1. PROGRAM.
- Subjects
- *
CONFERENCES & conventions , *PROTEINASES , *PROTEOLYTIC enzymes - Abstract
The article provides information about the research papers that will be presented at the spring meeting of The Society for Investigative Dermatology Inc. that will be held on April 27-28, 1973 in Atlantic City, New Jersey. Cathepsin D (CD), one of the major lysosomal proteinases, has been identified in rabbit skin. Extracts of skin were capable of degrading hemoglobin, at pH 3.2, to peptides that are soluble in trichioracetic acid. This activity was blocked by the CD inhibitor pepstatin and was eluted from a Sephadex G-100 column at a position identical to that of ultimately pure rabbit liver CD. A line of complete identity between crude skin extracts and ultimately pure CD was found in immunodiffusion studies using sheep anti-rabbit CD.
- Published
- 1973
- Full Text
- View/download PDF