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1. Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study

Author

Werkman, Nikki C. C., García-Sáez, Gema, Nielen, Johannes T. H., Tapia-Galisteo, Jose, Somolinos-Simón, Francisco J., Hernando, Maria E., Wang, Junfeng, Jiu, Li, Goettsch, Wim G., van der Kallen, Carla J. H., Koster, Annemarie, Schalkwijk, Casper G., de Vries, Hein, de Vries, Nanne K., Eussen, Simone J. P. M., Driessen, Johanna H. M., and Stehouwer, Coen D. A.

Published
2024
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2. (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study

Author

Mokhtar, Sara B. A., van der Heide, Frank C. T., Oyaert, Karel A. M., van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Scarpa, Fabio, Colonna, Alessia, de Galan, Bastiaan E., van Greevenbroek, Marleen M. J., Dagnelie, Pieter C., Schalkwijk, Casper G., Nuijts, Rudy M. M. A., Schaper, Nicolaas C., Kroon, Abraham A., Schram, Miranda T., Webers, Carroll A. B., and Stehouwer, Coen D. A.

Published
2023
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3. The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Author

T Schram, Miranda, Dagnelie, Pieter C., van Greevenbroek, Marleen MJ., Stehouwer, Coen DA., van der Kallen, Carla J., Meijer, Paul, Lam, Thao Minh, Vaartjes, Ilonca, Moll van Charante, Eric, Galenkamp, Henrike, Koster, Annemarie, van den Hurk, Katja, den Braver, Nicole R., Blom, Marieke T., de Jong, Trynke, Grobbee, Diederick E., Beulens, Joline WJ., and Lakerveld, Jeroen

Published
2024
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5. Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Author

van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., and Stehouwer, Coen D. A.

Published
2023
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6. Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van Greevenbroek, Marleen M. J., Kusters, Yvo H. A. M., Vos, Rimke C., Bots, Michiel L., Kooi, M. Eline, Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Brouwers, Martijn C. G., van der Sangen, Niels M. R., Peters, Sanne A. E., van der Kallen, Carla J. H., and Stehouwer, Coen D. A.

Published
2023
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7. Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study

Author

Vandercappellen, Evelien J., Koster, Annemarie, Savelberg, Hans H. C. M., Eussen, Simone J. P. M., Dagnelie, Pieter C., Schaper, Nicolaas C., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Kroon, Abraham A., Henry, Ronald M. A., and Stehouwer, Coen D. A.

Published
2022
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8. (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study

Author

van der Heide, Frank C. T., Foreman, Yuri D., Franken, Iris W. M., Henry, Ronald M. A., Kroon, Abraham A., Dagnelie, Pieter C., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Schaper, Nicolaas C., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2022
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9. Health burden in type 2 diabetes and prediabetes in The Maastricht Study

Author

Veugen, Marja G. J., Onete, Veronica G., Henry, Ronald M. A., Brunner-La Rocca, Hans-Peter, Koster, Annemarie, Dagnelie, Pieter C., Schaper, Nicolaas C., Sep, Simone J. S., van der Kallen, Carla J. H., van Boxtel, Martin P. J., Reesink, Koen D., Schouten, Johannes S., Savelberg, Hans H. C. M., Köhler, Sebastian, Verhey, Frans R., van den Bergh, Joop P. W., Schram, Miranda T., and Stehouwer, Coen D. A.

Published
2022
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10. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Subjects
AIR pollutants, TYPE 2 diabetes, PARTICULATE matter, FRACTAL dimensions, AIR pollution
Abstract

Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy. Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM2.5, PM10, NO2, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension). Results: After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM2.5 and PM10 were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM2.5 -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM10 -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO2 and EC and corneal nerve measures. Conclusions: Our population-based study demonstrated that exposure to higher levels of PM2.5 and PM10 are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data.

