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Analysis of lipids of the intima and media of aortas with progressive stages of atherosclerosis reveals an increase in sterol and sterol ester fractions and a decrease in phospholipids. It is proposed that these changes reveal a very low rate of lipid turn-over in this tissue. The fatty acid composition of the cholesterol esters did not change with advancing atherosclerosis.

The effects of certain dietary alterations and of injections of sesame oil and estradiol dipropionate on the composition of the humeri of normal and denervated limbs of mature rats have been determined.

1. By ultracentrifligation at 90,000 × g, a particulate fraction inhibitory to growth of transplantable lymphosarcoma, Ehrlich ascites tumor and Yoshida sarcoma has been obtained from small intestines of mice and rats. 2. Inhibitory properties of the fraction have been demonstrated by pre-inoculation exposure of tumor cell suspensions to the inhibitory material. 3. The intestinal fraction markedly suppresses oxygen consumption of tumor slices, slightly reduces the respiration of normal lymphoid tissues, and has no effect on respiration of other normal tissues tested; an initial respiratory stimulation was observed with ascites tumor, followed by marked depression. 4. The active component of the intestinal fraction appears to be an ethanol and petroleum ether-soluble lipid.