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In a newborn twin with haemolytic anaemia an unstable fetal haemoglobin was found to be the cause. The anaemia improved spontaneously with the disappearance of the fetal haemoglobin. The new Hb F (alpha2gamma2) variant was shown to have a glycine at position 130 of the 146 residues of the gamma chain. This portion is inside the globin molecule and in all known normal globins it is occupied by a residue with a bulky hydrophobic side chain. Its replacement by glycine which has no side chain would be expected to cause instability. The human gamma-chains may either have a glycine or an alanine at position 136. Evidence is brought forward to suggest that in the abnormal chain position 136 is occupied by glycine. [ABSTRACT FROM PUBLISHER]

The article presents the matters referred to the Constitution and Bylaws Committee by action at the Annual Meeting of the American Association on Mental Deficiency in the U.S. An instruction was given by the Constitution and Bylaws Committee to make a study toward making the necessary change in the name of the Association from the American Association on Mental Retardation.