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Your search keyword '"Xie, Guo-Jun"' showing total 363 results
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363 results on '"Xie, Guo-Jun"'

46. Intranasal Administration of Brain-Derived Neurotrophic Factor Rescues Depressive-Like Phenotypes in Chronic Unpredictable Mild Stress Mice

Author

Li,Xiao-Ling, Liu,Hua, Liu,Shu-Han, Cheng,Yong, Xie,Guo-Jun, Li,Xiao-Ling, Liu,Hua, Liu,Shu-Han, Cheng,Yong, and Xie,Guo-Jun

Abstract

Xiao-Ling Li,1,* Hua Liu,2,* Shu-Han Liu,2 Yong Cheng,2,3 Guo-Jun Xie1 1The Third People’s Hospital of Foshan, Foshan, People’s Republic of China; 2Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, People’s Republic of China; 3Institute of National Security, Minzu University of China, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Cheng, Minzu Unviersity of China, 27 South Zhongguancun Avenue, Beijing, 100081, People’s Republic of China, Email yongcheng@muc.edu.cn Guo-Jun Xie, The Third People’s Hospital of Foshan, 102 South Jinlan Road, Foshan, 528041, People’s Republic of China, Email xiegjfs@163.comIntroduction: Major depression disorder is the most common diagnosed mental illnesses, and it bring a high social and economic burden. However, the current treatment for depression has limitations with side effects. Hence, there is an urgent need to search more effective treatment for major depressive disorder. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival, growth, and maintenance of neurons.Methods: We administered BDNF into chronic unpredictable mild stress (CUMS)-induced depression mice and assessed the effects of intranasal delivery of BDNF in depression by the tail suspension test, forced swimming test, novelty suppressed feeding test, and open-field test.Results: We find that the intranasal administration of BDNF reversed the depressive-like behaviors in CUMS mice as measured Further analyses suggested that BDNF treatment reduced pro-inflammatory cytokine (IL-6, TNF-α, iNOS and IL-1β) expressions in the hippocampus of CUMS mice. In addition, our results showed that BDNF markedly reduced oxidative stress in the hippocampus and blood of CUMS mice. Moreover, our data suggested that BDNF treatment increased neurogenesis in the hippocampus of CUMS mice.Discussion: Taken together, our resu

Published
2022

47. Design of mine-used transmission substation with gateway functio

Author

WANG Shu-feng, XIE Guo-jun, and FANG Bi

Subjects
coal mine monitoring, gateway, transmission substation, intrinsic safety substation, data acquisition, signal isolatio, Mining engineering. Metallurgy, TN1-997
Abstract

In view of problems of single implementation agreement and communication interface existed in traditional mine-used transmission substation, a mine-used intrinsic safety transmission substation with gateway function was designed, hardware design and software design of the substation were introduced in details. The transmission substation uses distributed structure and multi-communication interface, which has functions of data acquisition, data fusion and data transmission. The communication interface can freely define agreement type, edit data address, share data gateway. The test results show that the substation has both gateway and substation function, realizes seamless compatibility and loose coupling of multi-equipment at monitored site with high practical value.

Published
2013

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