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When a company seeks to merge, it usually wants a partner whose operations will complement it in some manner, such as product line, marketing, or manufacturing capability. But a successful combination depends at least as much on compatibility of fundamental business "styles," says the author. Styles are characterized by such attitudes as the degree of risk a company is willing to take in its business, the time it is content to wait to realize a gain on its investment, and the delegation of responsibility in the organization. Unless differences in styles are explored, says the author, postmerger conflicts cancel out the expected benefits of the marriage. [ABSTRACT FROM AUTHOR]

Normal doses of co‐trimoxazole (two ampoules or two tablets twice a day) gave low cerebrospinal fluid concentrations of trimethoprim and sulphamethoxazole in neurosurgical patients. For two years, four ampoules of co‐trimoxazole twice a day, followed by four tablets twice a day, which were administered to neurosurgical patients and to patients admitted to hospital with skull fractures, produced no toxicity and this regimen has not been associated with postoperative meningitis. After the high‐dose regimen in patients with uninflamed meninges, trimethoprim concentrations in the cerebrospinal fluid ranged from 2.6 μmol/L to 12.4 μmol/L (0.75 mg/L to 3.6 mg/L), and in the serum from 9.6 μmol/L to 42.7 μmol/L (2.8 mg/L to 12.4 mg/L). However, the bacteriostatic and bactericidal activities of the spinal fluids and sera were very variable, some with high concentrations appearing to have negligible antibacterial activity in vitro.We have treated a few patients with serious infections with dosages of 12 ampoules or 12 tablets twice a day with successful results. Studies of serum folate, 5‐methyltetrahydrofolate and granulocyte dihydrofolate reductase levels showed no toxic effects from the high‐dose regimen.