Author

van Hilten, Arno, van Rooij, Jeroen, Heijmans, Bastiaan T., 't Hoen, Peter A. C., Meurs, Joyce van, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, and Beekman, Marian

Subjects
GENE expression, MULTIOMICS, PREDICTION models, NETWORK performance, INDIVIDUALIZED medicine
Abstract

Integrating multi-omics data into predictive models has the potential to enhance accuracy, which is essential for precision medicine. In this study, we developed interpretable predictive models for multi-omics data by employing neural networks informed by prior biological knowledge, referred to as visible networks. These neural networks offer insights into the decision-making process and can unveil novel perspectives on the underlying biological mechanisms associated with traits and complex diseases. We tested the performance, interpretability and generalizability for inferring smoking status, subject age and LDL levels using genome-wide RNA expression and CpG methylation data from the blood of the BIOS consortium (four population cohorts, Ntotal = 2940). In a cohort-wise cross-validation setting, the consistency of the diagnostic performance and interpretation was assessed. Performance was consistently high for predicting smoking status with an overall mean AUC of 0.95 (95% CI: 0.90–1.00) and interpretation revealed the involvement of well-replicated genes such as AHRR, GPR15 and LRRN3. LDL-level predictions were only generalized in a single cohort with an R2 of 0.07 (95% CI: 0.05–0.08). Age was inferred with a mean error of 5.16 (95% CI: 3.97–6.35) years with the genes COL11A2, AFAP1, OTUD7A, PTPRN2, ADARB2 and CD34 consistently predictive. For both regression tasks, we found that using multi-omics networks improved performance, stability and generalizability compared to interpretable single omic networks. We believe that visible neural networks have great potential for multi-omics analysis; they combine multi-omic data elegantly, are interpretable, and generalize well to data from different cohorts. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study

Author

Bakker, Lieke, Ramakers, Inez H. G. B., van Boxtel, Martin P. J., Schram, Miranda T., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Greevenbroek, Marleen M. J., Wesselius, Anke, Midttun, Øivind, Ueland, Per M., Verhey, Frans R. J., Eussen, Simone J. P. M., and Köhler, Sebastian

Published
2021
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13. Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study

Author

van Gennip, April C. E., primary, Gupta, Monideepa D., additional, Houben, Alfons J. H. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J. H., additional, Koster, Annemarie, additional, Wesselius, Anke, additional, Eussen, Simone J. P. M., additional, Schalkwijk, Casper G., additional, de Galan, Bastiaan E., additional, Köhler, Sebastian, additional, Schram, Miranda T., additional, Stehouwer, Coen D. A., additional, and van Sloten, Thomas T., additional

Published
2024
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14. Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study

Author

Foreman, Yuri D., van Doorn, William P. T. M., Schaper, Nicolaas C., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Henry, Ronald M. A., Koster, Annemarie, Eussen, Simone J. P. M., Wesselius, Anke, Reesink, Koen D., Schram, Miranda T., Dagnelie, Pieter C., Kroon, Abraham A., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2021
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15. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study

Author

Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, van Sloten, Thomas T, Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, and van Sloten, Thomas T

Published
2024

16. Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study

Author

Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmaceutical Policy and Regulation, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Werkman, Nikki C C, García-Sáez, Gema, Nielen, Johannes T H, Tapia-Galisteo, Jose, Somolinos-Simón, Francisco J, Hernando, Maria E, Wang, Junfeng, Jiu, Li, Goettsch, Wim G, van der Kallen, Carla J H, Koster, Annemarie, Schalkwijk, Casper G, de Vries, Hein, de Vries, Nanne K, Eussen, Simone J P M, Driessen, Johanna H M, Stehouwer, Coen D A, Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmaceutical Policy and Regulation, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Werkman, Nikki C C, García-Sáez, Gema, Nielen, Johannes T H, Tapia-Galisteo, Jose, Somolinos-Simón, Francisco J, Hernando, Maria E, Wang, Junfeng, Jiu, Li, Goettsch, Wim G, van der Kallen, Carla J H, Koster, Annemarie, Schalkwijk, Casper G, de Vries, Hein, de Vries, Nanne K, Eussen, Simone J P M, Driessen, Johanna H M, and Stehouwer, Coen D A

Published
2024

17. The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study

Author

Geraets, Anouk F. J., Köhler, Sebastian, Muzambi, Rutendo, Schalkwijk, Casper G., Oenema, Anke, Eussen, Simone J. P. M., Dagnelie, Pieter C., Stehouwer, Coen D. A., Schaper, Nicolaas C., Henry, Ronald M. A., van der Kallen, Carla J. H., Wesselius, Anke, Koster, Annemarie, Verhey, Frans R. J., and Schram, Miranda T.

