Author: "Zhou, Xiangtian" / Publication Year Range: Last 50 years - Searchworks@Jio Institute Digital Library Search Results

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473 results on '"Zhou, Xiangtian"'

1. Efficient Pyramid Channel Attention Network for Pathological Myopia Recognition

Author: Zhang, Xiaoqing, Zhao, Jilu, Li, Yan, Wu, Hao, Zhou, Xiangtian, and Liu, Jiang
Subjects: Computer Science - Computer Vision and Pattern Recognition
Abstract: Pathological myopia (PM) is the leading ocular disease for impaired vision worldwide. Clinically, the characteristic of pathology distribution in PM is global-local on the fundus image, which plays a significant role in assisting clinicians in diagnosing PM. However, most existing deep neural networks focused on designing complex architectures but rarely explored the pathology distribution prior of PM. To tackle this issue, we propose an efficient pyramid channel attention (EPCA) module, which fully leverages the potential of the clinical pathology prior of PM with pyramid pooling and multi-scale context fusion. Then, we construct EPCA-Net for automatic PM recognition based on fundus images by stacking a sequence of EPCA modules. Moreover, motivated by the recent pretraining-and-finetuning paradigm, we attempt to adapt pre-trained natural image models for PM recognition by freezing them and treating the EPCA and other attention modules as adapters. In addition, we construct a PM recognition benchmark termed PM-fundus by collecting fundus images of PM from publicly available datasets. The comprehensive experiments demonstrate the superiority of our EPCA-Net over state-of-the-art methods in the PM recognition task. The results also show that our method based on the pretraining-and-finetuning paradigm achieves competitive performance through comparisons to part of previous methods based on traditional fine-tuning paradigm with fewer tunable parameters, which has the potential to leverage more natural image foundation models to address the PM recognition task in limited medical data regime., Comment: 37 pages
Published: 2023

2. Influencing factors of the approval of the Young Scientists Fund of National Natural Science Foundation of China: a case study of Shanghai Jiao Tong University School of Medicine

Author: CHEN Lihong, WANG Yan, ZHOU Xiangtian, ZHENG Junke, and YAN Xiaoxiang
Subjects: young medical talent, national natural science foundation of china, young scientists fund, influence factor, Medicine
Abstract: Objective·In view of the low funding rate of the Young Scientists Fund of National Natural Science Foundation of China in the medical field, this research conducted an in-depth investigation of the applicants in a medical school and quantitatively analyzed the influencing factors of project establishment, so as to provide reference for further improving the quality of project application and strengthening the training of young medical talents.Methods·A cross-sectional survey was used to select applicants from secondary schools of Shanghai Jiao Tong University School of Medicine and its 13 affiliated hospitals who had experience in applying for the fund from 2020 to 2022. Logistic stepwise regression model was applied to modeling and analysis by using the project application result as the dependent variable and the applicants' basic information and application status as independent variables.Results·The analysis results of 921 applicants showed that educational background (OR=1.86, 95%CI 1.14‒3.04), graduate university (OR=2.45, 95%CI 1.47‒4.08), sufficient preliminary work foundation (OR=4.22, 95%CI 2.44‒7.29), average impact factor of representative works (OR=1.10, 95%CI 1.04‒1.17), and total self-evaluation score of application documents (OR=1.06, 95%CI 1.04‒1.08) were the main influencing factors for project approval. The average impact factor and the highest impact factor of the approved representative works showed an increasing trend year by year. In addition, the influencing factors for the approval of young doctors and full-time researchers were different. The longer the graduation time of young doctors, the lower the approval rate.Conclusion·The funding rate of Young Scientists Fund is low, and the requirements for scientific research achievements are increasing year by year. Attention should be paid to early accumulation and improving the quality of application writing. Further measures should be taken to strengthen the early training of young medical talents, improve cultivation measures and consolidate research foundations.
Published: 2024
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3. IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Author: Ostrin, Lisa A, Harb, Elise, Nickla, Debora L, Read, Scott A, Alonso-Caneiro, David, Schroedl, Falk, Kaser-Eichberger, Alexandra, Zhou, Xiangtian, and Wildsoet, Christine F
Subjects: Eye Disease and Disorders of Vision, Eye, Animals, Humans, Axial Length, Eye, Choroid, Bruch Membrane, Myopia, Models, Animal, Tomography, Optical Coherence, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry
Abstract: The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient.
Published: 2023

