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382 results on '"Yonemoto, Koji"'

1. Augmented use of L-asparaginase markedly improves AYA ALL outcomes: FBMTG prospective MRD2014 study

Author

Nagafuji, Koji, Miyamoto, Toshihiro, Eto, Tetsuya, Kamimura, Tomohiko, Kato, Koji, Miyazaki, Yasuhiko, Wake, Atsushi, Kohno, Kentaro, Takase, Ken, Imamura, Yutaka, Uchida, Naoyuki, Tanimoto, Kazuki, Kawano, Noriaki, Kurokawa, Toshiro, Kondo, Yukio, Ito, Yoshikiyo, Fujisaki, Tomoaki, Tsukada, Junichi, Yonemoto, Koji, Hori, Toshinori, and Akashi, Koichi

Published
2024
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2. CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

Author

Ninomiya, Toshiharu, Hata, Jun, Shibata, Mao, Honda, Takanori, Ohara, Tomoyuki, Akiyama, Masato, Nakaji, Shigeyuki, Murashita, Koichi, Mikami, Tatsuya, Jung, Songee, Misawa, Mina, Maeda, Tetsuya, Ishizuka, Naoki, Akasaka, Hiroshi, Terayama, Yasuo, Yonezawa, Hisashi, Takahashi, Junko, Ono, Kenjiro, Noguchi-Shinohara, Moeko, Komatsu, Junji, Shibata, Shutaro, Yuki-Nozaki, Sohshi, Mimura, Masaru, Bun, Shogyoku, Niimura, Hidehito, Shikimoto, Ryo, Kida, Hisashi, Nakashima, Kenji, Fukada, Yasuyo, Kowa, Hisanori, Nakano, Toshiya, Wada, Kenji, Kishi, Masafumi, Ozaki, Tomoki, Tachibana, Ayumi, Yoshino, Yuta, Shu-ichi Ueno, Jun-ichi Iga, Takebayashi, Minoru, Ishikawa, Tomohisa, Yuki, Seiji, Koyama, Asuka, Kajitani, Naoto, Hashimoto, Mamoru, Ikeda, Manabu, Kokubo, Yoshihiro, Uchida, Kazuhiro, Esaki, Midori, Taki, Yasuyuki, Tatewaki, Yasuko, Thyreau, Benjamin, Yonemoto, Koji, Yoshida, Hisako, Muto, Kaori, Inoue, Yusuke, Ri, Izen, Momozawa, Yukihide, Terao, Chikashi, Kubo, Michiaki, Kiyohara, Yutaka, Maki, Kenji, Hirabayashi, Naoki, Sakata, Satoko, Furuta, Yoshihiko, Yamasaki, Keisuke, Kitazono, Takanari, and Iga, Jun-ichi

Published
2023
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5. Relationship between quantitative physical activity and deterioration of locomotive function: a cross-sectional study using baseline data from a cohort.

Author

Tanabe, Hideki, Akai, Masami, Hayashi, Kunihiko, and Yonemoto, Koji

Subjects
PHYSICAL activity, SEDENTARY behavior, METABOLIC equivalent, LOCOMOTIVES, CROSS-sectional method
Abstract