Published
2020
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18. Validated inference of smoking habits from blood with a finite DNA methylation marker set

Author

BIOS Consortium, Maas, Silvana C. E., Vidaki, Athina, Wilson, Rory, Teumer, Alexander, Liu, Fan, van Meurs, Joyce B. J., Uitterlinden, André G., Boomsma, Dorret I., de Geus, Eco J. C., Willemsen, Gonneke, van Dongen, Jenny, van der Kallen, Carla J. H., Slagboom, P. Eline, Beekman, Marian, van Heemst, Diana, van den Berg, Leonard H., Duijts, Liesbeth, Jaddoe, Vincent W. V., Ladwig, Karl-Heinz, Kunze, Sonja, Peters, Annette, Ikram, M. Arfan, Grabe, Hans J., Felix, Janine F., Waldenberger, Melanie, Franco, Oscar H., Ghanbari, Mohsen, and Kayser, Manfred

Published
2019

19. Validating biomarkers and models for epigenetic inference of alcohol consumption from blood

Author

Maas, Silvana C. E., Vidaki, Athina, Teumer, Alexander, Costeira, Ricardo, Wilson, Rory, van Dongen, Jenny, Beekman, Marian, Völker, Uwe, Grabe, Hans J., Kunze, Sonja, Ladwig, Karl-Heinz, van Meurs, Joyce B. J., Uitterlinden, André G., Voortman, Trudy, Boomsma, Dorret I., Slagboom, P. Eline, van Heemst, Diana, van der Kallen, Carla J. H., van den Berg, Leonard H., Waldenberger, Melanie, Völzke, Henry, Peters, Annette, Bell, Jordana T., Ikram, M. Arfan, Ghanbari, Mohsen, and Kayser, Manfred

Published
2021
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21. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., de Jong, Marit, Vos, Rimke C., Bots, Michiel L., Reulen, Jos P. H., Houben, Alfons J. H. M., Webers, Carroll A. B., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Peters, Sanne A. E., and Stehouwer, Coen D. A.

Published
2021
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24. Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study

Author

den Biggelaar, Louise J. C. J., Sep, Simone J. S., Mari, Andrea, Ferrannini, Ele, van Dongen, Martien C. J. M., Wijckmans, Nicole E. G., Schram, Miranda T., van der Kallen, Carla J., Schaper, Nicolaas, Henry, Ronald M. A., van Greevenbroek, Marleen M., Stehouwer, Coen D. A., and Eussen, Simone J. P. M.

Published
2020
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26. Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Author

Liu, Jun, Lahousse, Lies, Nivard, Michel G., Bot, Mariska, Chen, Lianmin, van Klinken, Jan Bert, Thesing, Carisha S., Beekman, Marian, van den Akker, Erik Ben, Slieker, Roderick C., Waterham, Eveline, van der Kallen, Carla J. H., de Boer, Irene, Li-Gao, Ruifang, Vojinovic, Dina, Amin, Najaf, Radjabzadeh, Djawad, Kraaij, Robert, Alferink, Louise J. M., Murad, Sarwa Darwish, Uitterlinden, André G., Willemsen, Gonneke, Pool, Rene, Milaneschi, Yuri, van Heemst, Diana, Suchiman, H. Eka D., Rutters, Femke, Elders, Petra J. M., Beulens, Joline W. J., van der Heijden, Amber A. W. A., van Greevenbroek, Marleen M. J., Arts, Ilja C. W., Onderwater, Gerrit L. J., van den Maagdenberg, Arn M. J. M., Mook-Kanamori, Dennis O., Hankemeier, Thomas, Terwindt, Gisela M., Stehouwer, Coen D. A., Geleijnse, Johanna M., ‘t Hart, Leen M., Slagboom, P. Eline, van Dijk, Ko Willems, Zhernakova, Alexandra, Fu, Jingyuan, Penninx, Brenda W. J. H., Boomsma, Dorret I., Demirkan, Ayşe, Stricker, Bruno H. C., and van Duijn, Cornelia M.

