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13 results on '"Allelic dosage"'

1. The Effects of Allelic Dosage and Graft Size on Skin Graft Survival across a Weak Histocompatibility Barrier.

Author

Lapp, W. S. and Bliss, J. Q.

Subjects
*GRAFT versus host reaction, *SKIN grafting, *ALLELES, *ANTIGENS, *CHROMOSOMES, *IMMUNITY, *IMMUNOLOGY
Abstract

Normal skin was grafted between congenic strains of mice to test the effect of allelic dosage at the weak H-1 locus. Heterozygous grafts survived longer than homozygous grafts when placed on different A hosts. The same difference was noted when both grafts were put on opposite sides of the same A host. Both allelic types gave a direct relationship between graft size and survival time over a wide size range, but the slope of the heterozygous dose-response curve was much steeper, with some of the large grafts surviving permanently. Grafts in the combination male to male survived longer than those in the combination female to female. The results are discussed in terms of a possible distinction between antigen available for the afferent and efferent immunological pathways. [ABSTRACT FROM AUTHOR]

Published
1967

2. SIGNIFICANCE OF ALLELIC DOSAGE AND GRAFT SIZE ON TOLERANCE INDUCTION BY H-1-INCOMPATIBLE SKIN GRAFTS

Author

Lapp, W S and Bliss, J Q

Abstract

A study has been carried out to determine the reason for the permanent survival of large skin grafts exchanged between animals differing at the H-1locus. Grafts that carried only a single gene difference (heterozygous) often showed permanent survival, whereas grafts having double the allelic dosage (homozygous) did not. The results indicate that the difference in skin graft survival times for the two allelic types is not attributable to a change in antigenic specificity when the allelic dosage is doubled, to surgical stress and postoperative trauma, or to graft adaptation, but, rather, to the induction of immunological tolerance by the large heterozygous skin grafts. It is suggested that the results demonstrate that, by simply manipulating the allelic dosage, the tolerogenic and immunogenic properties of the same antigenic specificity are greatly altered in the skin graft. These results are used as a model to provide a somewhat different interpretation of the concept of antigen strength for histocompatibility antigens.

Published
1970

3. THE EFFECT OF ALLELIC DOSAGE ON NEURONAL SURVIVAL IN HOMOGRAFTS OF GANGLIA IN Ag-B-HISTOINCOMPATIBLE RATS

Author

Zalewski, Andrew A.

Abstract

Neurons in homografts of ganglia of rats homozygously histocompatible at the Ag-B locus (Fischer Lewis) survive, whereas those in ganglia of homozygous Ag-B-histoincompatible rats (Brown Norway Lewis) are rejected. Since heterozygously histoincompatible H-2 homo grafts of skin in mice survive longer than homozygous ones, it seemed appropriate to study the effect of heterozygous Ag-B histoincompatibility on neuronal survival. The vagal nodose sensory or the superior cervical sympathetic ganglia were transplanted from Lewis (LE), Brown Norway (BN), or (LE X BN)F, hybrid rats to the anterior chamber of the eyes of LE hosts and examined 40 days later. In addition, BN sensory ganglia were transplanted into the sternomastoid muscles of LE hosts. All LE sensory and sympathetic auto grafts contained neurons, and no cellular immune reaction was observed. Neurons were also present in 7 of 8 sensory and 5 of 6 sympathetic Ft hybrid homografts, but all these grafts were infiltrated with lymphocytic cells. BN homografts, whether in the eye or in the muscle, lacked neurons and wore infiltrated by lymphocytic cells. The present results demonstrate an allelic dosage effect of Ag-B histoincompatibility on neuronal survival in homografts of sensory and sympathetic ganglia.

