1. [A new substituted benzamide with neuroleptic effects: lin 14 18 or sultopride]
- Author
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H, Dufour, J, Castelli, H, Luccioni, J C, Scotto, and J M, Sutter
- Subjects
Adult ,Male ,Clinical Trials as Topic ,Middle Aged ,Delusions ,Tranquilizing Agents ,Psychotic Disorders ,Benzamides ,Schizophrenia ,Drug Evaluation ,Humans ,Parkinson Disease, Secondary ,Sulpiride ,Aged - Abstract
After the research about Sulpiride, a new substituted benzamide has been studied. Although it was characterized by modest pharmacological effects in the neuroleptic identification tests, LIN 1418 turned out to have very interesting therapeutic properties. A study conducted with 50 cases, 30 of which were submitted a systematic pluridisciplinary control, leads to provisory conclusions as follows: 1) its psychotropic effects are powerful and constant; 2) its prevailing action is antipsychotic and desinhibiting altogether; 3) while LIN 1418 appears as successful with all psychoses, whether acute or chronic, up to now, the quality of its results in many chronic psychoses seems to be particularly remarkable; 4) its side-effects are those of most neuroleptics: its extrapyramidal symptoms being all the more obvious as the patient's "passivity" is less important. more...
- Published
- 1975