Background: In aged society, health policies aimed at extending healthy life expectancy are critical. Maintaining physical activity is essential to prevent the deterioration of body functions. Therefore, it is important to understand the physical activity levels of the target age group and to know the content and intensity of the required physical activity quantitatively. Especially we focused the role of non-exercise activity thermogenesis and sedentary time, which are emphasized more than the introduction of exercise in cases of obesity or diabetes. Methods: A total of 193 patients from 25 institutions were included. Participants underwent a locomotive syndrome risk test (stand-up test, 2-step test, and Geriatric Locomotive Function Scale-25 questionnaire) and were classified into three stages. Physical activity was quantitatively monitored for one week with 3-axial accelerometer. Physical activity was classified into three categories; (1) Sedentary behavior (0 ∼ ≤ 1.5 metabolic equivalents (METs)), (2) Light physical activity (LPA:1.6 ∼ 2.9 METs), and (3) Moderate to vigorous physical activity (MVPA: ≥3 METs). We investigated the relationship between physical activity, including the number of steps, and the stages after gender- and age- adjustment. We also investigated the relationship between social isolation using Lubben's Social Network Scale (LSNS), as social isolation would lead to fewer opportunities to go out and less outdoor walking. Results: Comparison among the three stages showed significant difference for age (p = 0.007) and Body Mass Index (p < 0.001). After gender-and age-adjustment, there was a significant relation with a decrease in the number of steps (p = 0.002) and with MVPA. However, no relation was observed in sedentary time and LPA. LSNS did not show any statistically significant difference. Moderate to high-intensity physical activity and the number of steps is required for musculoskeletal disorders. The walking, not sedentary time, was associated to the locomotive stages, and this finding indicated the importance of lower extremity exercise. Conclusions: Adjusting for age and gender, the number of steps and moderate to vigorous activity levels were necessary to prevent worsening, and there was no effect of sedentary behavior. Merely reducing sedentary time may be inadequate for locomotive disorders. It is necessary to engage in work or exercise that moves lower extremities more actively. [ABSTRACT FROM AUTHOR]

Published
2024
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9. CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

Author

Maki, Kenji, primary, Ohara, Tomoyuki, additional, Hata, Jun, additional, Shibata, Mao, additional, Hirabayashi, Naoki, additional, Honda, Takanori, additional, Sakata, Satoko, additional, Furuta, Yoshihiko, additional, Akiyama, Masato, additional, Yamasaki, Keisuke, additional, Tatewaki, Yasuko, additional, Taki, Yasuyuki, additional, Kitazono, Takanari, additional, Mikami, Tatsuya, additional, Maeda, Tetsuya, additional, Ono, Kenjiro, additional, Mimura, Masaru, additional, Nakashima, Kenji, additional, Iga, Jun-ichi, additional, Takebayashi, Minoru, additional, Ninomiya, Toshiharu, additional, Nakaji, Shigeyuki, additional, Murashita, Koichi, additional, Jung, Songee, additional, Misawa, Mina, additional, Ishizuka, Naoki, additional, Akasaka, Hiroshi, additional, Terayama, Yasuo, additional, Yonezawa, Hisashi, additional, Takahashi, Junko, additional, Noguchi-Shinohara, Moeko, additional, Komatsu, Junji, additional, Shibata, Shutaro, additional, Yuki-Nozaki, Sohshi, additional, Bun, Shogyoku, additional, Niimura, Hidehito, additional, Shikimoto, Ryo, additional, Kida, Hisashi, additional, Fukada, Yasuyo, additional, Kowa, Hisanori, additional, Nakano, Toshiya, additional, Wada, Kenji, additional, Kishi, Masafumi, additional, Ozaki, Tomoki, additional, Tachibana, Ayumi, additional, Yoshino, Yuta, additional, Shu-ichi Ueno, Jun-ichi Iga, additional, Ishikawa, Tomohisa, additional, Yuki, Seiji, additional, Koyama, Asuka, additional, Kajitani, Naoto, additional, Hashimoto, Mamoru, additional, Ikeda, Manabu, additional, Kokubo, Yoshihiro, additional, Uchida, Kazuhiro, additional, Esaki, Midori, additional, Thyreau, Benjamin, additional, Yonemoto, Koji, additional, Yoshida, Hisako, additional, Muto, Kaori, additional, Inoue, Yusuke, additional, Ri, Izen, additional, Momozawa, Yukihide, additional, Terao, Chikashi, additional, Kubo, Michiaki, additional, and Kiyohara, Yutaka, additional

Published
2023
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11. Autoimmune hepatitis in Japan: trends in a nationwide survey

Author

Takahashi, Atsushi, Arinaga-Hino, Teruko, Ohira, Hiromasa, Torimura, Takuji, Zeniya, Mikio, Abe, Masanori, Yoshizawa, Kaname, Takaki, Akinobu, Suzuki, Yoshiyuki, Kang, Jong-Hon, Nakamoto, Nobuhiro, Fujisawa, Tomoo, Yonemoto, Koji, Tanaka, Atsushi, Takikawa, Hajime, and Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan

Published
2017
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19. Generalization of a clinical diagnosis support tool for lumbar spinal stenosis: Can the ankle brachial pressure index be replaced by palpation of the posterior tibial artery in the lumbar spinal stenosis diagnostic support tool? (DISTO project)

Author

Nikaido, Takuya, primary, Sekiguchi, Miho, additional, Yonemoto, Koji, additional, Kakuma, Tatsuyuki, additional, Watanabe, Kazuyuki, additional, Kato, Kinshi, additional, Kobayashi, Hiroshi, additional, Tominaga, Ryoji, additional, Otani, Koji, additional, Yabuki, Shoji, additional, Kikuchi, Shin-ichi, additional, and Konno, Shin-ichi, additional

Published
2022
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20. Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke A Randomized Clinical Trial and Meta-analysis

Author

Kitagawa Kazuo, Yamamoto Yasumasa, Arima Hisatomi, Maeda Toshiki, Sunami Norio, Kanzawa Takao, Eguchi Kazuo, Kamiyama Kenji, Minematsu Kazuo, Ueda Shinichiro, Rakugi Hiromi, Ohya Yusuke, Kohro Takahide, Yonemoto Koji, Okada Yasushi, Higaki Jitsuo, Tanahashi Norio, Kimura Genjiro, Umemura Satoshi, Matsumoto Masayasu, Shimamoto Kazuaki, Ito Sadayoshi, Saruta Takao, Shimada Kazuyuki, Kario Kazuomi, Saito Yoshihiko, Terayama Yasuo, Toyoda Kazunori, Okura Takafumi, Hoshino Haruhiko, Makino Hirofumi, Uchida Haruhito, Uchiyama Shinichiro, Etani Hideki, Kohriyama Tatsuo, Tomimoto Hidekazu, Yoshio Taku, Kobayashi , Shotai, Usami Hiroko, Iihoshi Satoshi, Mikami Takeshi, Mikuni Nobuhiro, Miyata Kei, Murakami Tomohiro, Endo Hideki, Fukui Takahito, Fumoto Kentaro, Hara Keiji, Honjo Kaori, Kinoshita Yusuke, Maeda Masana, Mikamoto Masaaki, Mori Daisuke, Murahashi Takeo, Nomura Ryota, Noro Shusaku, Ogino Tatsuya, Okuma Masahiro, Otake Yasuhumi, Shindo Koichiro, Sugio Hironori, Takada Hidekazu, Takahira Kazuki, Takeuchi Akiko, Watanabe Toshiichi, Yamaguchi Yohei, Abumiya Takeo, Houkin Kiyohiro, Matsumura Shigeki, Shinohe Rikiya, Kuroshima Kiyomi, Takizawa Katsumi, Yoshida Kazuto, Morimoto Hideo, Hasebe Naoyuki, Koyama Satoshi, Maruyama Junichi, Irie Shinsuke, Nakano Takahiro, Ogasawara Yukari, Ohkuma Hiroki, Shibanai Kazuo, Hikichi Kentaro, Kobayashi Shinya, Moroi Junta, Nakase Taizen, Okada Takeshi, Takano Daiki, Takenaka Shunsuke, Yoshioka Shotaro, Yanagisawa Toshiharu, Hirata Yutaka, Konno Shu, Sato Tomohiko, Ito Miiko, Kondo Rei, Mori Wataru, Saito Shinjiro, Kokubo Yasuaki, Kato Hideaki, Oyama Hideki, Matsuo Kaneyuki, Matsumoto Masahiro, Nakamura Mari, Koizumi Takayuki, Sato Hiroyuki, Shibata Yasushi, Hashimoto Masaaki, Kurita Hideharu, Matsumoto Eiji, Ishiguro Koji, Asakura Ken, Fujimaki Hiroya, Wakabayashi Kazuki, Akaji Kazunori, Horikoshi Tomo, Kano Tadashige, Katano Takehiro, Kimura Hiroaki, Mihara Ban, Suzuki Kentaro, Takayama Yohei, Ishii Akira, Momomura Sin-ichi, Sugawara Hitoshi, Yamashita Takeshi, Kaneko Uichi, Takahashi Toshie, Arai Toshinari, Tanaka Yoshihiro, Inokuma Shigehisa, Kato Yuji, Ishige Naoki, Muramatsu Kazuhiro, Nogawa Shigeru, Yoshizaki Takahito, Ohashi Takashi, Suda Sumio, Iguchi Yasuyuki, Mitsumura Hidetaka, Adachi Tomohide, Konoeda Fumie, Oki Koichi, Tanaka Ryota, Urabe Takao, Yamashiro Kazuo, Ito Akihiro, Nakatomi Hirofumi, Shojima Masaaki, Otsuka Kuniaki, Shibata Koichi, Abe Takato, Itoh Yoshiaki, Suzuki Norihiro, Toi Sono, Teramoto Tamio, Fukunaga Atsushi, Kujuro Yuki, Ohta Kouichi, Osada