4. Efficient pyramid channel attention network for pathological myopia recognition with pretraining-and-finetuning

Author: Zhang, Xiaoqing, Zhao, Jilu, Li, Yan, Wu, Hao, Zhou, Xiangtian, and Liu, Jiang
Published: 2024
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5. Augmentation of scleral glycolysis promotes myopia through histone lactylation

Author: Lin, Xiaolei, Lei, Yi, Pan, Miaozhen, Hu, Changxi, Xie, Bintao, Wu, Wenjing, Su, Jianzhong, Li, Yating, Tan, Yuhan, Wei, Xiaohuan, Xue, Zhengbo, Xu, Ruiyan, Di, Mengqi, Deng, Hanyu, Liu, Shengcong, Yang, Xingxing, Qu, Jia, Chen, Wei, Zhou, Xiangtian, and Zhao, Fei
Published: 2024
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6. Lactate/lactylation in ocular development and diseases

Author: Chai, Peiwei, Zhao, Fei, Jia, Renbing, Zhou, Xiangtian, and Fan, Xianqun
Published: 2024
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7. Choroidal blood perfusion could predict the sensitivity of myopia formation in Guinea pigs

Author: Yang, Yaozhen, Chen, Mengxi, Yao, Xinyuan, Wang, Jiao, Shi, Jiajia, Wang, Yuanyuan, Tian, Jinmin, Zhou, Xiangtian, Qu, Jia, and Zhang, Sen
Published: 2023
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8. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.

Author: Yu, Jialing, Liang, Xiaoyang, Ji, Yanchun, Ai, Cheng, Liu, Junxia, Zhu, Ling, Nie, Zhipeng, Jin, Xiaofen, Wang, Chenghui, Zhang, Juanjuan, Zhao, Fuxin, Mei, Shuang, Zhao, Xiaoxu, Zhou, Xiangtian, Zhang, Minglian, Wang, Meng, Huang, Taosheng, Jiang, Pingping, and Guan, Min-Xin
Subjects: Animals, Mice, Knockout, Humans, Mice, Optic Atrophy, Hereditary, Leber, Mitochondrial Proteins, Amino Acid Substitution, Mutation, Missense, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Female, Male, Adenosine Triphosphatases, LIM Domain Proteins, Genetic diseases, Genetics, Mitochondria, Molecular pathology, Ophthalmology, Eye Disease and Disorders of Vision, Neurosciences, Pediatric, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Medical and Health Sciences, Immunology
Abstract: Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease. X-linked nuclear modifiers were proposed to modify the phenotypic manifestation of LHON-associated mitochondrial DNA (mtDNA) mutations. By whole-exome sequencing, we identified the X-linked LHON modifier (c.157C>T, p.Arg53Trp) in PRICKLE3 encoding a mitochondrial protein linked to biogenesis of ATPase in 3 Chinese families. All affected individuals carried both ND4 11778G>A and p.Arg53Trp mutations, while subjects bearing only a single mutation exhibited normal vision. The cells carrying the p.Arg53Trp mutation exhibited defective assembly, stability, and function of ATP synthase, verified by PRICKLE3-knockdown cells. Coimmunoprecipitation indicated the direct interaction of PRICKLE3 with ATP synthase via ATP8. Strikingly, cells bearing both p.Arg53Trp and m.11778G>A mutations displayed greater mitochondrial dysfunction than those carrying only a single mutation. This finding indicated that the p.Arg53Trp mutation acted in synergy with the m.11778G>A mutation and deteriorated mitochondrial dysfunctions necessary for the expression of LHON. Furthermore, we demonstrated that Prickle3-deficient mice exhibited pronounced ATPase deficiencies. Prickle3-knockout mice recapitulated LHON phenotypes with retinal deficiencies, including degeneration of retinal ganglion cells and abnormal vasculature. Our findings provided new insights into the pathophysiology of LHON that were manifested by interaction between mtDNA mutations and X-linked nuclear modifiers.
Published: 2020

9. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author: Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, and Ohno-Matsui, Kyoko
Published: 2023
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10. Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia

Author: Qian, Kang-Wei, Li, Yun-Yun, Wu, Xiao-Hua, Gong, Xue, Liu, Ai-Lin, Chen, Wen-Hao, Yang, Zhe, Cui, Ling-Jie, Liu, Yun-Feng, Ma, Yuan-Yuan, Yu, Chen-Xi, Huang, Furong, Wang, Qiongsi, Zhou, Xiangtian, Qu, Jia, Zhong, Yong-Mei, Yang, Xiong-Li, and Weng, Shi-Jun
Published: 2022
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11. Dietary ω-3 polyunsaturated fatty acids are protective for myopia

Author: Pan, Miaozhen, Zhao, Fei, Xie, Bintao, Wu, Hao, Zhang, Sen, Ye, Cong, Guan, Zhenqi, Kang, Lin, Zhang, Yuqing, Zhou, Xuan, Lei, Yi, Wang, Qi, Wang, Li, Yang, Fan, Zhao, Chenchen, Qu, Jia, and Zhou, Xiangtian
Published: 2021

12. Form-deprivation myopia downregulates calcium levels in retinal horizontal cells in mice

Author: Li, Qihang, Zhu, He, Fan, Miaomiao, Sun, Jing, Reinach, Peter S., Wang, Yuhan, Qu, Jia, Zhou, Xiangtian, and Zhao, Fuxin
Published: 2022
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13. Differences in choroidal responses to near work between myopic children and young adults

Author: Liu, Mengqi, primary, Wang, Yuanyuan, additional, Li, Haoer, additional, Zhao, Yunpeng, additional, Ma, Min, additional, Xu, Shihan, additional, Wei, Xiaohuan, additional, Xu, Ruiyan, additional, Tian, Ruikang, additional, Zhou, Xiangtian, additional, and Wu, Hao, additional
Published: 2024
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14. Choroidal vascular changes in early-stage myopic maculopathy from deep learning choroidal analysis: a hospital-based SS-OCT study.

Author: Li, Yan, Li, Haoer, Rui, Xue, Wang, Yuan, Zhu, Shenju, Huang, Mengge, Liang, Jianqiang, Zhu, Yangfeifei, Shi, Jiajia, Yu, Le, Huang, Shenghai, Yang, Chun, Dong, Mengmeng, Gao, Hebei, Shen, Meixiao, Wu, Hao, and Zhou, Xiangtian
Published: 2024
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15. Up-Regulation of Matrix Metalloproteinase-2 by Scleral Monocyte–Derived Macrophages Contributes to Myopia Development

Author: Zhao, Fei, Wu, Hao, Reinach, Peter S., Wu, Yi, Zhai, Ying, Lei, Yi, Ma, Li, Su, Yongchao, Chen, Yizhong, Li, Fen, Liu, Xing, Srinivasalu, Nethrajeith, Qu, Jia, and Zhou, Xiangtian
Published: 2020
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16. Choroidal blood perfusion as a potential “rapid predictive index” for myopia development and progression

Author: Zhou, Xiangtian, Ye, Cong, Wang, Xiaoyan, Zhou, Weihe, Reinach, Peter, and Qu, Jia
Published: 2021
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17. Author Correction: A role of color vision in emmetropization in C57BL/6J mice

Author: Yang, Jinglei, Yang, Li, Chen, Rongfang, Zhu, Yun, Wang, Siyao, Hou, Xueqin, Wei, Bei, Wang, Qiongsi, Liu, Yue, Qu, Jia, and Zhou, Xiangtian
Published: 2021
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18. Spontaneously Myopic Guinea Pig: Model of Early Pathologic Myopia

Author: Zhang, Yue, primary, Tang, Wenyu, additional, Liang, Jianqiang, additional, Zhou, Xiangtian, additional, Chen, Si, additional, and Zhi, Zhina, additional
Published: 2023
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19. The role of retinal dopamine D1 receptors in ocular growth and myopia development in mice

Author: Shu, Ziheng, primary, Chen, Kaijie, additional, Wang, Qiongsi, additional, Wu, Honglin, additional, Zhu, Yangfeifei, additional, Tian, Ruikang, additional, Yan, Wenjun, additional, Huang, Qin, additional, Zhang, Chunlan, additional, Xiong, Weiwei, additional, Qu, Jia, additional, Zhou, Xiangtian, additional, and Huang, Furong, additional
Published: 2023
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20. Scleral hypoxia is a target for myopia control

