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TO THE EDITOR:— We have read with interest the instructive article on the treatment of pneumonia with sulfapyridine by Dr. Harrison F. Flippin and his associates (The Journal, February 11, p. 529).The wide variation in free blood sulfapyridine observed by Flippin may be accounted for on one or more of at least three grounds: (a) variability in the time at which blood samples were taken in relation to drug dosage, (b) coincidental renal impairment of function and (c) individual variability in conjugation of the drug in the blood stream.In December 1938 certain experiments were performed in our laboratories at Cold Spring Harbor which showed clearly the extreme variability in man of conjugation of sulfapyridine, especially as it appears in the urine eighteen hours after the administration of a single 3 Gm. dose by mouth. Superficially there appeared no explanation for this result, since both subjects were normal men.