6,262 results on '"Xia, W."'
Search Results
2. Pressure-induced double-dome superconductivity in kagome metal CsTi3Bi5
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Nie, J. Y., Yang, X. F., Zhang, X., Liu, X. Q., Xia, W., Dai, D. Z., Zhao, C. C., Tu, C. P., Kong, X. M., Jin, X. B., Guo, Y. F., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
We present high-pressure resistance measurements up to 40 GPa on recently discovered titanium-based kagome metal CsTi$_3$Bi$_5$. At ambient pressure, CsTi$_3$Bi$_5$ shows no evidence of superconductivity in resistivity and specific heat. By applying pressure, superconductivity emerges and the superconducting transition temperature ${\it T}_{\rm c}$ reaches its first maximum of 1.2 K at $\sim$5 GPa. Then the ${\it T}_{\rm c}$ is suppressed by pressure and cannot be detected around 10 GPa, manifesting as a superconducting dome. Remarkably, upon further increasing pressure above $\sim$13 GPa, another superconducting dome shows up, with the maximum ${\it T}_{\rm c}$ of 0.6 K and ending pressure at $\sim$36 GPa. The variation of ${\it T}_{\rm c}$ displays a clear double-dome shape in the superconducting phase diagram. Our work demonstrates the similarity between CsTi$_3$Bi$_5$ and CsV$_3$Sb$_5$, providing valuable insights into the rich physics of these novel kagome metals., Comment: 7 pages, 5 figures
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- 2023
3. Characterization of the Pathogen Distribution and Drug Resistance in Bloodstream Infections During COVID-19 Pandemic in a Tertiary Hospital in Eastern China: Comparison with the Pre-Pandemic Period
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Gu M, Zhang X, Ni F, Wang J, Xia W, and Lu Y
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covid-19 pandemic ,bloodstream infection ,pathogen distribution ,antibiotic resistance ,Infectious and parasitic diseases ,RC109-216 - Abstract
Min Gu,1,2,* Xiaohui Zhang,1,2,* Fang Ni,1,2 Jue Wang,1,2 Wenying Xia,1,2 Yanfei Lu1,2 1Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of China; 2National Key Clinical Department of Laboratory Medicine, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanfei Lu; Wenying Xia, Department of Laboratory Medicine, Jiangsu Province Hospital, Street No. 300, Guangzhou, 210029, People’s Republic of China, Tel +8625-6830-6287, Email 549793546@qq.com; xiawenying21106891@163.comPurpose: To explore the characteristics of the pathogen distribution and drug resistance in bloodstream infections (BSIs) during the COVID-19 pandemic in a tertiary hospital in eastern China, and to compare them with those before the pandemic.Patients and Methods: Non-repetitive strain data of BSIs were retrospectively obtained before the COVID-19 pandemic (Pre-Pandemic, n=2698) and during the COVID-19 pandemic (Pandemic, n=2922), the distribution of pathogens and drug resistance were compared between the two groups.Results: The main pathogens of BSIs were Gram-negative bacteria (57.91%), followed by Gram-positive bacteria (32.58%), fungi and anaerobic bacteria accounting for 5.48% and 3.39%, respectively. Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus were the top 3 isolates. The proportion of Serratia marcescens, Enterobacter aerogenes, Enterococcus faecium, Enterococcus faecalis and Candida tropicalis were significantly increased, while those of Pseudomonas aeruginosa, Streptococcus sanguinis and Streptococcus pneumoniae were significantly decreased when compared to the Pre-Pandemic (P< 0.05). Carbapenem-resistant Enterobacterales (CRE) significantly elevated during the Pandemic (17.4% vs 14.4%, P=0.041); the detection of carbapenem-resistant Pseudomonas aeruginosa (CRPA) significantly ascended (39.0% vs 24.4%, P=0.016); and the proportion of carbapenem-resistant Acinetobacter baumannii (CRAB) maintained stable (78.8%). Gram-positive bacteria had the lowest resistance to linezolid, vancomycin and tigecycline, which remained a stable trend with the Pre-Pandemic (< 5.0%). The isolate rates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) were 38.9% and 1.0%, respectively. Staphylococcus aureus showed a decrease in the isolation rate of vancomycin minimum inhibitory concentration (MIC) ≤ 0.5 μg/mL (χ 2=7.676, P=0.006) and an increase with vancomycin MIC=1 μg/mL (χ 2=9.008, P=0.003).Conclusion: The pathogen distribution and drug resistance of BSIs during the COVID-19 pandemic were transformed from Pre-Pandemic and accompanied by increasing bacterial resistance. Clinical management of antibiotic application and infection control should be strengthened.Keywords: COVID-19 pandemic, bloodstream infection, pathogen distribution, antibiotic resistance
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- 2024
4. Deteriorated bone microarchitecture caused by sympathetic overstimulation in pheochromocytoma and paraganglioma
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Qi, W., Cui, L., Jiajue, R., Pang, Q., Chi, Y., Liu, W., Jiang, Y., Wang, O., Li, M., Xing, X., Tong, A., and Xia, W.
