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Your search keyword '"Dionne VE"' showing total 2 results
Start Over Author "Dionne VE" Publication Year Range More than 50 years ago
2 results on '"Dionne VE"'

1. Conductance of channels opened by acetylcholine-like drugs in muscle end-plate.

Author

Colquhoun D, Dionne VE, Steinbach JH, and Stevens CF

Subjects
Acetylcholine pharmacology, Animals, Benzene Derivatives pharmacology, Biological Transport, Active drug effects, Caprylates pharmacology, Choline analogs & derivatives, Choline pharmacology, Dicarboxylic Acids pharmacology, In Vitro Techniques, Molecular Conformation, Phenols pharmacology, Quaternary Ammonium Compounds pharmacology, Rana pipiens, Structure-Activity Relationship, Membrane Potentials drug effects, Motor Endplate drug effects, Neuromuscular Junction drug effects, Parasympathomimetics pharmacology
Published
1975
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2. Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.

Author

Dionne VE and Stevens CF

Subjects
Acetylcholine pharmacology, Animals, Anura, Carbachol pharmacology, Electric Conductivity, Electrophysiology, Hydrolysis, In Vitro Techniques, Membrane Potentials drug effects, Motor Endplate drug effects, Motor Endplate physiology, Neuromuscular Junction drug effects, Rana pipiens, Acetylcholine physiology, Neuromuscular Junction physiology
Abstract

1. End-plate currents produced by nerve-released acetylcholine and iontophoretically applied acetylcholine and carbachol have been recorded from voltage-clamped frog cutaneous pectoris neuromuscular junctions made visible with Nomarski differential interference contrast optics. 2. The effectiveness of agonists - that is, the end-plate conductance change produced by a given dose-has been determined as a function of post-junctional membrane potential. 3. As the post-junctional membrane potential is made more negative, nerve-released acetylcholine becomes less effective whereas iontophoretically-applied agonists become more effective. 4. This voltage dependence of agonist effectiveness is mediated neither by end-plate current iontophoresis of agonist into the cleft nor through electric field effects on the esterase. 5. Influences of membrane potential on the opening and closing of end-plate channel gates can account quantitatively for the voltage-dependent effectiveness of both nerve-released and iontophoretically applied agonist.

Published
1975
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