1. Genetic control of the immune response to a thymus independent synthetic polypeptide
- Author
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Michael Sela, Anne-Marie Schmitt-Verhulst, and Edna Mozes
- Subjects
C57BL/6 ,Immunogen ,biology ,medicine.medical_treatment ,Immunology ,biology.organism_classification ,Major histocompatibility complex ,Virology ,Molecular biology ,BALB/c ,Immune system ,Antigen ,Genetics ,medicine ,biology.protein ,Antibody ,Adjuvant - Abstract
Strain dependent differences were found in the ability of inbred mice to produce antibodies to a thymus independent synthetic polypeptide, poly (DTyr, DGlu)-polyDPro-polyDLys. These differences were detected after injecting the antigen either in complete Freund's adjuvant or in aqueous solution, and were significant already in the primary response. High- and low-responder mice produced mainly antibodies of the IgG class as deduced from their mercaptoethanol resistance and their elution in the second fraction of a Sephadex G-200 chromatography. Genetic analysis of the immune response potential to poly(DTyr,DGlu)-polyDPro-polyDLys has indicated that responsiveness to this immunogen is controlled by a dominant, quantitative gene(s) which is not linked to either the major histocompatibility complex (H-2) of the mouse or to the heavy chain locus and is not located on the X-chromosome.
- Published
- 1974
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