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Disagreements in serum and urine cephaloglycin determinations by Sarcina lutea with those by Bacillus subtilis or Streptococcus hemolyticus after oral administration of the antibiotic have been clarified by the present studies, attention being focussed on the formation of an active metabolite, desacetylcephaloglycin. The formation of desacetylcephaloglycin was detected by paper and thin-layer chromatography. Desacetylcephaloglycin was 0.1 to 0.5 as active as cephaloglycin against B. subtilis and S. hemolyticus but of comparable activity- against S. lutea PCI-1001.

This paper is based on the results of clinical use fections showed good responses less frequently of a new chemotherapeutic agent, gentamicin, than other categories of infection, in 339 patients in Japan, compiled from the reTable 4 summarizes the results of 141 patients ports of 33 investigators. Of these 339 patients, with urinary tract infections. In this table the 179 were reported at the First International cases were classified as "simple acute" and Symposium on Gentamicin in Paris, January, "chronic complicated" infections. Of the simple 1967. acute urinary tract infections, all but 2 were sueAs shown in table 1, 162 of the patients were cessfully treated with gentamicin, but 307o of males and 177 females; they ranged in age from the cases of chronic, complicated urinary tract 22 days to 81 years. infections failed to improve. Treatment of inTable 2 shows the classification according to fections caused by Pseudomonas and Proteus was site of infection and the causative microorganisms. less successful than those due to other microor