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This paper describes eight patients with enteropathogenic Escherichia coli treated with oral gentamycin. The antibiotic was administered in oral suspension at a dose of 25 mg./Kg./day in two divided doses for eight days. All patients were supported with intravenous fluid therapy until their physiologic disturbances were corrected. The data show a marked reduction in stool number and bulk in every patient within 36 hours after oral gentamycin sulfate was begun. Stool cultures were obtained for the first 14 days after beginning therapy and in all instances stool cultures remained positive for several days. On the other hand, the disadvantages of treating diarrheal disease of infants with antibiotics are the following: the possible emergence of resistant strains and the possible side effects of therapy.

Discusses the fibrinolytic treatment of thromboembolic disease. Potential of fibrinolysin, a fibrinolytic agent to dissolve thrombi within the circulation; Capacity to dissolve the fibrin binding the clot without affecting the other proteins in the blood producing adverse reactions; Influence of the agent in increasing the incidence of side effects.

Perhexiline Maleate was studied in 64 patients of intractable stable angina by a ‘modified double blind double cross over technique’. In the open trial the response was excellent in 26 and good in 22. After placebo, angina reappeared in 19 out of 26 with excellent response and increased in frequency and severity in 14 out of 22 with good response. A double blind double cross over study was carried out in these patients. In double blind study with Perhexiline 16 patients showed excellent, 15 good, 1 fair and 1 poor response. With placebo the response was: 1 excellent, 2 good, 7 fair and 23 poor. Use of this new approach for evaluation of anti-anginal drugs in patients suffering from intractable stable angina shows the true therapeutic potential of Perhexiline Maleate. However, the side-effects must be closely watched. It must also be realised that all patients do not respond to this drug. [ABSTRACT FROM AUTHOR]

The findings of a study of the consumption of mood-modifying prescription drugs in a large Canadian city are presented and compared with data from the United States. The consistently higher prevalence of use of these drugs by women is examined. An explanatory model is proposed, suggesting that women are permitted greater freedom than men to express feelings. perceive their feelings more readily, and hence recognize emotional difficulties. This recognition enables the woman to define her difficulties within a medical model and thus bring them to the attention of her physician. The physician, representing the society that sanctions this freer expression, expects female patients to behave in this way, and thus expects them to require a higher proportion of mood-altering drugs than the less expressive male patients. [ABSTRACT FROM AUTHOR]

Investigates the pros and cons of cromolyn sodium prophylaxis in chronically asthmatic children. Comparison of the clinical course of the patients; Side-effects of the drug; Concomitant use of bronchodilators and corticosteroids; Response of the different types of chronic asthma to cromolyn sodium.

In an open, crossover study of six months' duration, clonidine given alone and with chlorthalidone was compared in 37 patients completing the study. Significant blood pressure lowering was achieved following both clonidine and clonidine with chlorthalidone. The response was highly significant following the combination. While there was a systolic orthostatic effect, tolerance developed only after clonidine alone in this study. Adverse effects were frequently reported. They were an annoying feature of the drug, but no major toxic effects were seen, and the only significant laboratory abnormalities were those associated with diuretic therapy. Bradycardia was a common finding. Based on the findings of this study, clonidine is a valuable additional tool for the management of hypertensive vascular disease. The combination with chlorthalidone provides a much more predictable means of controlling blood pressure than clonidine alone. [ABSTRACT FROM AUTHOR]

The article focuses on allergic reactions associated with use of dextran in the treatment of thrombophlebitis and arterial insufficiency. Although dextran, a polysaccharide product of the fermentation of sucrose by the organism Leuconostoc mesenteroides, has long been known to be allergenic in humans, the incidence of adverse reactions has been very low. In a study, the authors treated 40 patients with either thrombophlebitis or inoperable peripheral arterial insufficiency with dextran.

Evaluates the treatment asthmatic children with disodium cromoglycate. Doses of inhaled drugs; Observation of dry mouth as side effects; Report of reduced school absences following therapy; Citation of the potential danger of severe exacerbation of asthma and failure of adrenocortical response if steroid doses are reduced too quickly and drastically.

The article focuses on a study which assessed parents' response to and efficacy of pediatric forms of erythromycin. The study selected patients from the Out-Patient Department of the Saint Louis Children's Hospital. Results revealed a satisfactory clinical response to erythromycin. Side effects were reported for some children which include vomiting, pruritus and sneezing with irritated eyes. Mothers' reactions are varied. Some are moved to endorsements and others responded to television advertisements.

Presents abstracts of articles concerning hypersensitivity to penicillin. "Screening Tests for the Detection of Penicillin Hypersensitivity," by John C. Trinca; "Hypersensitivity to Penicillin: A Short Review," by Alex Johnson; "Method for Detection of Penicillin Hypersensitivity," by Harold Lecks and Lillian P. Kravis.