Published
2020
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27. Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Author

van der Heide, Frank C T, Mokhtar, Sara, Khanna, Anjani, Said, Mozhda, Henry, Ronald M A, Kroon, Abraham A, Dagnelie, Pieter C, Eussen, Simone J P M, Berendschot, Tos T J M, Schouten, Jan S A G, Schram, Miranda T, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Wesselius, Anke, Savelberg, Hans H C M, Schaper, Nicolaas C, Webers, Carroll A B, Stehouwer, Coen D A, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, RS: MHeNs - R3 - Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: HVC Pieken Maastricht Studie (8), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, MUMC+: MA Endocrinologie (9), MUMC+: University Eye Center Maastricht (3), MUMC+: *MA Oogheelkunde (3), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), and MUMC+: MA Maag Darm Lever (9)

Subjects
Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology
Abstract

BACKGROUND: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.OBJECTIVE: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.METHODS: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).RESULTS: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.CONCLUSION: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.

Published
2023

28. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study.

Author

Beran, Magdalena, van Gennip, April C. E., Stehouwer, Coen D. A., Jansen, Jacobus F. A., Gupta, Monideepa D., Houben, Alfons J. H. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., Wesselius, Anke, Schalkwijk, Casper G., Backes, Walter H., de Jong, Joost J. A., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Köhler, Sebastian, Vonk, Jet M. J., Geerlings, Mirjam I., Schram, Miranda T., and van Sloten, Thomas T.

Published
2024
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29. FRI615 The 1-Hour OGTT Plasma Glucose As A Biomarker Of β-cell Function

Author

Thomas Legvold, Brian, primary, Zhang, Amanda, additional, Marie Utzschneider, Kristina, additional, Kyung Rhee, Mary, additional, Staimez, Lisa R, additional, Easley, Kirk A, additional, Van Greevenbroek, Marleen M J, additional, Van Der Kallen, Carla J H, additional, Schalkwijk, Casper G, additional, Stehouwer, Coen D A, additional, and Phillips, Lawrence S, additional

Published
2023
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30. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study

Author

van der Heide, Frank C. T., primary, Steens, Indra L. M., additional, Limmen, Betsie, additional, Mokhtar, Sara, additional, van Boxtel, Martin P. J., additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Kroon, Abraham A., additional, van der Kallen, Carla J. H., additional, Dagnelie, Pieter C., additional, van Dongen, Martien C. J. M., additional, Eussen, Simone J. P. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, van Sloten, Thomas T., additional, Jansen, Jacobus F. A., additional, Backes, Walter H., additional, and Stehouwer, Coen D. A., additional

Published
2023
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36. The association between the food environment and adherence to healthy diet quality: the Maastricht Study

Author

Chan, Jeffrey Alexander, primary, Koster, Annemarie, additional, Eussen, Simone JPM, additional, Pinho, Maria Gabriela M, additional, Lakerveld, Jeroen, additional, Stehouwer, Coen DA, additional, Dagnelie, Pieter C, additional, van der Kallen, Carla J, additional, van Greevenbroek, Marleen MJ, additional, Wesselius, Anke, additional, and Bosma, Hans, additional

Published
2023
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39. The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study

Author

Foreman, Yuri D., Brouwers, Martijn C. G. J., Berendschot, Tos T. J. M., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., van Greevenbroek, Marleen M. J., Henry, Ronald M. A., Houben, Alfons J. H. M., van der Kallen, Carla J. H., Kroon, Abraham A., Reesink, Koen D., Schram, Miranda T., Schaper, Nicolaas C., and Stehouwer, Coen D. A.

Published
2019
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40. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study.

Author

van der Heide, Frank C. T., Steens, Indra L. M., Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P. J., Schram, Miranda T., Köhler, Sebastian, Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Koster, Annemarie, van Sloten, Thomas T., Jansen, Jacobus F. A., Backes, Walter H., and Stehouwer, Coen D. A.

Abstract

INTRODUCTION: The retina may provide non‐invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross‐sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Arterial stiffness is associated with depression in middle-aged men--the Maastricht Study

Author

Onete, Veronica, Henry, Ronald M., Sep, Simone J.S., Koster, Annemarie, van der Kallen, Carla J., Dagnelie, Pieter C., Schaper, Nicolaas, Kohler, Sebastian, Reesink, Koen, Stehouwer, Coen D.A., and Schram, Miranda T.