Takashi, Shimizu Katuyoshi, Kitagawa Yasuhisa, Tokuoka Kentaro, Omura Masao, Kikyo Hideyuki, Kamide Tomoya, Kitamura Yoshihisa, Miyashita Katsuyoshi, Mori Kentaro, Shima Hiroshi, Tamase Akira, Akutsu Tsugio, Nishiyama Kazutoshi, Takizawa Shunya, Uesugi Tsuyoshi, Ikeda Uichi, Koshikawa Megumi, Yamasaki Saeko, Inoue Atsushi, Matsumoto Yasuko, Yamaguchi Kazuyoshi, Hirose Genjirou, Kontani Satoshi, Takasawa Kazuya, Hirahara Katsumi, Kodama Makoto, Yagihara Nobue, Hata Takashi, Hori Makoto, Oda Rokuhei, Kubo Ayuka, Okuda Satoshi, Yamada Kentaro, Takeuchi Hiroki, Araki Yoshio, Ito Mizuki, Senda Joe, Wakabayashi Toshihiko, Ito Shinji, Mutoh Tatsuro, Kawase Yukinori, Ando Fumio, Okamoto Shinya, Shimada Takuya, Shindo Akihiro, Nishikawa Masakatsu, Niwa Atsushi, Sasaki Ryogen, Murata Hiroto, Yata Kenichiro, Matsuo Koushun, Yagi Hideo, Shiogai Toshiyuki, Nagakane Yoshinari, Fujinami Jun, Nakagawa Masanori, Ohara Ryo, Tomii Yasuhiro, Arakawa Yoshiki, Funaki Takeshi, Ihara Masafumi, Kitamura Akihiro, Maki Takakuni, Miyamoto Susumu, Nakaya Yoshifumi, Takahashi Ryosuke, Takenobu Yohei, Yoshida Kazumichi, Ino Tadashi, Murase Nagako, Ohotani Ryo, Kawashima Atsushi, Watanabe Akiko, Hayashi Yuko, Ohmichi Takuma, Yasuda Rei, Yoshioka Akira, Yuki Natsuko, Makino Masahiro, Yamaguchi Tatsuyuki, Matsuzaki Jyo, Niki Hitoshi, Shiraishi Shoichi, Yanagihara Takehiko, Yamada Keiichi, Hatate Jun, Miwa Kaori, Okazaki Shuhei, Arihiro Shoji, Doijiri Ryosuke, Higashida Kyoko, Kajimoto Katsufumi, Miyashita Kotaro, Nagatsuka Kazuyuki, Saito Kozue, Sugiura Yuri, Takizawa Hotake, Torii Takako, Yokota Chiaki, Kajimoto Yoshinaga, Kuroiwa Toshihiko, Fukunaga Ryuzo, Takahashi Tsutomu, Nakao Kazutami, Kajiyama Yuta, Kimura Yasuyoshi, Naka Takashi, Otomune Hironori, Tanahashi Takao, Uehara Takuya, Hashimoto Hiroyuki, Uematsu Toshihiko, Kataoka Kazuo, Okayama Satoshi, Somekawa Satoshi, Yamada Shuichi, Sasaki Rie, Yamano Shigeru, Nakao Naoyuki, Obayashi Shinji, Hamaguchi Hirotoshi, Toda Tatsushi, Washida Kazuo, Hoshi Taku, Kono Tomoyuki, Sekiya Hiroaki, Sugo Norifumi, Todo Kenichi, Togo Masaya, Yamagami Hiroshi, Yamamoto Shiro, Shiro Yoshihiko, Takaoka Toshio, Abe Satoshi, Hamada Chizuko, Ishihara Masaki, Kadota Katuhiko, Nakagawa Tomonori, Oguro Hiroaki, Takayoshi Hiroyuki, Yamaguchi Takuya, Yamaguchi , Shuuhei, Mizuhara Ryo, Okada Kazunori, Yamagata Shingo, Sasaki Akira, Abe Koji, Deguchi Kentaro, Deguchi Shoko, Nakano Yumiko, Hirai Satoshi, Uno Masaaki, Yokosuka Kimihiko, Manabe Yasuhiro, Ito Hijiri, Aoki Shiro, Hosomi Naohisa, Kihara Yasuki, Kisaka Tomohiko, Maruyama Hirofumi, Araki Hayato, Ogami Ryo, Torii Tsuyoshi, Yokoyama Noboru, Yokoyama Takakazu, Kataoka Satoshi, Kitamura Takeshi, Kanda Takashi, Maeda Toshihiko, Shimizu Fumitaka, Seki Kozaburo, Bando Yuko, Ohara Masaki, Yamasaki Masahiro, Masahira Noritaka, Ueba Tetsuya, Ueba Yusuke, Fujimoto Yuichi, Haro Keiko, Ogata Hidenori, Shida Norihiko, Matsumoto Takeshi, Okamoto Kensho, Kawamoto Ryuichi, Arakawa Shuji, Shii Hirofumi, Kanai Hidetoshi, Fujimoto Shigeru, Jinnouchi Juro, Matsuki Takayuki, Osaki Masato, Arakawa Kimika, Ibaraki Ai, Kiyohara Kanako, Ohta Yuko, Oniki Hideyuki, Sakaki Minako, Tominaga Mitsuhiro, Tsuchihashi Takuya, Higashi Saho, Ishikawa Hiromi, Ishitsuka Koji, Kitayama Jiro, Nakane Hiroshi, Yoshimura Takeo, Kakino Shunsuke, Kaneko Yoshirou, Inoue Junnosuke, Maruyama Yoshikazu, Isa Katsunori, Sakima Hirokuni, and Nakada Seigo

