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The literature reports on the subject of interunit dosage and weight variations of tablets indicate that past studies were mainly concerned with analyzing the finished product to detect gross departures from the desired quality. These studies, however, were cognizant of the several stages of manufacture before the compression step could contribute to the end tablet variability. In this investigation, the variability in several stages of tablet manufacturing (dry mixing, granulating, lubricating, and tableting) was evaluated for a particular tablet formulation. The importance of employing correct sampling procedures to obtain random samples to be used for the accurate estimation of the sources of variability and product uniformity is illustrated. The relationship that exists between tablet weights and drug concentration was determined. Since systematic sampling is commonly employed in the in-process control of tableting operations, the information that can be gained from this type of sampling procedure and random sampling is presented and discussed.

A novel and accurate procedure for measuring the horizontal and vertical centration of tablet core in compressed coated tablets is described. This method of measurement permits the determination of core dislocation along and across the axis of turntable movement. The influence of size distribution of the coating granulation on core expansion and centration was studied. Results are presented for compressed coated tablets processed under similar operating characteristics on the Manesty and Kilian machines. A statistical treatment of the data was performed to permit a more meaningful interpretation and comparison of the results within one machine as well as between machines. This method for measuring core centration permits the determination of the size distribution of granulation necessary to give optimal centration.

Compressed coated tablets were prepared on a Manesty machine from four granulations of the same formulation, each having a granule of different size as its major component. The effect of granulation size on the weight variability of tablets was determined. The coating granulation sizes which give minimum and maximum weight variability are illustrated and are shown to be reproducible. The relationship that exists between weight variation and core centration is discussed.

Presents legislative bills defeated, rejected and adopted by the United States 91st Congress. Withdrawal of American troops from Vietnam; Military spending; Research and development in the military procurement bill; Seniority; Poverty program; Urban funds; Desegregation; Campus disorders; Tax reform.

Focuses on the political, economic and social issues discussed in the sessions of the 90th U.S. Congress. U.S.-Soviet Consular treaty; Housing and urban development bill; Farm subsidy payments; Anti-poverty bill.

This article offers news briefs for the week of October 16, 1965. Particular focus is given to the foreign policy of communist China, and a critique of military tactics employed by the U.S. in the Vietnam War. The article also list congressman who voted against a resolution for the U.S. to intervene against communism in Latin America. Further article topics include recorded phone messages allegedly slandering the National Congress of Parents and Teachers.