One hundred and two patients encountered in gastroenterologic practice were given combined oxyphencyclimine-hydroxyzine tablets for an average period of 8 weeks, as part of a total regimen which included special diet and, in some cases, antacids and/or other medication. Functional bowel distress, peptic ulcer, and ulcerative colitis were the most frequent complaints, but a wide variety of other gastroenterologic disorders were treated. Most patients received ½ Enarax tablet q.i.d.; others were stabilized at ½ Enarax tablet b.i.d. Results with combined oxyphencyclimine-hydroxyzine were excellent to good in 70 patients (69 per cent); good to fair in 18 (18 per cent); and fair to poor in 14 (13 per cent). Over all excellent to fair results in controlling symptoms were attained in 88 of the 102 patients or 86 per cent of the cases studied. Dryness of mouth was frequently encountered, but tended to be relieved with adjusted dosage and continued medication. It is believed that combined oxyphencyclimine-hydroxyzine is a very useful addition to the gastroenterologist's armamentarium. Its use need not be limited to the patient with peptic ulcer and allied disorders but may be extended to therapy of functional bowel disorders and to conditions involving spasm of the sphincter of Oddi. The clinical effectiveness of Enarax may be ascribed to the properties of its components. Hydroxyzine is an antihistaminic ataractic possessing antispasmodic and antisecretory properties. The effect of oxyphencyclimine is to curb hypersecretion, spasm, and hypermotility. [ABSTRACT FROM AUTHOR]