completely inhibited the stress-induced gastric lesions, KW-110 also revealed a strong inhibition on the lesions.

The filtrate of fluid medium inoculated with Aspergillus fumigatus and cultured at 37°C for 3 weeks was dialysis with water and freeze-dried and yellowish brown powder was attained.The original dilution of the antigen, 100 mg/ml dilution of the powder, and its 2, 4, 8, 16, 32, 64 times dilution were used as the antigen and double diffusion test in agar Bell and immunoelectrophoresis were performed with the serum of patients with pulmonary aspergillosis, tuberculosis and other misceraneous diseases in internal medicine. In 14 cases of pulmonary aspergilloma, precipitin was demonstrated in 13 cases.In tuberculosis, patients with cavity had the precipitin in 5 cases of 55 cases, whereas, those without cavity in none out of 22 cases. None of the 240 cases of miscellaneous diseases had the antibody.The antibody was completely removed from the serum of aspergilloma patients to neutrophils of patients with various disease and calculating the cells fed with Aspergillus spores.The serum acceralated the rate of phagocytosis of neutrophils in the diseases. After absorption the opsonic activity was also lost.In six cases of aspergilloma, the antibody fraction belongs to IGA and IGG.It is concluded that the precipitin test is useful for the diagnosis of pulmonary aspergillosis and the prevalence of mycosis in leukemia is largely due to the lack of phagocytic activity of the leucocytes, which is acceraleted by the antibody.

Effects of crude platycodin on gastric secretion and experimental ulcerations were studied in the rat. Crude platycodin markedly inhibited gastric secretion and prevented peptic ulcers in the pylorus ligated rat but had a rather slight effect on stress induced ulceration. Curative effect of crude platycodin (25mg/kg/day) on acetic acid induced ulceration was also observed.

A standard method for the production of gastric lesions by aspirin in rats was elaborated, and the mechanisms of the deleterious effects of aspirin were interpreted. The method consisted of pylorus ligation of the rat immediately before aspirin dosing, resulting in severe and consistent gastric lesions in the glandular portion of the rat stomach 7 hr later. Sodium bicarbonate and L-glutamine showed a strong inhibitory effect on the development of aspirin-induced lesions, at almost the same dose level. Aspirin itself reduced the gastric acidity in pylorus-ligated rats. Sodium bicarbonate with or without aspirin markedly lowered the gastric acidity, whereas L-glutamine with or without aspirin restored the reduced acidity by aspirin or increased the acidity more than the normal level. These findings suggest that Lglutamine may inhibit the back diffusion of HCl into the gastric mucosa caused by aspirin. Amylopectine sulfate and sulfated glyptide, in a dose sufficient to suppress the peptic activity of gastric contents, slightly inhibited the aspirin-induced lesions. Atropine sulfate, which strongly reduced gastric juice volume but not acidity, did not exert a marked influence on aspirin-induced lesions.