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Standard treatment, Population, medicine.disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Blood pressure, Randomized controlled trial, law, Relative risk, Internal medicine, Multicenter trial, Number needed to treat, Medicine, 030212 general & internal medicine, Neurology (clinical), business, education, Stroke, 030217 neurology & neurosurgery, Original Investigation
Abstract

Importance The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. Objective To assess whether intensive BP control would achieve fewer recurrent strokes vs standard BP control. Design, Setting, and Participants Randomized clinical trial (RCT) of standard vs intensive BP control in an intent-to-treat population of patients who had a history of stroke. Patients were enrolled between October 20, 2010, and December 7, 2016. For an updated meta-analysis, PubMed and the Cochrane Central Library database were searched through September 30, 2018, using the Medical Subject Headings and relevant search terms forcerebrovascular diseaseand forintensive BP lowering. This was a multicenter trial that included 140 hospitals in Japan; 1514 patients who had a history of stroke within the previous 3 years were approached, but 234 refused to give informed consent. Interventions In total, 1280 patients were randomized 1:1 to BP control to less than 140/90 mm Hg (standard treatment) (n = 640) or to less than 120/80 mm Hg (intensive treatment) (n = 640). However, 17 patients never received intervention; therefore, 1263 patients assigned to standard treatment (n = 630) or intensive treatment (n = 633) were analyzed. Main Outcomes and Measures The primary outcome was stroke recurrence. Results The trial was stopped early. Among 1263 analyzed patients (mean [SD] age, 67.2 [8.8] years; 69.4% male), 1257 of 1263 (99.5%) completed a mean (SD) of 3.9 (1.5) years of follow-up. The mean BP at baseline was 145.4/83.6 mm Hg. Throughout the overall follow-up period, the mean BP was 133.2/77.7 (95% CI, 132.5-133.8/77.1-78.4) mm Hg in the standard group and 126.7/77.4 (95% CI, 125.9-127.2/73.8-75.0) mm Hg in the intensive group. Ninety-one first recurrent strokes occurred. Nonsignificant rate reductions were seen for recurrent stroke in the intensive group compared with the standard group (hazard ratio [HR], 0.73; 95% CI, 0.49-1.11;P = .15). When this finding was pooled in 3 previous relevant RCTs in a meta-analysis, the risk ratio favored intensive BP control (relative risk, 0.78; 95% CI, 0.64-0.96;P = .02; absolute risk difference, −1.5%; 95% CI, −2.6% to −0.4%; number needed to treat, 67; 95% CI, 39-250). Conclusions and Relevance Intensive BP lowering tended to reduce stroke recurrence. The updated meta-analysis supports a target BP less than 130/80 mm Hg in secondary stroke prevention. Trial Registration ClinicalTrials.gov identifier:NCT01198496

