1. MYOGLOBINURIA FOLLOWING ANAESTHESIA INCLUDING SUXAMETHONIUM
- Author
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H. Olesen, K. Jensen, K.-Aa. Bennike, and H.K. Hanel
- Subjects
Adult ,Anesthesia, Endotracheal ,Electrophoresis ,Male ,Paper ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Succinylcholine ,L-Lactate dehydrogenase ,Hemoglobins ,Humans ,Medicine ,Aspartate Aminotransferases ,Creatine Kinase ,Immunoelectrophoresis ,Aged ,Laboratory methods ,L-Lactate Dehydrogenase ,biology ,business.industry ,Myoglobinuria ,Significant difference ,Alanine Transaminase ,Middle Aged ,medicine.disease ,Surgery ,Anesthesiology and Pain Medicine ,Minor surgery ,Spectrophotometry ,Anesthesia ,Chromatography, Gel ,biology.protein ,Female ,Creatine kinase ,business ,Rhabdomyolysis ,Creatine kinase activity - Abstract
SUMMARY A 15-year-old girl developed rhabdomyolysis with myoglobinuria after anaesthesia during which suxamethonium 250 mg was injected in divided doses. The laboratory methods used for demonstration of myoglobinuria are described. The study was extended to 63 patients submitted to minor surgery. Myoglobinuria could not be demonstrated in any of these cases whether or not anaesthesia included suxamethonium as a single dose of 1 mg/kg. Creatine kinase activity measurement in 25 of these patients disclosed no significant difference between pre- and postoperative values. It is concluded that myoglobinuria in the patient presented was due to an excessive dose of suxamethonium.
- Published
- 1968
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