Author: Wu, Hao, Chen, Wei, Zhao, Fei, Zhou, Qingyi, Reinach, Peter S., Deng, Lili, Ma, Li, Luo, Shumeng, Srinivasalu, Nethrajeith, Pan, Miaozhen, Hu, Yang, Pei, Xiaomeng, Sun, Jing, Ren, Ran, Xiong, Yinghui, Zhou, Zhonglou, Zhang, Sen, Tian, Geng, Fang, Jianhuo, Zhang, Lina, Lang, Jidong, Wu, Deng, Zeng, Changqing, Qu, Jia, and Zhou, Xiangtian
Published: 2018

21. Cause and Effect Relationship between Changes in Scleral Matrix Metallopeptidase-2 Expression and Myopia Development in Mice

Author: Zhao, Fei, Zhou, Qingyi, Reinach, Peter S., Yang, Jinglei, Ma, Li, Wang, Xiaojun, Wen, Yingying, Srinivasalu, Nethrajeith, Qu, Jia, and Zhou, Xiangtian
Published: 2018
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22. Myopia

Author: Baird, Paul N., Saw, Seang-Mei, Lanca, Carla, Guggenheim, Jeremy A., Smith III, Earl L., Zhou, Xiangtian, Matsui, Kyoko-Ohno, Wu, Pei-Chang, Sankaridurg, Padmaja, Chia, Audrey, Rosman, Mohamad, Lamoureux, Ecosse L., Man, Ryan, and He, Mingguang
Published: 2020
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23. A role of color vision in emmetropization in C57BL/6J mice

Author: Yang, Jinglei, Yang, Li, Chen, Rongfang, Zhu, Yun, Wang, Siyao, Hou, Xueqin, Wei, Bei, Wang, Qiongsi, Liu, Yue, Qu, Jia, and Zhou, Xiangtian
Published: 2020
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24. Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations

Author: Han, Xiaotong, primary, Pan, Siyu, additional, Liu, Jialin, additional, Ding, Xiaohu, additional, Lin, Xingyan, additional, Wang, Decai, additional, Xie, Zhi, additional, Zeng, Changqing, additional, Liu, Fan, additional, He, Mingguang, additional, Zhou, Xiangtian, additional, Liu, Tianzi, additional, Luo, Lixia, additional, and Liu, Yizhi, additional
Published: 2023
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25. Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study

Author: Wu, Hao, primary, Peng, Tianli, additional, Zhou, Weihe, additional, Huang, Zihan, additional, Li, Hongyu, additional, Wang, Tengfei, additional, Zhang, Jingwei, additional, Zhang, Kou, additional, Li, Haoer, additional, Zhao, Yunpeng, additional, Qu, Jia, additional, Lu, Fan, additional, Zhou, Xiangtian, additional, and Jiang, Jun, additional
Published: 2023
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26. Dopamine signaling and myopia development: What are the key challenges

Author: Zhou, Xiangtian, Pardue, Machelle T., Iuvone, P. Michael, and Qu, Jia
Published: 2017
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27. Controllable synthesis of anisotropic silica/polymer composite particles via seeded dispersion polymerization

Author: Zhang, Zhen, Shao, Hong, Zhou, Xiangtian, Zhao, Linling, Liu, Huarong, Ji, Xiang, and Liu, Hewen
Published: 2017
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28. Conjunctival MUC5AC+ goblet cell index: relationship with corneal nerves and dry eye

