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Your search keyword '"Hemin pharmacology"' showing total 11 results
Start Over Descriptor "Hemin pharmacology" Publication Year Range More than 50 years ago
11 results on '"Hemin pharmacology"'

1. Liver and red-cell porphobilinogen synthase in the adult and fetal guinea pig.

Author

Weissberg JB and Voytek PE

Subjects
Aging, Animals, Chromatography, DEAE-Cellulose, Electrophoresis, Disc, Electrophoresis, Polyacrylamide Gel, Female, Gestational Age, Guinea Pigs, Hemin pharmacology, Hydrogen-Ion Concentration, Isoelectric Focusing, Kinetics, Lead pharmacology, Liver growth & development, Male, Mercury pharmacology, Pentosyltransferases blood, Porphobilinogen Synthase antagonists & inhibitors, Porphobilinogen Synthase blood, Porphobilinogen Synthase isolation & purification, Purine Nucleotides, Time Factors, Erythrocytes enzymology, Fetus enzymology, Hydro-Lyases metabolism, Liver enzymology, Porphobilinogen Synthase metabolism
Published
1974
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2. Control of delta-aminolevulinate synthetase activity in Rhodopseudomonas spheroides. III. Partial purification of the fraction I activating enzyme and the occurrence of two forms of fraction II.

Author

Hayasaka S and Tuboi S

Subjects
5-Aminolevulinate Synthetase antagonists & inhibitors, Chromatography, Gel, Chromatography, Ion Exchange, Cystine pharmacology, Darkness, Enzyme Activation, Hemin pharmacology, Hot Temperature, Kinetics, Light, Magnesium, Molecular Weight, Oxygen, Porphyrins pharmacology, Time Factors, Trypsin, 5-Aminolevulinate Synthetase metabolism, Rhodobacter sphaeroides enzymology
Published
1974
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3. Control of globin synthesis by hemin. An intermediate form of the translational repressor in rabbit reticulocyte lysates.

Author

Gross M

Subjects
Animals, Binding Sites, Carbon Radioisotopes, Cytosol metabolism, Drug Stability, Hot Temperature, Kinetics, Leucine metabolism, Protein Binding, Rabbits, Reticulocytes cytology, Reticulocytes drug effects, Subcellular Fractions metabolism, Temperature, Time Factors, Ultracentrifugation, Globins biosynthesis, Heme pharmacology, Hemin pharmacology, Protein Biosynthesis drug effects, Reticulocytes metabolism
Published
1974
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4. Differential rates of initiation of conalbumin and ovalbumin messenger ribonucleic acid in reticulocyte lysates.

Author

Palmiter RD

Subjects
Animals, Cell-Free System, Centrifugation, Density Gradient, Chickens, Ducks, Electrophoresis, Polyacrylamide Gel, Hemin pharmacology, Kinetics, Muramidase biosynthesis, Ovalbumin biosynthesis, Polyribosomes, Potassium pharmacology, Precipitin Tests, Rabbits immunology, Reticulocytes drug effects, Species Specificity, Temperature, Time Factors, Egg Proteins biosynthesis, Peptide Chain Initiation, Translational drug effects, Protein Biosynthesis drug effects, RNA, Messenger metabolism, Reticulocytes metabolism
Published
1974

5. Induction of delta-aminolevulinate synthetase in organ culture of chick embryo liver by allylisopropylacetamide and 3,5-dicarbethoxy-1,4-dihydrocollidine.

Author

Tonita Y, Oashi A, and Kikuchi G

Subjects
Animals, Binding Sites, Chick Embryo, Chromatography, Gel, Cycloheximide pharmacology, Cytosol enzymology, Dactinomycin pharmacology, Dicarboxylic Acids pharmacology, Enzyme Induction, Half-Life, Hemin pharmacology, Organ Culture Techniques, Transcription, Genetic, 5-Aminolevulinate Synthetase biosynthesis, Acetamides pharmacology, Allylisopropylacetamide pharmacology, Liver enzymology, Pyridines pharmacology
Published
1974
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6. [The significance of the bacterial steroid degradation for the etiology of large bowel cancer. II. Deoxycholic acid--the growth promoting factor of bile for saccharolytic bacteroides species (author's transl)].

