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Your search keyword '"Arecoline administration & dosage"' showing total 1 results
Start Over Descriptor "Arecoline administration & dosage" Publication Year Range More than 50 years ago

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1. Drugs affecting the cholinergic system in the intact mammalian eye. I. Evaluation of the miotic activity of acetylcholine-like drugs in the mouse eye.

Author

Maayani S, Treister G, and Sokolovsky M

Subjects
Acetylcholine analogs & derivatives, Animals, Arecoline administration & dosage, Arecoline pharmacology, Carbachol administration & dosage, Carbachol pharmacology, Guinea Pigs, Hydrogen-Ion Concentration, Oxotremorine administration & dosage, Oxotremorine pharmacology, Phencyclidine administration & dosage, Phencyclidine pharmacology, Quinuclidines administration & dosage, Quinuclidines pharmacology, Acetylcholine pharmacology, Miotics pharmacology, Pupil drug effects
Abstract

The effect of concentration and pH on the miotic activity of five acetylcholine-like drugs were studied in the intact mouse eye. The data suggests that it is mainly the nonionized form of the drug which contributes to its miotic activity. Acetylcholine-like drugs, degradable by cholinesterases, exert their miotic activity at higher concentrations than do those which are resistant to enzymatic hydrolysis. More active acetylcholine-like drugs appear to be less sensitive to concentration changes.

Published
1975

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