Author: Chao, Cecilia, Golebiowski, Blanka, Stapleton, Fiona, Zhou, Xiangtian, Chen, Shihao, and Madigan, Michele C.
Published: 2018
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29. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author: Clark, Rosie, primary, Lee, Samantha Sze-Yee, additional, Du, Ran, additional, Wang, Yining, additional, Kneepkens, Sander C.M., additional, Charng, Jason, additional, Huang, Yu, additional, Hunter, Michael L., additional, Jiang, Chen, additional, Tideman, J.Willem L., additional, Melles, Ronald B., additional, Klaver, Caroline C.W., additional, Mackey, David A., additional, Williams, Cathy, additional, Choquet, Hélène, additional, Ohno-Matsui, Kyoko, additional, Guggenheim, Jeremy A., additional, Bailey-Wilson, Joan E., additional, Baird, Paul N., additional, Barathi, Veluchamy A., additional, Biino, Ginevra, additional, Burdon, Kathryn P., additional, Campbell, Harry, additional, Chen, Li Jia, additional, Cheng, Ching-Yu, additional, Chew, Emily Y., additional, Craig, Jamie E., additional, Deangelis, Margaret M., additional, Delcourt, Cécile, additional, Ding, Xiaohu, additional, Fan, Qiao, additional, Fossarello, Maurizio, additional, Foster, Paul J., additional, Gharahkhani, Puya, additional, Guo, Xiaobo, additional, Haarman, Annechien E.G., additional, Haller, Toomas, additional, Hammond, Christopher J., additional, Han, Xikun, additional, Hayward, Caroline, additional, He, Mingguang, additional, Hewitt, Alex W., additional, Hoang, Quan, additional, Hysi, Pirro G., additional, Iglesias, Adriana I., additional, Igo, Robert P., additional, Iyengar, Sudha K., additional, Jonas, Jost B., additional, Kähönen, Mika, additional, Kaprio, Jaakko, additional, Khawaja, Anthony P., additional, Klein, Barbara E., additional, Lass, Jonathan H., additional, Lee, Kris, additional, Lehtimäki, Terho, additional, Lewis, Deyana, additional, Li, Qing, additional, Li, Shi-Ming, additional, Lyytikäinen, Leo-Pekka, additional, MacGregor, Stuart, additional, Martin, Nicholas G., additional, Meguro, Akira, additional, Metspalu, Andres, additional, Middlebrooks, Candace, additional, Miyake, Masahiro, additional, Mizuki, Nobuhisa, additional, Musolf, Anthony, additional, Nickels, Stefan, additional, Oexle, Konrad, additional, Pang, Chi Pui, additional, Pärssinen, Olavi, additional, Paterson, Andrew D., additional, Pfeiffer, Norbert, additional, Polasek, Ozren, additional, Rahi, Jugnoo S., additional, Raitakari, Olli, additional, Rudan, Igor, additional, Sahebjada, Srujana, additional, Saw, Seang-Mei, additional, Simpson, Claire L., additional, Stambolian, Dwight, additional, Tai, E-Shyong, additional, Tedja, Milly S., additional, Tideman, J. Willem L., additional, Tsujikawa, Akitaka, additional, van Duijn, Cornelia M., additional, Verhoeven, Virginie J.M., additional, Vitart, Veronique, additional, Wang, Ningli, additional, Wang, Ya Xing, additional, Wedenoja, Juho, additional, Wei, Wen Bin, additional, Williams, Katie M., additional, Wilson, James F., additional, Wojciechowski, Robert, additional, Yam, Jason C.S., additional, Yamashiro, Kenji, additional, Yap, Maurice K.H., additional, Yazar, Seyhan, additional, Yip, Shea Ping, additional, Young, Terri L., additional, Zhou, Xiangtian, additional, Allen, Naomi, additional, Aslam, Tariq, additional, Atan, Denize, additional, Barman, Sarah, additional, Barrett, Jenny, additional, Bishop, Paul, additional, Black, Graeme, additional, Bunce, Catey, additional, Carare, Roxana, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon, additional, Cipriani, Valentina, additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew, additional, Doney, Alexander, additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John, additional, Garway-Heath, David, additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy, additional, Hammond, Chris, additional, Hardcastle, Alison, additional, Harding, Simon, additional, Hogg, Ruth, additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Peng Tee, additional, Khawaja, Anthony, additional, Lascaratos, Gerassimos, additional, Littlejohns, Thomas, additional, Lotery, Andrew, additional, Luthert, Phil, additional, MacGillivray, Tom, additional, Mackie, Sarah, additional, McGuinness, Bernadette, additional, McKay, Gareth, additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James, additional, Muthy, Zaynah, additional, O'Sullivan, Eoin, additional, Owen, Chris, additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Pontikos, Nikolas, additional, Rahi, Jugnoo, additional, Rudnicka, Alicja, additional, Self, Jay, additional, Sergouniotis, Panagiotis, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Tapp, Robyn, additional, Thaung, Caroline, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vernon, Stephen, additional, Viswanathan, Ananth, additional, Williams, Katie, additional, Woodside, Jayne, additional, Yates, Max, additional, Yip, Jennifer, additional, and Zheng, Yalin, additional
Published: 2023
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30. Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation

Author: Ye, Rong, primary, Hu, Naijing, additional, Cao, Changchang, additional, Su, Ruibao, additional, Xu, Shihan, additional, Yang, Chen, additional, Zhou, Xiangtian, additional, and Xue, Yuanchao, additional
Published: 2023
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31. Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations

Author: Han, Xiaotong, Pan, Siyu, Liu, Jialin, Ding, Xiaohu, Lin, Xingyan, Wang, Decai, Xie, Zhi, Zeng, Changqing, Liu, Fan, He, Mingguang, Zhou, Xiangtian, Liu, Tianzi, Luo, Lixia, and Liu, Yizhi
Abstract: PurposeTo investigate genetic loci associated with ocular axial length (AL) in the Chinese population.MethodsA genome-wide association study meta-analysis was conducted in totalling 2644 Chinese individuals from 3 cohorts: the Guangzhou cohort (GZ, 537 high myopes and 151 hyperopes), Wenzhou cohort (334 high myopes and 6 hyperopes) and Guangzhou Twin Eye Study (1051 participants with normally distributed AL). Functional mapping was performed to annotate the significant signals, possible tissues and cell types by integrating available multiomics data. Logistic regression models using AL-associated SNPs were constructed to predict three AL status in GZ.ResultsTwo novel loci (1q25.2 FAM163Aand 7p22.2 SDK1) showed genome-wide significant associations with AL, together explaining 29.63% of AL variance in GZ. The two lead SNPs improved the prediction accuracy for AL status, especially for hyperopes. The frequencies of AL decreasing (less myopic) alleles of the two SNPs were lowest in East Asians as compared with other populations (rs17370084: fEAS=0.03, fEUR=0.24, fAFR=0.05; rs73046501: fEAS=0.06, fEUR=0.07, fAFR=0.20), which was in line with the global distribution of myopia. The cerebral cortex and gamma-aminobutyric acidergic interneurons showed possible functional involvement in myopia development, and the galactose metabolic pathways were significantly enriched.ConclusionOur study identified two population-specific novel loci for AL, expanding our understanding of the genetic basis of AL and providing evidence for a role of the nervous system and glucose metabolism in myopia pathogenesis.
Published: 2024
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32. Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2–Induced Increases in Collagen Expression

Author: Jiao, Shiming, primary, Reinach, Peter Sol, additional, Huang, Chengjie, additional, Yu, Lan, additional, Zhuang, Huiman, additional, Ran, Hongli, additional, Zhao, Fei, additional, Srinivasalu, Nethrajeith, additional, Qu, Jia, additional, and Zhou, Xiangtian, additional
Published: 2023
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33. Choroidal Blood Perfusion Could Predict the Sensitivity of Myopia Formation in Guinea Pigs

Author: Yang, Yaozhen, primary, Chen, Mengxi, additional, Yao, Xinyuan, additional, Wang, Jiao, additional, Shi, Jiajia, additional, Wang, Yuanyuan, additional, Tian, Jinmin, additional, Zhou, Xiangtian, additional, Qu, Jia, additional, and Zhang, Sen, additional
Published: 2023
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34. Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

