1. Influence of insulin injected into the lateral ventricle on pituitary growth-hormone release in the rat
- Author
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M. Felici, Daniela Cocchi, E. E. Müller, Carmela Netti, and A. Pecile
- Subjects
Pituitary growth hormone ,Blood Glucose ,medicine.medical_specialty ,Electroshock ,Chemistry ,Endocrinology, Diabetes and Metabolism ,Insulin ,medicine.medical_treatment ,Cerebral Ventricles ,Injections ,Rats ,Cold Temperature ,Endocrinology ,medicine.anatomical_structure ,Ventricle ,Internal medicine ,Growth Hormone ,Pituitary Gland ,medicine ,Animals ,Female ,Pituitary Hormone-Releasing Hormones ,Injections, Intraperitoneal - Abstract
SUMMARY Injections of insulin (0·2 or 0·01 i.u./20 μl) into the lateral ventricle of the rat brain, while not changing blood glucose levels or altering the pituitary content of growth hormone (GH), blocked the release of GH from the pituitary and the decrease of growth-hormone releasing activity (GHRF) of stalk median eminence (SME) extracts in the presence of the hypoglycaemic effect on insulin (2 i.u./kg) given intraperitoneally. Intraventricular administration of insulin also impaired the GH release elicited by cold exposure (4 °C, 1 h) but not the release induced by electric shock. The possibility that insulin injected into the brain acts on glucose-sensitive GH-regulating structures is suggested.
- Published
- 1971