Published
1972

4. SIGNIFICANCE OF ALLELIC DOSAGE AND GRAFT SIZE ON TOLERANCE INDUCTION BY H-1- INCOMPATIBLE SKIN GRAFTS

Author

W S Lapp and J Q Bliss

Subjects
Heterozygote, Pathology, medicine.medical_specialty, Time Factors, Biology, Serology, Mice, Graft size, Stress, Physiological, Antigens, Heterophile, Immune Tolerance, Immunogenetics, medicine, Animals, Transplantation, Homologous, Antigens, Allele, Alleles, Transplantation, Homozygote, Skin Transplantation, Tolerance induction, Histocompatibility, Immunology, Spleen
Published
1970

5. The effects of allelic dosage and graft size on skin graft survival across a weak histocompatibility barrier

Author

W S, Lapp and J Q, Bliss

Subjects
Male, Mice, surgical procedures, operative, Genes, Transplantation Immunology, Genetics, Animals, Transplantation, Homologous, Female, Skin Transplantation, Articles
Abstract

Normal skin was grafted between congenic strains of mice to test the effect of allelic dosage at the weak H-1 locus. Heterozygous grafts survived longer than homozygous grafts when placed on different A hosts. The same difference was noted when both grafts were put on opposite sides of the same A host. Both allelic types gave a direct relationship between graft size and survival time over a wide size range, but the slope of the heterozygous dose—response curve was much steeper, with some of the large grafts surviving permanently. Grafts in the combination male to male survived longer than those in the combination female to female.

Published
1967

8. Hauttransplantationen zum Studium der chemischen Carcinogenese an der Mäusehaut.

Author

Worst, P., Bauz, R., Wahn, U., and Knauer, E.

Abstract

Copyright of Zeitschrift Für Krebsforschung Und Klinische Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1973
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9. Effect of Mouse Submandibular Gland Extracts on Survival of H-2 Incompatible Skin Allografts.

Author

Kongshavn, Patricia A. L. and Bliss, J. Q.

Subjects
SUBMANDIBULAR gland, HOMOGRAFTS, SERUM, LYMPHOID tissue, MICE, SKIN
Abstract

Crude saline extracts of male mouse submandibular glands prolonged graft survival time in CBA and Strong A strains of mice, both when used alone and when used in conjunction with antithymocytic serum. It is suggested that this effect is produced by a lymphoid tissue inhibitory substance found in male mouse submandibular glands. [ABSTRACT FROM AUTHOR]

Published
1970

10. Subject Index.

Subjects
INDEXES, PERIODICALS
Abstract

Presents a subject index published in the June 1967 issue of "Immunology."

Published
1967

12. Author Index.

Subjects
INDEXES, AUTHORS
Abstract

Presents a list of authors published in the June 1967 issue of "Immunology."

Published
1967

13. Polymorphism of albumin-like proteins in the South American tetraploid frog Odontophrynus americanus (Salientia: ceratophrydidae)

Author

Arno R. Schwantes, Willy Beçak, and Maria Luiza B. Schwantes

Subjects
Genetics, Male, Heterozygote, Polymorphism, Genetic, biology, Homozygote, Locus (genetics), Heterozygote advantage, General Medicine, Blood Proteins, biology.organism_classification, Blood Protein Electrophoresis, Phenotype, Starch gel electrophoresis, Salientia, Animals, Animal Science and Zoology, Female, Ploidy, Allele, Anura, Odontophrynus americanus, Alleles, Serum Albumin
Abstract

Utilizing starch gel electrophoresis, a study was made on the albuminlike plasma protein of a tetraploid South American species of frog. No allelic polymorphism at this locus was indicated in the congeneric diploid species O. cultripes, but five distinct electrophoretic phenotypes were encountered among 141 frogs of the tetraploid species O. americanus. These included two homozygous types each with a single distinctive albumin-like band, and three heterozygous types. The three heterozygotes differed from each other by relative staining intensity of the bands, and presumably represent 3:1, 2:2, and 1:3 ratios of allelic dosage. The frequency distribution of the five phenotypes among 141 frogs fitted well with the expected values calculated on the basis of the binomial (p + q)4 with allelic frequencies of 0.415 and 0.585.

Published
1968

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