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5. Interactions of antimicrobial agents and antineoplastic agents.

Author

Yamashiro, Yoshiko, Fukuoka, Yoshikazu, Yotsuji, Akira, Yasuda, Takashi, Saikawa, Isamu, and Ueda, Yasushi

Abstract

The in-vitro interactions of four antimicrobial agents (piperacillin, dibekacin, minocycline, norfloxacin) and four antineoplastic agents (mitomycin C, bleomycin, doxorubicin, 5-fluorouracil) were examined by the chequerboard dilution method using 108 clinical isolates of four species of Gram-negative bacilli. Among the antimicrobial agents, piperacillin showed the greatest degree of synergism and norfloxacin the least. The frequency of synergism was essentially similar among the antineoplastic agents, although 5-fluorouracil was more frequently synergistic than other antineoplastic agents against . Among the four species, synergism was most frequently shown against and least against . Antagonism was rarely seen. [ABSTRACT FROM PUBLISHER] more...

Published
1986