Keloids by spectral approach have been defined and a new concept as to the course of this disease promulgated. This hypothesis explains why, on occasion, many varieties of medication seem to work. How keloids may be prognosticated in: (1) people who never had the disease, (2) the effectiveness of therapy, and (3) the proper time to do surgery, if necessary, have been suggested by newly applied biochemical tests. The safety of glucocorticoids has been dealt with over a sever year follow up wherein no patient ever had the medication stopped because of side effects. The efficiency of this medical approach, or in combination with surgery to prevent recurrence, has been demonstrated from the experiences in over 125 cases, wherein no case failure of treatment has occurred. Reasons for failure reported in the literature have been mentioned. A preliminary report in a census of 14,500 school children for keloids in Aruba, Netherlands Antilles, with ethnological and percentile breakdown has been presented. The modalities of therapy in keloids have been discussed in detail. [ABSTRACT FROM AUTHOR]

Hypertension in 52 patients was treated for 4 to 56 days with divided doses of 6 or 12 mg of trichlormethiazide and 0.3 mg of reserpine daily in combination tablets. Blood pressure in all patients was lowered; the mean average was 33/16 mm Hg. Most patients also lost weight; the mean average was 4.2 pounds. Laboratory studies indicated that the drugs did not significantly change pretreatment values for serum electrolytes, serum carbon dioxide, nonprotein nitrogen, urinary sugar or albumin, or blood chemistry. There were no clinical side effects attributable to the drugs except a pruritic rash in an elderly male patient. The results of the clinical and laboratory studies did not differ between patients treated for long or short periods of time or between patients who received 6 or 12 mg of trichlormethiazide daily. It is concluded that the combination of trichlormethiazide and reserpine provides safe and effective management of hypertension. [ABSTRACT FROM AUTHOR]

Sixty-two hypertensive patients have been treated with a new oral antihypertensive-saluretic preparation designated as Rautrax. The blood pressure response is reported for all of the patients after 1 month, for 53 after 3 months and for 37 after 6 months of therapy. Dosage was 1 tablet of Rautrax twice daily, each tablet containing 50 mg of whole root Rauwolfia serpentina, 400 mg of a new oral saluretic agent, flumethiazide, and 400 mg of potassium chloride. Normal blood pressure readings were recorded for 30 of the 62 patients after 1 month, for 29 of the 53 after 3 months, and for 18 of the 37 patients after treatment for 6 months. Significant reductions in the blood pressure levels over pretreatment values were observed in 69 per cent, 83 per cent and 89 per cent of patients after 1, 3 or 6 months of therapy, respectively. Associated symptoms such as headache, dizziness and blurring of vision were completely relieved or greatly improved in the majority of the patients. Medication was withdrawn in two patients who developed purpura, lethargy and severe diarrhea. Other side effects included transient nasal stuffiness, itchiness, increased bowel motility, occasional weakness, epigastric discomfort and a feeling of ‘shockiness’ in two diabetic patients, but these were never sufficiently severe to require discontinuance of the drug. Patients on digitalis therapy who received Rautrax gave no signs of digitalis intoxication. There were no signs of potassium loss in any patient, though none were anticipated because Rautrax contains added potassium to combat excessive loss. After periods of administration lasting for 6 months, there was no sign of tolerance to the antihypertensive action of Rautrax. Potentiation of the antihypertensive effect of rauwolfia by the concomitant administration of a diuretic-saluretic agent has been confirmed. On the basis of the findings in this study, the clinical impression was gained that Rautrax represents a valuable addition to the resources available to the physician for the medical management of hypertensive vascular disease. The combination of hypotensive-saluretic action in a single preparation provides a convenient dosage form in the treatment of the ambulatory patient. [ABSTRACT FROM AUTHOR]

Examines the cardiovascular effect of sympathicolytic drugs in individuals with hypertension. Reason behind the unsuitability of tetraethylammonium as a treatment in hypertension; Frequency of complications and side-effects from the administration of Priscol; Factors influencing the manifestation of sympathomimetic action of Benzodioxane.

Norethynodrel and mestranol in a ratio identical to that used for contraception were injected subcutaneously daily for five weeks into young adult female rats. These rats were fed with a purified caries test diet. The various lesions of the treated rats increased proportionately with increased doses of the agents. [ABSTRACT FROM AUTHOR]

This article reports on the production of edema as a side-effect of local anesthetics. The article discusses research on the cytotoxicity of these anesthetics when applied to rats to evaluate how edema is affected by prophylactic antihistamine therapy. Information is also provided on the anesthetic solutions of lidocaine, mepivacaine, and procaine.

The article discusses a study on the use and effectiveness of levo-arterenol as a vasoconstrictor. The study focused on potential side effects of Arterenol when used as a local anesthetic. Results of the study showed that although it is a more effective anesthetic than epinephrine, it also has a higher rate of side effects.