1. A Possible Factor in the Etiology of Human Male Infertility: Preliminary Report
- Author
-
John MacLeod
- Subjects
Male ,Infertility ,medicine.medical_specialty ,education.field_of_study ,Genitourinary system ,Population ,Obstetrics and Gynecology ,Semen ,Biology ,Lipid Metabolism ,medicine.disease ,Sperm ,Male infertility ,Abnormal sperm morphology ,Endocrinology ,Reproductive Medicine ,Internal medicine ,medicine ,Humans ,Steroids ,education ,Infertility, Male ,Hormone - Abstract
NN1-bis(dichloroacetyl)18-octanediamine Cl2CHCONH(CH2)8NHCOCHCl2 was tested. Cytologically the semen of some infertile males show low sperm count poor motility abnormal sperm morphology with a high percentage of tapering forms and the presence of many immature cells of the germinal line. Since this seminal picture can be produced experimentally by the antispermatogenic compounds tested in these experiments and may be induced temporarily by illness the author reasons that the apparently spontaneous appearance of the combination of exfoliated cells and tapering form in individuals lacking overt clinical symptoms may be due to a disturbance in hormone distribution or to an abnormal metabolite. Evidence was sought of excessive or abnormal steroid excretion in 6 individuals presenting the required seminal picture. The data though scant point in the expected direction.
- Published
- 1962