Author

Edenharder R

Subjects
Anaerobiosis, Bacteroides drug effects, Bacteroides metabolism, Brain, Cholic Acids metabolism, Cholic Acids pharmacology, Culture Media, Deoxycholic Acid metabolism, Glycocholic Acid metabolism, Glycocholic Acid pharmacology, Hemin pharmacology, Humans, Species Specificity, Stimulation, Chemical, Tissue Extracts pharmacology, Bacteroides growth & development, Colonic Neoplasms etiology, Deoxycholic Acid pharmacology, Growth Substances
Published
1974

7. Hemin control of globin synthesis. Isolation of a hemin-reversible translational repressor from human mature erythrocytes.

Author

Freedman ML, Geraghty M, and Rosman J

Subjects
Animals, Carbon Radioisotopes, Cell-Free System, Chromatography, Gel, Drug Stability, Erythrocytes drug effects, Hot Temperature, Humans, Hydrogen-Ion Concentration, Kinetics, Leucine metabolism, Molecular Weight, Rabbits, Reticulocytes metabolism, Ribosomes metabolism, Temperature, Time Factors, Trypsin, Erythrocytes metabolism, Globins biosynthesis, Heme pharmacology, Hemin pharmacology, Protein Biosynthesis drug effects
Published
1974

10. Control of globin synthesis by hemin: factors influencing formation of an inhibitor of globin chain initiation in reticulocyte lysates.

Author

Gross M and Rabinovitz M

Subjects
Animals, Binding Sites, Blood Proteins pharmacology, Carbon Radioisotopes, Cell-Free System, Centrifugation, Density Gradient, Chromatography, Gel, Chromatography, Ion Exchange, Cytoplasm metabolism, Kinetics, Leucine metabolism, Molecular Weight, Polyribosomes drug effects, Polyribosomes metabolism, Protein Binding, Rabbits, Reticulocytes drug effects, Spectrophotometry, Ultraviolet, Sulfhydryl Reagents pharmacology, Time Factors, Globins biosynthesis, Heme pharmacology, Hemin pharmacology, Peptide Chain Initiation, Translational drug effects, Reticulocytes metabolism
Published
1972
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11. Effect of acriflavin on the kinetoplast of Leishmania tarentolae. Mode of action and physiological correlates of the loss of kinetoplast DNA.

Author

Simpson L

Subjects
Animals, Autoradiography, Cell Culture Techniques methods, Cell Nucleus metabolism, Centrifugation, Density Gradient, Cesium pharmacology, Chlorides pharmacology, DNA analysis, DNA biosynthesis, DNA drug effects, Electrophoresis, Erythrocytes parasitology, Hemin pharmacology, Kinetics, Microscopy, Fluorescence, Mutation, Proflavine pharmacology, Time Factors, Acriflavine pharmacology, DNA, Kinetoplast drug effects, Fluorescent Dyes pharmacology, Leishmania metabolism
Abstract

The loss of kinetoplast DNA in Leishmania tarentolae, which occurs in the presence of low concentrations of acriflavin, was found to be a result of selective inhibition of replication of this DNA. Nuclear DNA synthesis was relatively unaffected and cell and kinetoplast division proceeded normally for several generations. An approximately equal distribution of parental kinetoplast DNA between daughter kinetoplasts resulted in a decrease in the average amount of DNA per kinetoplast. The final disappearance of the stainable kinetoplast DNA occurred at a cell division in which all the remaining visible kinetoplast DNA was retained by one of the daughter cells. The selective inhibition of kinetoplast DNA synthesis was caused by a selective localization of acriflavin in the kinetoplast. The apparent intracellular localization of dye and the extent of uptake at a low dye concentration could be manipulated, respectively, by varying the hemin (or protoporphyrin IX) concentration in the medium and by adding red blood cell extract (or hemoglobin). Hemin and protoporphyrin IX were found to form a complex with acriflavin. During growth in acriflavin, cells exhibited an increasing impairment of colony-forming ability and rate of respiration. No change in the electrophoretic pattern of total cell soluble proteins was apparent. The data fit the working hypothesis that the loss of kinetoplast DNA leads to a respiratory defect which then leads to a decrease in biosynthetic reactions and eventual cell death. A possible use of the selective localization of acriflavin in the kinetoplast to photooxidize selectively the kinetoplast DNA is suggested.

Published
1968
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