Subjects
Major depressive disorder -- Causes of, Middle aged men -- Psychological aspects -- Health aspects, Arteries -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. Methods: We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study. Logistic and negative binominal models were adjusted for age, type 2 diabetes mellitus (T2DM), mean arterial pressure (MAP) and CVD risk factors. Results: We included 2757 participants in our analyses (48.8% men, mean age 59.8 [+ or -] 8.1 yr, 27% T2DM). We found that cfPWV was associated with MDD in men (fully adjusted odds ratio [OR] 2.36, 95% confidence interval [CI] 1.45-3.84), but not in women (OR 1.57, 95% CI 0.93-2.66), aged 60 years or younger. The ORs were not significant in individuals older than 60 years (men: OR 1.03, 95% CI 0.63-1.68; women: OR 0.64, 95% CI 0.32-1.31). Similarly, cfPWV was associated with a higher PHQ-9 score in men (rate ratio 1.28, 95% CI 1.09-1.52), but not in women (rate ratio 1.11,95% CI 0.99-1.23), aged 60 years or younger. Associations were not significant in individuals older than 60 years (men: rate ratio 0.96, 95% CI 0.84-1.08; women: rate ratio 1.00, 95% CI 0.90-1.12). Limitations: We cannot rule out reversed causation in this cross-sectional study. Conclusion: Greater aortic stiffness is associated with MDD and depressive symptoms among middle-aged men and to a lesser extent in women, whereas this association was not observed in old age., Introduction Arterial stiffening is considered a potential mechanism that could underlie the consistently observed association between depression and cardiovascular disease (CVD). (1-3) Arterial stiffening may cause damage to the cerebral [...]

Published
2018
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43. Reliability of HR-pQCT Derived Cortical Bone Structural Parameters When Using Uncorrected Instead of Corrected Automatically Generated Endocortical Contours in a Cross-Sectional Study: The Maastricht Study

Author

de Waard, Ellis A. C., Sarodnik, Cindy, Pennings, Alexander, de Jong, Joost J. A., Savelberg, Hans H. C. M., van Geel, Tineke A., van der Kallen, Carla J., Stehouwer, Coen D. A., Schram, Miranda T., Schaper, Nicolaas, Dagnelie, Pieter C., Geusens, Piet P. M. M., Koster, Annemarie, van Rietbergen, Bert, and van den Bergh, Joop P. W.

Published
2018
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44. Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression and quality of life: The Maastricht Study

Author

de Ritter, Rianneke, primary, Sep, Simone J. S., additional, van der Kallen, Carla J. H., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, Eussen, Simone J. P. M., additional, Dagnelie, Pieter C., additional, van Boxtel, Martin, additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Martens, Jordi A. J., additional, Snobl, Lucia, additional, Vos, Rimke C., additional, Stehouwer, Coen D. A., additional, and Peters, Sanne A. E., additional

Published
2023
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45. Circulating and adipose tissue immune cells in tissue‐specific insulin resistance in humans with overweight and obesity

Author

Trouwborst, Inez, primary, Wouters, Kristiaan, additional, Jocken, Johan W., additional, Jardon, Kelly M., additional, Gijbels, Anouk, additional, Dagnelie, Pieter C., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J., additional, Stehouwer, Coen D. A., additional, Schalkwijk, Casper G., additional, Richard, Nathalie, additional, Bendik, Igor, additional, Afman, Lydia A., additional, Blaak, Ellen E., additional, and Goossens, Gijs H., additional

Published
2023
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46. Circulating and adipose tissue immune cells in tissue-specific insulin resistance in humans with overweight and obesity

Author

Trouwborst, Inez, Wouters, Kristiaan, Jocken, Johan W., Jardon, Kelly M., Gijbels, Anouk, Dagnelie, Pieter C., van Greevenbroek, Marleen M.J., van der Kallen, Carla J., Stehouwer, Coen D.A., Schalkwijk, Casper G., Richard, Nathalie, Bendik, Igor, Afman, Lydia A., Blaak, Ellen E., Goossens, Gijs H., Trouwborst, Inez, Wouters, Kristiaan, Jocken, Johan W., Jardon, Kelly M., Gijbels, Anouk, Dagnelie, Pieter C., van Greevenbroek, Marleen M.J., van der Kallen, Carla J., Stehouwer, Coen D.A., Schalkwijk, Casper G., Richard, Nathalie, Bendik, Igor, Afman, Lydia A., Blaak, Ellen E., and Goossens, Gijs H.

