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Your search keyword '"Hyyppä*, M. T."' showing total 9 results
Start Over Author "Hyyppä*, M. T." Publication Year Range More than 50 years ago
9 results on '"Hyyppä*, M. T."'

3. Rapid accumulation of H3-serotonin in brains of rats receiving intraperitoneal H3-tryptophan: Effects of 5, 6-dihydroxytryptamine or female sex hormones

Author

Hyyppä, M. T., Cardinali, D. P., Baumgarten, H. G., and Wurtman, R. J.

Abstract

Summary The specific activities of brain and plasma H3-tryptophan and brain H3-serotonin increased approximately linearly for only 6 min after animals received intraperitoneal tracer doses of H3-tryptophan. The maximum rate of brain serotonin synthesis could thus be estimated from data collected during this interval, but not thereafter. Pretreatment of rats with intraventricular 5, 6-dihydroxytryptamine, a compound that damages serotoninergic neurons, decreases brain tryptophan and serotonin concentrations, accelerates the labelling of brain tryptophan by injected H3-tryptophan, and markedly decreases the rate at which H3-tryptophan accumulates as brain H3-serotonin. The treatment of oophorectomized rats with estradiol and progesterone does not appear to modify brain serotonin synthesis.

Published
1973
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6. Sex-dependent increase in pineal hydroxyindole-O-methyl transferase activity after a single intraventricular injection of 6-hydroxydopamine to newborn rats.

Author

Hyyppä MT, Cardinali DP, and Wurtman RJ

Subjects
Animals, Animals, Newborn, Castration, Female, Hydroxydopamines administration & dosage, Hypothalamus metabolism, Male, Melanins metabolism, Norepinephrine metabolism, Rats, Retina enzymology, Serotonin metabolism, Sex Factors, Testosterone pharmacology, Brain drug effects, Hydroxydopamines pharmacology, Methyltransferases metabolism, Pineal Gland enzymology, Sympathetic Nervous System drug effects
Published
1973
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7. Failure of sex steroid hormones to affect brain serotonin synthesis in rats.

Author

Hyyppä MT and Cardinali DP

Subjects
Animals, Animals, Newborn, Brain drug effects, Castration, Female, Male, Ovary physiology, Rats, Testis physiology, Tritium, Tryptophan metabolism, Brain metabolism, Estradiol pharmacology, Progesterone pharmacology, Serotonin biosynthesis, Testosterone pharmacology
Published
1973

8. Fate of intracisternally injected melatonin in the rat brain.

Author

Cardinali DP, Hyyppä MT, and Wurtman RJ

Subjects
Animals, Brain drug effects, Chromatography, Thin Layer, Darkness, Hypothalamus drug effects, Hypothalamus metabolism, Light, Male, Melatonin administration & dosage, Melatonin pharmacology, Rats, Time Factors, Tritium, Brain metabolism, Melatonin metabolism
Published
1973
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9. Time-dependent changes in brain 3 H-norepinephrine disappearance caused by L-DOPA administration.

Author

Hyyppä MT and Wurtman RJ

Subjects
Animals, Brain Chemistry drug effects, Cisterna Magna, Deamination, Dihydroxyphenylalanine administration & dosage, Dihydroxyphenylalanine analysis, Injections, Intraperitoneal, Injections, Spinal, Male, Methylation, Norepinephrine analysis, Rats, Time Factors, Tritium, Brain metabolism, Dihydroxyphenylalanine pharmacology, Norepinephrine metabolism
Published
1972
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