Published
2019

21. Longitudinal Changes of Physical Activity and Sedentary Time in the Middle-Aged and Older Japanese Population: The Hisayama Study.

Author

Yonemoto, Koji, Honda, Takanori, Kishimoto, Hiro, Yoshida, Daigo, Hata, Jun, Mukai, Naoko, Shibata, Mao, Hirakawa, Yoichiro, Ninomiya, Toshiharu, and Kumagai, Shuzo

Subjects
PHYSICAL activity, SEDENTARY behavior, PERIODIC health examinations, OBESITY, STATISTICAL correlation
Abstract

Background: The purpose of this study was to describe changes in physical activity volumes and sedentary time over 3 years in the middle-aged and older Japanese population. Methods: Study participants included 1151 Japanese community-dwelling residents aged ≥40 years in 2009 who underwent 2 sets of health examinations (2009 and 2012). Using a triaxial accelerometer, longitudinal changes in sedentary time, light physical activity volume, moderate to vigorous physical activity volume, number of steps, and total physical activity volume were evaluated according to sex, age (40–49, 50–59, 60–69, 70–79, and ≥80 y), and obese (nonobese and obese) categories. Results: Sedentary time significantly increased, and all physical activity volumes significantly decreased among all participants. Although most variables did not change significantly in the 40–49 and 50–59 year age categories, similar changes as all participants were observed across all other categories. In the correlation analyses, changes in sedentary time correlated, at most, only modestly for each change in physical activity volumes, indicating that increased physical activity volume does not always lead to decreased sedentary time, and vice versa. Conclusions: Strategies to reduce sedentary time and promote physical activity are needed in Japan, particularly for people aged ≥60 years. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Additional file 1 of Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

Author

Ninomiya, Toshiharu, Nakaji, Shigeyuki, Maeda, Tetsuya, Yamada, Masahito, Mimura, Masaru, Nakashima, Kenji, Mori, Takaaki, Takebayashi, Minoru, Ohara, Tomoyuki, Hata, Jun, Kokubo, Yoshihiro, Uchida, Kazuhiro, Taki, Yasuyuki, Kumagai, Shuzo, Yonemoto, Koji, Yoshida, Hisako, Muto, Kaori, Yukihide Momozawa, Akiyama, Masato, Kubo, Michiaki, Ikeda, Manabu, Kanba, Shigenobu, and Kiyohara, Yutaka

Abstract

Additional file 1: Table S1. Instruments to measure blood pressure, electrocardiogram, and handgrip strength. Table S2. Measurement methods by item. Table S3. The baseline characteristics for 5,257 subjects at three research sites (Nakajima Town, Nakayama Town, and Hisayama Town). Table S4. Age-specific prevalence of dementia at baseline among 5,257 subjects at three research sites (Nakajima Town, Nakayama Town, and Hisayama Towna); participation rate: 85%), where surveys by home visit or visits to nursing homes or other facilities (e.g., long-stay hospitals) were conducted in addition to the surveys at the health centres or hospital. Figure S1. Organization of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).