Author: Musolf, Anthony M., Haarman, Annechien E. G., Luben, Robert N., Ong, Jue-Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Baird, Paul Nigel, Veluchamy, Amutha Barathi, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Cumberland, Phillippa M., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Evans, David M., Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Han, Xikun, He, Mingguang, Hewitt, Alex W., Hoang, Quan V., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Paterson, Andrew D., Pennell, Craig, Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Simpson, Claire L., Tai, E-Shyong, Tideman, J. Willem L., Tsujikawa, Akitaka, Wang, Ningli, Bin, Wei Wen, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Wang, Ya Xing, Yamashiro, Kenji, Yam, Jason C. S., Yap, Maurice K. H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Biino, Ginevra, Klein, Alison P., Duggal, Priya, Hayward, Caroline, Haller, Toomas, Metspalu, Andres, Wedenoja, Juho, Pärssinen, Olavi, Saw, Seang-Mei, Stambolian, Dwight, Hysi, Pirro G., Khawaja, Anthony P., Vitart, Veronique, Hammond, Christopher J., van Duijn, Cornelia M., Verhoeven, Virginie J. M., Klaver, Caroline C. W., and Bailey-Wilson, Joan E.
Subjects: genetic predisposition to disease, perinnölliset taudit, ympäristötekijät, taittovirheet, perinnöllisyyslääketiede, riskitekijät, quantitative trait, periytyvyys, genome-wide association studies, quantitative trait loci, perimä, silmätaudit, microarrays, perinnöllisyys
Abstract: Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopia (CREAM). The dataset consisted of over 27,000 total subjects from five cohorts of Indo-European and Eastern Asian ethnicity. We identified 129 unique genes associated with refractive error, many of which were replicated in multiple cohorts. Our best novel candidates included the retina expressed PDCD6IP, the circadian rhythm gene PER3, and P4HTM, which affects eye morphology. Future work will include functional studies and validation. Identification of genes contributing to refractive error and future understanding of their function may lead to better treatment and prevention of refractive errors, which themselves are important risk factors for various blinding conditions. peerReviewed
Published: 2023

35. Near work induces myopia in Guinea pigs

Author: Fu, Qian, primary, Zhang, Yue, additional, Chen, Linji, additional, Dong, Mengmeng, additional, Tang, Wenyu, additional, Chen, Si, additional, Qu, Jia, additional, Zhou, Xiangtian, additional, and Zhi, Zhina, additional
Published: 2022
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36. Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy

Author: Nie, Zhipeng, primary, Wang, Chenghui, additional, Chen, Jiarong, additional, Ji, Yanchun, additional, Zhang, Hongxing, additional, Zhao, Fuxin, additional, Zhou, Xiangtian, additional, and Guan, Min-Xin, additional
Published: 2022
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37. Sustained abnormality with recovery of COVID-19 convalescents: a 2-year follow-up study

Author: Lin, Hao, primary, Liu, Xueyuan, additional, Sun, Heqiang, additional, Zhang, Jie, additional, Dong, Shaobo, additional, Liu, Maoshun, additional, Li, Lei, additional, Tian, Jinmin, additional, Guo, Yaxin, additional, Gan, Jinxian, additional, Chen, Zhangfu, additional, Wang, Xin, additional, Lin, Ying, additional, Zhang, Danni, additional, Liu, Yaning, additional, Zhang, Xiaoshan, additional, Liu, Peipei, additional, Xu, Ke, additional, Zhou, Xiangtian, additional, Liang, Hao, additional, Gao, George F., additional, Liu, William J., additional, and Wu, Guizhen, additional
Published: 2022
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38. Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice

Author: Wu, Wenjing, primary, Su, Yongchao, additional, Hu, Changxi, additional, Tao, Huixin, additional, Jiang, Ying, additional, Zhu, Guandong, additional, Zhu, Jiadi, additional, Zhai, Ying, additional, Qu, Jia, additional, Zhou, Xiangtian, additional, and Zhao, Fei, additional
Published: 2022
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39. Structural and functional changes in corneal innervation after laser in situ keratomileusis and their relationship with dry eye

Author: Chao, Cecilia, Stapleton, Fiona, Zhou, Xiangtian, Chen, Shihao, Zhou, Shi, and Golebiowski, Blanka
Published: 2015
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40. Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation

Author: Lu, Juan, primary, An, Jianhong, additional, Wang, Jiawei, additional, Cao, Xiaowen, additional, Cao, Yuqing, additional, Huang, Chengjie, additional, Jiao, Shiming, additional, Yan, Dongsheng, additional, Lin, Xinhua, additional, and Zhou, Xiangtian, additional
Published: 2022
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41. Editorial: Advances in Management and Treatment of High Myopia and Its Complications

Author: Hoang, Quan V., primary, Chan, Xavier, additional, Zhu, Xiangjia, additional, Zhou, Xiangtian, additional, Shentu, Xiangchao, additional, and Lu, Yi, additional
Published: 2022
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42. Deletion of G Protein-Coupled Receptor 48 Leads to Ocular Anterior Segment Dysgenesis (ASD) through Down-Regulation of Pitx2

