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Your search keyword '"FRANKLIN, DEAN"' showing total 83 results
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83 results on '"FRANKLIN, DEAN"'

11. Role of the spleen in the peripheral vascular response to severe exercise in untethered dogs1.

Author

VATNER, STEPHEN F., HIGGINS, CHARLES B., MILLARD, RONALD W., and FRANKLIN, DEAN

Abstract

The effects of severe, spontaneous exercise were studied on mesenteric and renal blood flows and resistances before and after splenectomy in six unrestrained, healthy dogs instrumented with miniature pressure gauges in the aorta and ultrasonic Doppler flow probes on the mesenteric and renal arteries. Before splenectomy, exercise increased haematocrit from 40 to 49%, heart rate from 76 to 290/min, mean arterial pressure from 93 to 134 mm Hg, mesenteric (+ 57%) and renal (+ 55%) resistances, while mesenteric and renal flows remained essentially constant. After splenectomy, exercise failed to increase haematocrit and increased vascular resistances to a far greater extent in the mesenteric (+144%) and renal (+199%) beds than in the intact dog, while reducing mesenteric flow by an average of 33% and renal flow by an average of 44%. Thus, in the dog the spleen contributes to the response to exercise by increasing haematocrit sufficiently to obviate reduction and diversion of visceral flows. [ABSTRACT FROM PUBLISHER]

Published
1974

28. Pattern of differential vasoconstriction in response to acute and chronic low-output states in the conscious dog1.

Author

HIGGINS, CHARLES B., VATNER, STEPHEN F., FRANKLIN, DEAN, and BRAUNWALD, EUGENE

Abstract

The extent to which the mesenteric, renal, and iliac beds respond with vasoconstriction to the low-output state of chronic failure was studied in conscious dogs with experimental heart failure produced by tricuspid insufficiency and pulmonary stenosis. While intense vasoconstriction occurred in the mesenteric and iliac beds, the renal circulation was relatively spared. A similar pattern of response was observed in a second group of normal conscious dogs when cardiac output and arterial pressure were acutely decreased by partial occlusion of the inferior vena cava. [ABSTRACT FROM PUBLISHER]

Published
1974

37. Shock: A Semantic Enigma

Author

RUSHMER, ROBERT F., primary, VAN CITTERS, ROBERT L., additional, FRANKLIN, DEAN L., additional, Baker, Donald, additional, Schlegel, William, additional, Harding, Donald, additional, Watson, Nolan, additional, and Smith, Raymond, additional

Published
1962
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47. Blood Velocity telemetered from Untethered Animals

Author

FRANKLIN, DEAN L., WATSON, NOLAN W., and VAN CITTERS, ROBERT L.

Abstract

THE magnitude of the change in frequency of sound back-scattered in moving blood is a measure of the velocity of the blood1,2. We have used this principle to design a system for telemetry of blood flow information from the major vessels of healthy, active, totally unrestrained animals.

Published
1964
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