(1960). The Paper Disc Method for Determination of Bacterial Sensitivity to Antibiotics Studies on the Accuracy of the Technique. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 12, No. 4, pp. 408-413.
Six healthy men were given a fruit- and vegetable-free diet, and one man was given a pure sucrose-water diet and antibiotics for 4 days. Vanylglycol in urine was detected by paper chromatography and thin-layer chroma tography after enzymatic hydrolysis with glusulase (glucuronidase + arylsul fatase). Acid hydrolysis destroyed vanylglycol. Treatment with antibiotics and a sucrose diet did not change the vanylglycol excretion, while the mono amineoxidase inhibitor, alphamethyldopa, and reserpine decreased the excre tion. Disulfiram treatment increased the vanylglycol excretion.
medicine.medical_specialty, business.industry, medicine.drug_class, Antibiotics, Disease Management, 030209 endocrinology & metabolism, Bacterial Infections, General Medicine, 030204 cardiovascular system & hematology, Skin Diseases, Dermatology, Anti-Bacterial Agents, Surgery, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Dermatologic Agents, business
Abstract
The antibiotics have revolutionized the treatment of cutaneous bacterial infections although they have not replaced all other methods of treatment. The antibacterial spectrum and disadvantages of each antibiotic are summarized in this paper. In addition, diagnosis, predisposing factors, prognosis and therapeutic agents for the management of cutaneous pyogenic infections are discussed.
Published
1952
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