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A series of novel (Nd1-xYbx)2AlTaO7 oxides for thermal barrier coating application were synthesized exploring multi-step solid state clotting technology, the phase composition and thermophysical performances were analyzed. Results show that with increasing Yb2O3 content, the obvious phase transformation from weberite lattice to pyrochlore structure can be found. Owning to influence of oxygen vacancy, thermal conductivity of obtained products is less than that of 8YSZ. The thermal conductivity for (Nd1-xYbx)2AlTaO7 oxides decreases gradually with increasing Yb2O3 content, and (Nd0.3Yb0.7)2AlTaO7 has the lowest value. For (Nd1-xYbx)2AlTaO7 (x = 0, 0.1, 0.3) oxides, the lattice-energy has primary influence on thermal expansion coefficient, and electro-negativity governs the thermal expansion coefficient of (Nd1-xYbx)2AlTaO7 (x = 0.5, 0.7, 0.9 and 1) oxides. Thermal expansion coefficient of obtained oxides is close to that of 8YSZ.

Newly developed (Gd1-xYbx)2AlTaO7 oxides for high-temperature heat-insulation coatings were prepared using a multi-step solid-state fritting method. The important features of synthesized oxides including phase composition, thermal conductivity and expansion performances were studied. It is investigated that the fabricated ceramics are confirmed to possess a sole pyrochlore crystal structure. Owing to the influence of the strain fields and mass fluctuations caused by Yb2O3 addition, thermal conductivities of (Gd1-xYbx)2AlTaO7 oxides are lower than that of Gd2AlTaO7 or Yb2AlTaO7, and the (Gd0.9Yb0.1)2AlTaO7 exhibits the lowest thermal expansion coefficient. Due to the synergic effects of the relatively high electro-negativity of Yb3+, decedent lattice order, and numerous oxygen vacancies, the thermal expansion coefficients increase gradually with increasing Yb2O3 content. The thermophysical performances of (Gd1-xYbx)2AlTaO7 oxides satisfy the conditions for high-temperature heat-insulation coatings.

Ca3Ln3Ce7Ta2O26.5 (Ln = Gd or Yb) oxides were synthesised using a high-temperature sintering technology at 1873 K for 10 h in air. The crystal lattice structures and thermophysical properties of these two oxides were estimated. The fabricated ceramics present an onefold pyrochlore-kind lattice. Because of the relatively higher atomic weight of Ca3Yb3Ce7Ta2O26.5 than that of Ca3Gd3Ce7Ta2O26.5, the heat-insulation ability of Ca3Yb3Ce7Ta2O26.5 is less than that of Ca3Gd3Ce7Ta2O26.5. Due to the minor electro-negativity of Yb than that of Gd, Ca3Yb3Ce7Ta2O26.5 exhibits greater thermal expansion coefficient than Ca3Gd3Ce7Ta2O26.5.

To identify candidates for thermal barrier coatings, two complicated oxides, Ca3Nd3Ce7Ta2O26.5 and Ca3Dy3Ce7Ta2O26.5, were prepared via a high-temperature sintering method. The lattice-type and thermal physical properties of these two oxides were studied. The obtained products have a single pyrochlore-type lattice. Because of the high atomic weights, complex element compositions, and complicate lattice structures, the thermal conductivities of the obtained products are lower than that of the yttria-stabilized zirconia (YSZ). The thermal conductivity of Ca3Dy3Ce7Ta2O26.5 is lower than that of Ca3Nd3Ce7Ta2O26.5. The coefficients of thermal expansion for Ca3Ln3Ce7Ta2O26.5 (Ln = Dy and Nd) oxides at 1473 K are approximately 11.92 × 10−6/K and 12.1 × 10−6/K, respectively. The thermal conductivities and expansion coefficients of these two oxides meet the demands for thermal barrier coatings.

Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response in endothelial cells. It is well accepted that endothelial dysfunction caused by inflammation is a key initiating event in atherosclerotic plaque formation, which leads to the occurrence and development of the cardiovascular adverse events in clinical since the inflammatory responses of endothelial cells could induce and enhance the deposition of extensive lipid and the formation of atherosclerotic plaque in the intima. Thus, it is essential to investigate the role and potential mechanisms in endothelial inflammatory response to prevent the formation and development of many cardiovascular diseases including atherosclerosis. So far, the recent studies have revealed that IL-37 is able to inhibit inflammatory response by suppressing the TLR2-NF-κB-ICAM-1 pathway intracellularly in human coronary artery endothelial cells (HCAECs). Further, the role of IL-37 may be related to the IL-18 pathway extracellularly and involved in the adhesion and transmigration of neutrophils in HCAECs.