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3. THYMIC TRACHEOSTENOSIS AND THYMUS DEATH, WITH REPORT OF CASES*

Author

CROTTI, ANDRÉ

Abstract

To the five cases of thymus hyperplasia which I have reported, 1 I wish to add two others. In the following discussion, I shall refer sometimes to the cases previously reported.REPORT OF CASESCase 6.—Miss B. M., aged 41, suffering from an advanced exophthalmic goiter for three years, was extremely emaciated and had a marked exophthalmos. Stellwag, Graefe and Moebius symptoms were present. Pulse-rate was 88 and extremely irregular. Many of the heart-beats were not transmitted to the radial artery. The heart was enlarged. The enlargement of the thyroid gland affected both lobes and the isthmus. The right lobe was larger than the left, was irregular in surface and very hard in consistency. The inferior pole of the right lobe extended partly behind the sternum. Intense vascular symptoms, thrill and systolic murmur were present over the thyroid gland and in both supraclavicular spaces. Percussion showed a marked dulness

Published
1913
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4. THE ROENTGEN RAY IN INTRATHORACIC GOITER AND THYMUS HYPERPLASIA

Author

CROTTI, ANDRE

Abstract

By an intrathoracic goiter, we understand a goiter that lies within the thorax. It may be totally intrathoracic, or partially so. Theoretically we should call partially intrathoracic any goiter extending below the superior opening of the thorax and lying more or less deeply in the mediastinal space. According to this a goiter whose inferior limits lie behind the incisura lowing would be called an "intrathoracic goiter." Following Kocher, however, we do not call such cases "partially intrathoracic," but "struma profunda" or "deep goiter," and reserve the term of "partially intrathoracic goiter" for goiters whose greater part lies in the mediastinal space, or to goiters with an intrathoracic prolongation large enough to cause symptoms.These intrathoracic goiters originate in the lower pole of one lobe or in the isthmus, or in an accessory thyroid gland. In the majority of cases, however, the intrathroacic goiter is developed in a preexisting goiter, localized in the isthmus or one or both lobes of the thyroid gland, which has gradually become intrathoracic.

Published
1913
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16. ChemInform Abstract: KONFORMATIVE EINFLUESSE HINSICHTLICH DER AKTIVITAET VON PHARMACA 4. MITT. CYCLISCHE ANALOGA VON 1‐P‐NITROPHENYL‐2‐ISOPROPYLAMINO‐AETHANOL, SYNTH. UND UNTERSUCHUNG DER ADRENERGISCHEN BETA‐REZEPTOR‐BLOCKIERUNGS‐AKTIVITAET VON 2‐(P‐NITROPHENYL)‐4‐ISOPROPYL‐MORPHOLIN

Author

BALSAMO, A., primary, CROTTI, P., additional, MACCHIA, B., additional, MACCHIA, F., additional, DEL TACCA, M., additional, and MAZZANTI, L., additional

Published
1973
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23. Conformational effects on the activity of drugs. 5. Pharmacological properties of 2-(p-nitrophenyl)-4-isopropylmorpholine, a cyclic analog of INPEA.

Author

Del Tacca M, Bertelli A, Mazzanti L, Stacchini B, Balsamo A, Crotti P, Macchia B, and Macchia F

Subjects
Animals, Colon drug effects, Cyclization, Electric Stimulation, Ethanolamines analogs & derivatives, Ethanolamines pharmacology, Guinea Pigs, Heart Atria drug effects, Heart Rate drug effects, In Vitro Techniques, Male, Molecular Conformation, Morpholines pharmacology, Muscle Contraction drug effects, Muscle, Smooth drug effects, Rats, Receptors, Adrenergic drug effects, Structure-Activity Relationship, Vas Deferens drug effects, Ethanolamines chemical synthesis, Morpholines chemical synthesis
Abstract

2-(p-Nitrophenyl)-4-isopropylmorphine (V), an analog of 1-(p-nitrophenyl)-2-isopropylaminoethanol (INPEA, I) in which the OCHCHN chain of I is locked in a morpholine ring, loses the beta-receptor blocking activity of I on various isolated preparations. The same ineffectiveness is observed in the O-methyl (II), N-methyl (III), and N,O-dimethyl analog (IV) of I. However, some other properties which are present in I, such as inhibitory effect on acetylcholine or on 5-HT, intrinsic alpha-sympathomimetic activity, and potentiation of catecholamines, are maintained; this demonstrates a complete dissociation of these effects from beta-receptor blockade. The interactions with the alpha-adrenoceptors and with the uptake mechanism are discussed on the basis of the structure-activity relationship between I and its analogs II-V.

Published
1975
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24. Conformation effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic beta-receptor blocking activity of 2-(p-nitrophenyl)-4-isopropylmorpholine.

Author

Balsamo A, Crotti P, Macchia B, Macchia F, Del Tacca M, and Mazzanti L

Subjects
Adrenergic beta-Antagonists pharmacology, Animals, Blood Pressure drug effects, Colon drug effects, Drug Interactions, Electric Stimulation, Epinephrine pharmacology, Ethanolamines pharmacology, Female, Heart Atria drug effects, In Vitro Techniques, Isoproterenol pharmacology, Male, Methylation, Mice, Molecular Conformation, Morpholines pharmacology, Muscle Contraction drug effects, Nitrobenzenes chemical synthesis, Nitrobenzenes pharmacology, Norepinephrine pharmacology, Phenethylamines pharmacology, Rabbits, Rats, Structure-Activity Relationship, Adrenergic beta-Antagonists chemical synthesis, Ethanolamines chemical synthesis, Morpholines chemical synthesis, Phenethylamines chemical synthesis
Published
1973
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