Author: Weng, Jinsheng, Luo, Jian, Cheng, Xuhong, Jin, Chang, Zhou, Xiangtian, Qu, Jia, Tu, LiLi, Ai, Di, Li, Dali, Wang, Jun, Martin, James F., Amendt, Brad A., and Liu, Mingyao
Published: 2008
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43. Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

Author: Hong, Yaqiang, primary, Zhang, Dake, additional, Zhou, Xiangtian, additional, Chen, Aili, additional, Abliz, Amir, additional, Bai, Jian, additional, Wang, Liang, additional, Hu, Qingtao, additional, Gong, Kenan, additional, Guan, Xiaonan, additional, Liu, Mengfei, additional, Zheng, Xinchang, additional, Lai, Shujuan, additional, Qu, Hongzhu, additional, Zhao, Fuxin, additional, Hao, Shuang, additional, Wu, Zhen, additional, Cai, Hong, additional, Hu, Shaoyan, additional, Ma, Yue, additional, Zhang, Junting, additional, Ke, Yang, additional, Wang, Qian-Fei, additional, Chen, Wei, additional, and Zeng, Changqing, additional
Published: 2022
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44. Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

Author: Huang, Furong, primary, Shu, Ziheng, additional, Huang, Qin, additional, Chen, Kaijie, additional, Yan, Wenjun, additional, Wu, Wenjing, additional, Yang, Jinglei, additional, Wang, Qiongsi, additional, Wang, Fengjiao, additional, Zhang, Chunlan, additional, Qu, Jia, additional, and Zhou, Xiangtian, additional
Published: 2022
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45. PDE4B Proposed as a High Myopia Susceptibility Gene in Chinese Population

Author: Zhao, Fuxin, primary, Chen, Wei, additional, Zhou, Hui, additional, Reinach, Peter S., additional, Wang, Yuhan, additional, Juo, Suh-Hang H., additional, Yang, Zhenglin, additional, Xue, Anquan, additional, Shi, Yi, additional, Liang, Chung-Ling, additional, Zeng, Changqing, additional, Qu, Jia, additional, and Zhou, Xiangtian, additional
Published: 2022
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46. Identification of novel loci influencing refractive error in East Asian populations using an extreme phenotype design

Author: Han, Xiaotong, primary, Liu, Tianzi, additional, Ding, Xiaohu, additional, Liu, Jialin, additional, Lin, Xingyan, additional, Wang, Decai, additional, Riaz, Moeen, additional, Baird, Paul N., additional, Xie, Zhi, additional, Cheng, Yuan, additional, Li, Yi, additional, Mori, Yuki, additional, Miyake, Masahiro, additional, Li, Hengtong, additional, Cheng, Ching-Yu, additional, Zeng, Changqing, additional, Ohno-Matsui, Kyoko, additional, Zhou, Xiangtian, additional, Liu, Fan, additional, and He, Mingguang, additional
Published: 2022
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47. Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs

Author: Zhou, Xuan, primary, Zhang, Sen, additional, Yang, Fan, additional, Yang, Yaozhen, additional, Huang, Qin, additional, Huang, Chengjie, additional, Qu, Jia, additional, and Zhou, Xiangtian, additional
Published: 2021
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48. The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leberʼs hereditary optic neuropathy-associated mitochondrial DNA mutation

Author: Jiang, Pingping, Jin, Xiaofen, Peng, Yanyan, Wang, Meng, Liu, Hao, Liu, Xiaoling, Zhang, Zengjun, Ji, Yanchun, Zhang, Juanjuan, Liang, Min, Zhao, Fuxin, Sun, Yan-Hong, Zhang, Minglian, Zhou, Xiangtian, Chen, Ye, Mo, Jun Qin, Huang, Taosheng, Qu, Jia, and Guan, Min-Xin
Published: 2016
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49. Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber's hereditary optic neuropathy.

Author: Nie, Zhipeng, Wang, Chenghui, Chen, Jiarong, Ji, Yanchun, Zhang, Hongxing, Zhao, Fuxin, Zhou, Xiangtian, and Guan, Min-Xin
Published: 2023
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50. Self-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse

Author: Kong, Fansheng, Li, Wensheng, Li, Xia, Zheng, Qinxiang, Dai, Xufeng, Zhou, Xiangtian, Boye, Sanford L., Hauswirth, William W., Qu, Jia, and Pang, Ji-jing
Published: 2010
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