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Antiviral therapy can alleviate liver fibrosis in chronic hepatitis B, but it has a limited effect on advanced liver fibrosis/cirrhosis. Traditional Chinese medicine (TCM), particularly FuZheng HuaYu (FZHY) tablet, appears to have an antifibrotic effect, but its improving resolution of hepatitis b virus (HBV) -associated advanced fibrosis and experienced anti-viral treatment has not been investigated.To observe the safety and efficacy of adjunctive FZHY on the HBV-associated cirrhosis patients who received 2 years of entecavir but still with advanced fibrosis.An open-label, multicentre, single arm trial. 251 patients were included and treated with TCM consisted of FZHY tablets 1.6 g and granules, three times a day in addition to entecavir 0.5 mg daily for an additional 48 weeks. Primary outcome was regression of fibrosis (the proportion of patients with a 1-point decrease in the Ishak liver fibrosis score from baseline to week 48).Fibrosis regression occurred in 94 of 184 patients with paired liver biopsy (51.09%, 95% CI: 43.9～58.0). In 132 compensated cirrhosis patients (Ishak score ≥5), 56.06% (74/132, 95% CI: 47.5～64.2) showed fibrosis regression and reached the goal of 54% (15% more than entecavir mono-therapy). 10 patients occurred adverse reaction, most of them were mild, and all recovered or achieved remission.The combination therapy of FZHY, TCM granules and ETV could regress the liver fibrosis in the patients with HBV cirrhosis, who experienced 2 years of ETV treatment, and it is safe and well tolerated.

In this paper, submicro-scaled YF3 particles with uniform rice-like morphologies were facilely synthesized by reacting yttrium nitrate with tetrabutylammonium fluoride via a solid-state reaction process at 50 °C for 12 h. The phase confirmation and morphology of the as-prepared YF3 particles were investigated by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). SEM results reveal that the YF3 submicroparticles are about 700 nm in length and 260 nm in width. Eu3+ and Tb3+ doped YF3 submicroparticles were also prepared with similar process and their photoluminescence properties were studied. Results demonstrate that the doping of Eu3+ and Tb3+ has slight effect on the morphologies of the product. Owing to the small average crystallite size or the low crystallinity of the product, the photoluminescence intensity of the Eu3+ and Tb3+ doped YF3 submicroparticles is very weak. Some characteristic peaks even cannot be observed in the emission spectrum.

Uniform europium-based infinite coordination polymer (ICP) submicrospheres have been prepared via a facile and fast microwave heating method in 5 min, with pyridine-2, 5-dicarboxylic acid and europium nitrate as reagents and N, N-dimethylformamide (DMF) as solvent. The products were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared spectroscopy (FTIR). Thermogravimetric (TG) and derivative thermogravimetric analysis (DTG) were also carried out. XRD results reveal that the product is amorphous. SEM and TEM results show that the submicrospheres are with diameters of 200–400 nm. Furthermore, the surface of the microspheres is smooth and the submicrospheres are solid. Strong red emission centering at 618 nm was observed in the europium-based ICP microspheres on excitation with 394 nm UV light. This method may be employed to the preparation of other coordination polymers micro/nanostructures.

A fabrication of uniform apple-like LaCO3OH hierarchical nanostructures was achieved by a facile hydrothermal route using gelatin as the reactant and structure-directing agent. The hierarchical nanostructures with diameters of 2–5 μm are built from numerous nanoplatelets with thicknesses of 10–20 nm and lengths of 30–80 nm. Influential factors such as reaction time, reaction temperature, dosage of gelatin and potassium hydroxide were systematically investigated. A dipole-field-driven process was suggested for the formation of the apple-like LaCO3OH hierarchical nanostructures. Strong emission centring at 432 nm was realized in the apple-like LaCO3OH hierarchical nanostructures on excitation with 365 nm ultraviolet light. It turns out that it is easy to tune the luminescent characteristics of the LaCO3OH hierarchical nanostructures in a wide spectral range by simply varying excitation lines or doping concentration of Eu3+ and Tb3+. Particularly, white light emission can be obtained in the Eu3+ and Tb3+ codoped LaCO3OH hierarchical nanostructures on excitation in a wide ultraviolet band.