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Background: The triglyceride glucose (TyG) index, as a reliable marker of insulin resistance, is associated with the incidence and poor prognosis of various cardiovascular diseases. However, the relationship between the TyG index and clinical outcomes in patients with severe aortic stenosis (AS) who underwent transcatheter aortic valve replacement (TAVR) remains unclear. Methods: This study consecutively enrolled 1569 patients with AS underwent TAVR at West China Hospital of Sichuan University between April 2014 and August 2023. The outcomes of interest included all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events (MACE). Multivariate adjusted Cox regression and restricted cubic splines (RCS) regression analyses were used to assess the associations between the TyG index and the clinical outcomes. The incremental prognostic value of the TyG index was further assessed by the time-dependent Harrell's C-index, integrated discrimination improvement (IDI) and the net reclassification improvement (NRI). Results: During a median follow-up of 1.09 years, there were 146, 70, and 196 patients experienced all-cause death, cardiovascular death, and MACE, respectively. After fully adjusting for confounders, a per-unit increase of TyG index was associated with a 441% (adjusted HR: 5.41, 95% CI: 4.01–7.32), 385% (adjusted HR: 4.85, 95% CI: 3.16–7.43), and 347% (adjusted HR: 4.47, 95% CI: 3.42–5.85) higher risk of all-cause mortality, cardiovascular mortality and MACE, respectively. The RCS regression analyses revealed a linear association between TyG index and endpoints (all P for non-linearity > 0.05) with 8.40 as the optimal binary cutoff point. Furthermore, adding TyG index to the basic risk model provided a significant incremental value in predicting poor prognosis (Time-dependent Harrell's C-index increased for all the endpoints; All-cause mortality, IDI: 0.11, P < 0.001; NRI: 0.32, P < 0.001; Cardiovascular mortality, IDI: 0.043, P < 0.001; NRI: 0.37, P < 0.001; MACE, IDI: 0.092, P < 0.001; NRI: 0.32, P < 0.001). Conclusions: In patients with severe AS receiving TAVR, there was a positive linear relationship between TyG index and poor prognosis, with 8.4 as the optimal bivariate cutoff value. Our findings suggest TyG index holds potential value for risk stratification and guiding therapeutic decisions in patients after TAVR. [ABSTRACT FROM AUTHOR]

The era of Industry 4.0 is gradually transforming our society into a data-driven one, which can help us uncover valuable information from accumulated data, thereby improving the level of social governance. The detection of anomalies, is crucial for maintaining societal trust and fairness, yet it poses significant challenges due to the ubiquity of anomalies and the difficulty in identifying them accurately. This paper aims to enhance the performance of the current Graph Convolutional Network (GCN)-based Graph Anomaly Detection (GAD) algorithm on datasets with extremely low proportions of anomalous labels. This goal is achieved through modifying the GCN network structure and conducting feature extraction, thus fully utilizing three types of information in the graph: node label information, node feature information, and edge information. Firstly, we theoretically demonstrate the relationship between label propagation and feature convolution, indicating that the Label Propagation Algorithm (LPA) can serve as a regularization penalty term for GCN, aiding in training and enabling learnable edge weights, providing a basis for incorporating node label information into GCN networks. Secondly, we introduce a method to aggregate node and edge features, thereby incorporating edge information into GCN networks. Finally, we design different GCN trainable weights for node features and co-embedding features. This design allows different features to be projected into different spaces, greatly enhancing model expressiveness. Experimental results on the DGraph dataset demonstrate superior AUC performance compared to baseline models, highlighting the feasibility and efficacy of the proposed approach in addressing GAD tasks in the scene with extremely low proportions of anomalous data. [ABSTRACT FROM AUTHOR]

Micro‐porous layer (MPL) is an essential component of the membrane electrode assembly in a direct methanol fuel cell (DMFC). It enables proton transport and maintains the stability of gas diffusion layers. The wettability and internal resistance of MPL directly affect the cell output power density. Herein, a hydrophilic MPL is developed on the anode side of DMFC by depositing Ag‐modified carbon nano‐fiber powder (CNFP). The modification improves the diffusion of methanol–water solution into the anode catalytic layer, leading to an increased catalytic reaction rate and output power density. Moreover, thanks to the lower electrical resistance of CNFP/Ag, the cell's charge transfer and mass transfer resistances can be reduced, which leverage the power densities at different concentrations. The experimental results show that the peak power density of the modified MPL is increased by 42.2% from 25.6$$ 25.6$$ to 32.0 mW cm−2$$ 32.0{\text{\hspace{0.17em}mW\hspace{0.17em}cm}}^{-2}$$. The charge transfer resistance is reduced by 34.8% from 2.784$2.784$ to 1.816 Ω$$ 1.816\text{\hspace{0.17em}}\Omega $$ and a reduction of 43.1% from 1.371$1.371$ to 0.780 Ω$$ 0.780\text{\hspace{0.17em}}\Omega $$ for the mass transfer resistance. [ABSTRACT FROM AUTHOR]

A double spherical shell (DSS) electric field sensor based on charge sensing has characteristics of small size and simple fabrication, which are appropriate for measuring complex electric field environments, but the sensitivity is low. To improve the sensitivity of the DSS electric field sensor, we theoretically analyze the effect of the diameter of the outer spherical shell opening on the sensitivity of the sensor. The sensors with outer spherical shell apertures of 2, 4, and 6 mm are designed and manufactured, and the sensor's sensitivity, linearity, hysteresis, and repeatability are tested. The relative error of the sensor is evaluated by measuring the rotational characteristics of the sensor. The experimental results show that the sensor sensitivity increases with the increase in hole diameter, while the sensor has good linearity, hysteresis, and repeatability after opening the hole. The rotational characteristics experiments' results show that the sensors' relative errors with different apertures are 18, 23, and 31%, respectively. The DSS open-hole structure is more suitable for electric field measurements than the conventional flat plate structure. [ABSTRACT FROM AUTHOR]