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Your search keyword '"Yan, Liwen"' showing total 261 results
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261 results on '"Yan, Liwen"'

33. MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy

Author

Zhang,Qing, Hu,Wenjun, Guo,Mingxue, Zhang,Xinyu, Zhang,Qin, Peng,Fengqi, Yan,Liwen, Hu,Zucheng, Tangthianchaichana,Jakkree, Shen,Yan, Hu,Haiyan, Du,Shouying, Lu,Yang, Zhang,Qing, Hu,Wenjun, Guo,Mingxue, Zhang,Xinyu, Zhang,Qin, Peng,Fengqi, Yan,Liwen, Hu,Zucheng, Tangthianchaichana,Jakkree, Shen,Yan, Hu,Haiyan, Du,Shouying, and Lu,Yang

Abstract

Qing Zhang,1,* Wenjun Hu,1,* Mingxue Guo,1 Xinyu Zhang,1 Qin Zhang,1 Fengqi Peng,1 Liwen Yan,1 Zucheng Hu,1 Jakkree Tangthianchaichana,2 Yan Shen,3 Haiyan Hu,4 Shouying Du,1 Yang Lu1 1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People’s Republic of China; 2Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand; 3School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 4School of Pharmacy, Beijing Health Vocational College, Beijing, 101100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyan Hu, School of Pharmacy, Beijing Health Vocational College, Beijing, 101100, People’s Republic of China, Email yxyhhy@163.com Yang Lu, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People’s Republic of China, Email luyang@bucm.edu.cnIntroduction: Responsive drug delivery systems hold great promise for tumor treatment as they focus on therapeutic agents directly, thus minimizing systemic toxicities and drug leakage. In this study, we covalently bound a matrix metalloproteinases-2 (MMP-2) enzyme-sensitive peptide to a tissue-penetrating peptide to rationally design a MMP-2 responsive multifunctional peptide hydrogel platform (aP/IR@FMKB) for cancer photothermal-chemo-immunotherapy. The constructed aP/IR@FMKB with bufalin (BF) loaded in trimethyl chitosan nanoparticles (TB NPs), photothermal agent IR820, and immune checkpoint inhibitor aPD-L1 by self-assembly could be dissociated in the presence of MMP-2 enzyme, triggering content release.Methods: TB NPs, IR820, and aPD-L1 were encapsulated by intermolecular self-assembly and enzyme-sensitive nanogels (aP/IR@FMKB) were constructed. The in vitro cytotoxicity of the blank gels and their ability to induce immunogenic cell death (ICD) in aP/IR@FMKB were evaluated using 4T1 cells. The promotion of dee

Published
2024

36. Preparation and Properties of Elastic Mullite Fibrous Porous Materials with Excellent High-Temperature Resistance and Thermal Stability.

Author

Zhang, Xiang, Zhang, Xueying, Wang, Zhongyan, Xue, Yunjia, Guo, Anran, Yan, Liwen, Hou, Feng, and Liu, Jiachen

Subjects
POROUS materials, ELASTICITY, THERMAL stability, THERMAL resistance, MULLITE, THERMAL insulation
Abstract

Mullite fiber felt is a promising material that may fulfill the demands of advanced flexible external thermal insulation blankets. However, research on the fabrication and performance of mullite fiber felt with high-temperature resistance and thermal stability is still lacking. In this work, mullite fibers were selected as raw materials for the fabrication of mullite fibrous porous materials with a three-dimensional net structure. Said materials' high-temperature resistance and thermal stability were investigated by assessing the effects of various heat treatment temperatures (1100 °C, 1300 °C, and 1500 °C) on the phase composition, microstructure, and performance of their products. When the heat treatment temperature was below 1300 °C, both the phase compositions and microstructures of products exhibited stability. The compressive rebound rate of the product before and after 1100 °C reached 92.9% and 84.5%, respectively. The backside temperature of the as-prepared products was 361.6 °C when tested at 1500 °C for 4000 s. The as-prepared mullite fibrous porous materials demonstrated excellent high-temperature resistance, thermal stability, thermal insulation performance, and compressive rebound capacity, thereby indicating the great potential of the as-prepared mullite fibrous porous materials in the form of mullite fiber felt within advanced flexible external thermal insulation blankets. [ABSTRACT FROM AUTHOR]

Published
2024
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37. High-Emissivity Double-Layer ZrB 2 -Modified Coating on Flexible Aluminum Silicate Fiber Fabric with Enhanced Oxidation Resistance and Tensile Strength.

Author

Li, Wei, Zhang, Xueying, Yan, Liwen, Guo, Anran, Du, Haiyan, and Liu, Jiachen

Subjects
SILICATE fibers, ALUMINUM silicates, TENSILE strength, THERMAL insulation, GLASS coatings, SURFACE coatings
Abstract

Fibers crystallize and become brittle at high temperatures for a long time, so the surface coating must maintain long-lasting emission performance, which requires superior antioxidant properties of the high-emissivity fillers. To improve the radiation performance of the coating and the tensile strength of the fiber fabric, a double-layer coating with high emissivity was prepared on the surface of flexible aluminum silicate fiber fabric (ASFF) using MoSi2 and SiC as emissive agents. The incorporation of borosilicate glass into the outer coating during high-temperature oxidation of ZrB2 results in superior encapsulation of emitter particles, effectively filling the pores of the coating and significantly reducing the oxidation rate of MoSi2 and SiC. Furthermore, the addition of an intermediate ZrO2 layer enhances the fiber bundle's toughness. The obtained double-coated ASFF exhibits an exceptionally high tensile strength of 57.6 MPa and a high bond strength of 156.2 kPa. After being subjected to a 3 h heating process, the emissivity exhibits a minimal decrease of only 0.032, while still maintaining a high value above 0.9. The thermal insulation composites, consisting of a flexible ASFF matrix and a ZrB2-modified double-layer coating, exhibit significant potential for broad applications in the field of thermal protection. [ABSTRACT FROM AUTHOR]

Published
2024
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