Abstract

Objective: A proinflammatory adipose tissue (AT) microenvironment and systemic low-grade inflammation may differentially affect tissue-specific insulin sensitivity. This study investigated the relationships of abdominal subcutaneous AT (aSAT) and circulating immune cells, aSAT gene expression, and circulating inflammatory markers with liver and skeletal muscle insulin sensitivity in people with overweight and obesity. Methods: Individuals with overweight and obesity from the PERSonalized Glucose Optimization Through Nutritional Intervention (PERSON) Study (n = 219) and the Maastricht Study (replication cohort; n = 1256) underwent a seven-point oral glucose tolerance test to assess liver and muscle insulin sensitivity, and circulating inflammatory markers were determined. In subgroups, flow cytometry was performed to identify circulating and aSAT immune cells, and aSAT gene expression was evaluated. Results: The relative abundances of circulating T cells, nonclassical monocytes, and CD56dim CD16+ natural killer cells were inversely associated with liver, but not muscle, insulin sensitivity in the PERSON Study. The inverse association between circulating (classical) monocytes and liver insulin sensitivity was confirmed in the Maastricht Study. In aSAT, immune cell populations were not related to insulin sensitivity. Furthermore, aSAT gene expression of interleukin 6 and CD14 was positively associated with muscle, but not liver, insulin sensitivity. Conclusions: The present findings demonstrate that circulating immune cell populations and inflammatory gene expression in aSAT show distinct associations with liver and muscle insulin sensitivity.

Published
2023

48. The association between the food environment and adherence to healthy diet quality:The Maastricht Study

Author

Chan, Jeffrey Alexander, Koster, Annemarie, Eussen, Simone Jpm, Pinho, Maria G. M., Lakerveld, Jeroen, Stehouwer, Coen Da, Dagnelie, Pieter C., Schram, Miranda T., van der Kallen, Carla J., van Greevenbroek, Marleen Mj, Wesselius, Anke, and Bosma, Hans

Abstract

Objective: The purpose of this study is to determine if healthier neighborhood food environments are associated with healthier diet quality. Design: This was a cross-sectional study using linear regression models to analyze data from The Maastricht Study. Diet quality was assessed using data collected with a food frequency questionnaire to calculate the Dutch Healthy Diet (DHD). A buffer zone encompassing a 1000m radius was created around each participant home address. The Food Environment Healthiness Index (FEHI) was calculated using a Kernel density analysis within the buffers of available food outlets. The association between the FEHI and the DHD score were analyzed and adjusted for socioeconomic variables. Setting: The region of Maastricht including the surrounding food retailers in the Netherlands. Participants: 7,367 subjects ages 40-75 in the south of the Netherlands. Results: No relationship was identified between either the FEHI (B =.62; 95% CI = -2.54, 3.78) or individual food outlets, such as fast food (B = -.07; 95% CI = -.20,.07), and diet quality. Similar null findings using the FEHI were identified at the 500m (B =.95; 95% CI = -.85, 2.75) and 1500m (B = 1.57; 95% CI = -3.30, 6.44) buffer. There was also no association between the food environment and individual items of the DHD including fruits, vegetables, and sugar sweetened beverages. Conclusion: The food environment in the Maastricht area appeared marginally unhealthy, but the differences in the food environment were not related to the quality of food that participants reported as intake.

Published
2023

50. Daily patterns of physical activity, sedentary behavior, and prevalent and incident depression—The Maastricht Study

Author

Gianfredi, Vincenza, primary, Schaper, Nicolaas C., additional, Odone, Anna, additional, Signorelli, Carlo, additional, Amerio, Andrea, additional, Eussen, Simone J. P. M., additional, Köhler, Sebastian, additional, Savelberg, Hans H. C. M., additional, Stehouwer, Coen D. A., additional, Dagnelie, Pieter C., additional, Henry, Ronald M. A., additional, van der Kallen, Carla J. H., additional, van Greevenbroek, Marleen M. J., additional, Schram, Miranda T., additional, and Koster, Annemarie, additional

Published
2022
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