Search

Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zeitschrift Für Die Gesamte Experimentelle Medizin Einschließlich Experimentelle Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zeitschrift Für Die Gesamte Experimentelle Medizin Einschließlich Experimentelle Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to analyse the mechanism of inhibition of water diuresis in adrenal insufficiency renal surface tubulus of male albino rats (group I: controls, group II: 8 days or more after bilateral adrenalectomy) have been perfused using the free flow microperfusion technique. From the percent osmotic equilibration of a hypotonic perfusate as measured cryoscopically osmotic water permeability ( L) has been calculated. Furthermore, percent osmotic equilibration has been estimated from transtubular net water flux measured with C-inulin. With both methods which constitute a maximum estimate (cryoscopic data) and a minimum estimate (inulin data) osmotic water permeability was found to be increased after adrenalectomy in distal convolutions. Hormone substitution with either cortisone (2.5 mg/100 g b.w. 24 hours i.m.) or dexamethasone (0.05 mg/100 g b.w. 24 hours i.m.) reestablished towards normal water permeability after 3 days of treatment. The data are compatible with the concept of a direct effect of glucocorticosteroids on water permeability of distal tubule membranes. In the proximal convolution osmotic water permeability was unaffected by bilateral adrenalectomy. [ABSTRACT FROM AUTHOR]

In clearance-and micropuncture-experiments the influence of dexamethasone (50 μg/100 g b.w. and 24 hrs intramuscularly over 3 to 5 days) on renal water and electrolyte excretion has been tested in adrenalectomized rats: [ABSTRACT FROM AUTHOR]