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Various therapeutic measures and drugs have been used in minimizing the deleterious effects of cold injury. Considering the cold injury as an aseptic inflammatory process,1 we decided to evaluate the possible role of the anti inflammatory agent, oxyphenbutazone (Tanderil), in the treatment of cold injury in rabbits.

Postoperative peritoneal adhesions are one of the important causes of intestinal obstruction. Coletti and Bossart 1 reported that in their series, intestinal adhesions were responsible for 90% of small bowel obstructions in the early postoperative period. Numerous agents have been studied experimentally and clinically with regard to their usefulness in preventing the formation of intraperitoneal adhesions, but none, as yet, has proved consistently useful. Considering formation of peritoneal adhesions as an inflammatory process, 2 an anti-inflammatory agent, oxyphenbutazone, has been used in this study to prevent it. Materials and Methods Forty rabbits were anesthetized with intravenously administered pentobarbital sodium. A laparotomy was carried out by a midline incision. The cecum and corresponding parietal peritoneum were scraped until the normal gloss was lost. The abdomen was closed in layers. The animals were studied in the following groups: Group A. —This group was subdivided into two. Group Al, the control group, consisted

Peritoneal adhesions were produced in 20 rabbits and 35 monkeys by traumatizing the cecum and corresponding parietal peritoneum. Adhesions were classified into six grades, depending on the extent and density. Combined therapy with oxyphenbutazone, proteolytic enzymes from carica papaya, and dextran 40 after lysis of adhesions reduced the reformation of peritoneal adhesions significantly, and the percentage reduction was greatest as compared to the individual use of the drugs. It is emphasized that the role of any therapy in peritoneal adhesions should be evaluated only by the decrease in the reformation of adhesions after lysis.