This article examines the consequences of urban migration for suicide by analyzing the case histories of persons who committed suicide in New Orleans. The major independent variables under consideration are migration, sex, and race. Migration confronts the individual with a new milieu that may contrast sharply with the way of life in a small town. The South provides an exceptionally pointed region for such investigation because there the urban-rural contrast is generally greater than in the older urbanized regions of the country. The urban situation is different in all of the systems that comprise human social life. In the social realm, the in-migrant lacks the family and friends of his town of orientation. The urban and rural situations are, of course, not totally different even in the South, but they are dissimilar enough to be reflected by higher deviance rates reported in the migration studies reviewed. Moving to the factor of migration, several studies demonstrate the sometimes troubling impact of city ward movement. These studies reveal that deviance is associated with non-nativity, and with the more general factor of horizontal mobility.