Published
2020
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28. Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia

Author

Yamauchi, Momoko, Kinjo, Takeshi, Parrott, Gretchen, Miyagi, Kazuya, Haranaga, Shusaku, Nakayama, Yuko, Chibana, Kenji, Fujita, Kaori, Nakamoto, Atsushi, Higa, Futoshi, Owan, Isoko, Yonemoto, Koji, Fujita, Jiro, Yamauchi, Momoko, Kinjo, Takeshi, Parrott, Gretchen, Miyagi, Kazuya, Haranaga, Shusaku, Nakayama, Yuko, Chibana, Kenji, Fujita, Kaori, Nakamoto, Atsushi, Higa, Futoshi, Owan, Isoko, Yonemoto, Koji, and Fujita, Jiro

Abstract

Serum markers that differentiate between tuberculous and non-tuberculous pneumonia would be clinically useful. However, few serum markers have been investigated for their association with either disease. In this study, serum levels of interferon gamma (IFN-γ), matrix metalloproteinases 1 and 9 (MMP-1 and MMP-9, respectively), and periostin were compared between 40 pulmonary tuberculosis (PTB) and 28 non-tuberculous pneumonia (non-PTB) patients. Diagnostic performance was assessed by analysis of receiver-operating characteristic (ROC) curves and classification trees. Serum IFN-γ and MMP-1 levels were significantly higher and serum MMP-9 levels significantly lower in PTB than in non- PTB patients (p < 0.001, p = 0.002, p < 0.001, respectively). No significant difference was observed in serum periostin levels between groups. ROC curve analysis could not determine the appropriate cut-off value with high sensitivity and specificity; therefore, a classification tree method was applied. This method identified patients with limited infiltration into three groups with statistical significance (p = 0.01), and those with MMP-1 levels < 0.01 ng/ mL and periostin levels ≥ 118.8 ng/mL included only non-PTB patients (95% confidence interval 0.0–41.0). Patients with extensive infiltration were also divided into three groups with statistical significance (p < 0.001), and those with MMP-9 levels < 3.009 ng/mL included only PTB patients (95% confidence interval 76.8–100.0). In conclusion, the novel classification tree developed using MMP-1, MMP-9, and periostin data distinguished PTB from non- PTB patients. Further studies are needed to validate our cut-off values and the overall clinical usefulness of these markers.

Published
2020

34. Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia

Author

Yamauchi, Momoko, primary, Kinjo, Takeshi, additional, Parrott, Gretchen, additional, Miyagi, Kazuya, additional, Haranaga, Shusaku, additional, Nakayama, Yuko, additional, Chibana, Kenji, additional, Fujita, Kaori, additional, Nakamoto, Atsushi, additional, Higa, Futoshi, additional, Owan, Isoko, additional, Yonemoto, Koji, additional, and Fujita, Jiro, additional

Published
2020
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38. Abstract 466: Consideration of an Optimal Educational Strategy for High-Quality Cardiopulmonary Resuscitation and Chest Compression Fraction in Basic Life Support Simulation Training

Author

Sekiguchi, Hiroshi, primary, Saito, Kanako, additional, Fukami, Masataka, additional, Taira, Takayuki, additional, Ouchi, Gen, additional, Tamaki, Yuichiro, additional, Fukuda, Tatsuma, additional, Hanashiro, Kazuhiko, additional, Yoshikazu, Kawazuma, additional, Yonemoto, koji, additional, Nakajima, Shigeyoshi, additional, Terada, Taizo, additional, and Kukita, Ichiro, additional

Published
2019
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39. Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke

Author

Matsushita, Tomonaga, Ashikawa, Kyota, Yonemoto, Koji, Hirakawa, Yoichiro, Hata, Jun, Amitani, Hanae, Doi, Yasufumi, Ninomiya, Toshiharu, Kitazono, Takanari, Ibayashi, Setsuro, Iida, Mitsuo, Nakamura, Yusuke, Kiyohara, Yutaka, and Kubo, Michiaki

Published
2010

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