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- 2024
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5. Efficacy and Safety of Re-Challenging PD-1 Inhibitors in Second-Line Treatment in Metastatic Nasopharyngeal Carcinoma Previously Treated with Chemotherapy and PD-1 Inhibitors
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Bei W, Dong S, Liu G, Lin L, Jiang Y, Lu N, Li W, Liang H, Xiang Y, and Xia W
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metastatic nasopharyngeal carcinoma ,chemotherapy ,pd-1 immune checkpoint inhibitors ,second-line treatment strategies ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Weixin Bei,1,2,* Shuhui Dong,1,2,* Guoying Liu,1,3,4,* Lanfeng Lin,2,5,* Yaofei Jiang,1,2 Nian Lu,1,2 Wangzhong Li,1,2 Hu Liang,1,2 Yanqun Xiang,1,2 Weixiong Xia1,2 1Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 4Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 5Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanqun Xiang; Weixiong Xia, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People’s Republic of China, Tel +86-20-87343643, Fax +86-20-87343392, Email xiangyq@sysucc.org.cn; xiawx@sysucc.org.cnBackground: We aim to evaluate the efficacy and safety of anti-PD1 rechallenge in combination with chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC) who have progressed on prior anti-PD1 therapy.Patients and Methods: We enrolled patients with mNPC who received chemotherapy combined with PD-1 immune-checkpoint inhibitors (ICIs) or chemotherapy alone after prior progression of anti-PD1 therapy. The primary endpoint was progress-free survival (PFS), and the secondary endpoints included overall survival (OS), disease control rate (DCR) and objective response rate (ORR).Results: A total of 96 patients were eligible between January 2015 and December 2020. Thirty-seven (38.5%) were in the PD-1 ICIs re-challenge group, while the remaining 59 patients (61.5%) were in the chemotherapy group. The ORR and DCR of PD-1 ICIs group and chemotherapy group were 37.8% vs 23.7% and 86.5% vs.74.5%, respectively. After a median follow-up period of 21.1 months (IQR 16.1– 28.7), the log-rank analysis demonstrated a significantly improved PFS in the PD-1 ICIs re-challenge group compared to the chemotherapy group (8.4 months [95% CI 4.3– 14.0] vs 5.0 months [95% CI 2.8– 7.2], P = 0.03). However, no significant difference in OS was observed between the two groups (28.3 vs 24.1 months, P = 0.09). The two groups had similar adverse reactions, but the incidence of grade 3 or 4 thrombocytopenia was significantly higher in the PD-1 ICIs re-challenge group (18.9% vs 3.4%, P = 0.025).Conclusion: mNPC patients who progressed from prior anti-PD1 therapy could benefit from the anti-PD1 rechallenge in combination with chemotherapy. However, further validation is needed.Keywords: metastatic nasopharyngeal carcinoma, chemotherapy, PD-1 immune checkpoint inhibitors, second-line treatment strategies
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- 2024
6. Knowledge, Attitude and Practice of Radiologists Regarding Artificial Intelligence in Medical Imaging
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Huang W, Li Y, Bao Z, Ye J, Xia W, Lv Y, Lu J, Wang C, and Zhu X
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artificial intelligence ,medical imaging ,knowledge ,attitude ,practice ,radiologists ,cross-sectional study ,Medicine (General) ,R5-920 - Abstract
Wennuo Huang,1,* Yuanzhe Li,2,* Zhuqing Bao,3,* Jing Ye,1 Wei Xia,1 Yan Lv,1 Jiahui Lu,4 Chao Wang,1 Xi Zhu1 1Department of Radiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, 225002, People’s Republic of China; 2Department of CT/MRI, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, 362000, People’s Republic of China; 3Department of Emergency, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, 225002, People’s Republic of China; 4School of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi Zhu, Department of Radiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, 225002, Jiangsu, People’s Republic of China, Tel +8618051062318, Email yzdxlcyxyzhuxi@qq.comPurpose: This study aimed to investigate the knowledge, attitudes, and practice (KAP) of radiologists regarding artificial intelligence (AI) in medical imaging in the southeast of China.Methods: This cross-sectional study was conducted among radiologists in the Jiangsu, Zhejiang, and Fujian regions from October to December 2022. A self-administered questionnaire was used to collect demographic data and assess the KAP of participants towards AI in medical imaging. A structural equation model (SEM) was used to analyze the relationships between KAP.Results: The study included 452 valid questionnaires. The mean knowledge score was 9.01± 4.87, the attitude score was 48.96± 4.90, and 75.22% of participants actively engaged in AI-related practices. Having a master’s degree or above (OR=1.877, P=0.024), 5– 10 years of radiology experience (OR=3.481, P=0.010), AI diagnosis-related training (OR=2.915, P< 0.001), and engaging in AI diagnosis-related research (OR=3.178, P< 0.001) were associated with sufficient knowledge. Participants with a junior college degree (OR=2.139, P=0.028), 5– 10 years of radiology experience (OR=2.462, P=0.047), and AI diagnosis-related training (OR=2.264, P< 0.001) were associated with a positive attitude. Higher knowledge scores (OR=5.240, P< 0.001), an associate senior professional title (OR=4.267, P=0.026), 5– 10 years of radiology experience (OR=0.344, P=0.044), utilizing AI diagnosis (OR=3.643, P=0.001), and engaging in AI diagnosis-related research (OR=6.382, P< 0.001) were associated with proactive practice. The SEM showed that knowledge had a direct effect on attitude (β=0.481, P< 0.001) and practice (β=0.412, P< 0.001), and attitude had a direct effect on practice (β=0.135, P< 0.001).Conclusion: Radiologists in southeastern China hold a favorable outlook on AI-assisted medical imaging, showing solid understanding and enthusiasm for its adoption, despite half lacking relevant training. There is a need for more AI diagnosis-related training, an efficient standardized AI database for medical imaging, and active promotion of AI-assisted imaging in clinical practice. Further research with larger sample sizes and more regions is necessary.Keywords: artificial intelligence, medical imaging, knowledge, attitude, practice, radiologists, cross-sectional study
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- 2024
7. Albumin-to-Globulin Ratio Combined with Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor in Multiple Myeloma with Renal Impairment
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Zhang Y, Yao X, Chen Z, Qin Z, Cai Y, Xia W, and Hu H
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multiple myeloma ,renal impairment ,neutrophil–lymphocyte ratio ,albumin-to-globulin ratio ,prognosis ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Yingzi Zhang,1 Xiajuan Yao,1 Yaoquan Zhang,1 Zhuyun Chen,1 Zhongke Qin,1 Ying Cai,2 Wenkai Xia,1 Hong Hu1 1Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, 214400, People’s Republic of China; 2Department of Hematology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, 214400, People’s Republic of ChinaCorrespondence: Wenkai Xia; Hong Hu, Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, 3 Yingrui Road, Jiangyin, Jiangsu, 214400, People’s Republic of China, Email xiawenkai.xia@gmail.com; huhong1523@163.comBackground: The albumin-to-globulin ratio (AGR) and neutrophil-to-lymphocyte ratio (NLR) have been recently regarded as promising prognostic factors in various malignancies. The present study investigated the prognostic value of combining the AGR and NLR (ANS) for risk assessments in multiple myeloma (MM) with renal impairment (RI).Methods: From 2011 to 2018, 79 patients with MM and RI were enrolled in this study. Receiver operating curves (ROCs) were constructed to determine optimal AGR and NLR thresholds for predicting overall survival (OS) and progression-free survival (PFS) during follow up. The prognostic values of AGR, NLR, and ANS were evaluated with Cox regression and Kaplan-Meier methods. We also created a predictive nomogram for prognostic evaluations of OS and PFS, and the predictive accuracy was assessed with a concordance index (c-index).Results: The ROC curves analyses showed that the optimal cut-off levels were 2.27 for NLR and 1.57 for AGR. A high NLR and a high ANS were significantly associated with worse OS and PFS. However, a high NLR combined with a low AGR was associated with worse OS. Multivariate analyses demonstrated that both the NLR and ANS were independent predictors for both OS and PFS and that a low AGR was an independent predictor of a reduced OS. The nomogram accurately predicted OS (c-index: 0.785) and PFS (c-index: 0.786) in patients with MM and RI.Conclusion: ANS may serve as a potential prognostic biomarker in patients with MM and RI. The proposed nomograms may facilitate prognostic predictions for patients with MM and RI.Keywords: multiple myeloma, renal impairment, neutrophil–lymphocyte ratio, albumin-to-globulin ratio, prognosis
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- 2024
8. miR-4443 Contained Extracellular Vesicles: A Factor for Endometriosis Progression by PI3K/AKT/ACSS2 Cascade in-vitro
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Ji S, Qi H, Yan L, Zhang D, Wang Y, MuDanLiFu H, He C, Xia W, Zhu Q, Liang Y, and Zhang J
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endometriosis ,menstrual blood ,biomarker ,extracellular vesicles ,mir-4443 ,Medicine (General) ,R5-920 - Abstract
Sifan Ji,1,2,* Hang Qi,1,2,* Li Yan,1,2,* Duo Zhang,1,2 Yang Wang,1,2 HaLiSai MuDanLiFu,1,2 Chuqing He,1,2 Wei Xia,1,2 Qian Zhu,1,2 Yan Liang,1,2 Jian Zhang1,2 1Department of Obstetrics and Gynecology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Zhang, Department of Obstetrics and Gynecology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Tel +86 18017316017, Email zhangjian_ipmch@sjtu.edu.cnIntroduction: Endometriosis (EM) is an estrogen-dependent benign gynecologic disease affecting approximately 10% of reproductive-age women with a high recurrence rate, but lacks reliable biomarkers. No previous studies have investigated the possible use of extracellular vesicle (EV)-associated micro RNAs (miRNAs) from menstrual blood (MB) as candidate diagnostic or prognostic markers of EM.Methods: Specimens were obtained from endometriosis and non-endometriosis patients at the International Peace Maternity and Child Health Hospital in Shanghai. Microarray was used to screen differentially expressed miRNAs among peritoneal fluid (PF), fallopian tube fluid (FF), and MB. Dual-luciferase reporter gene assay was carried out to verify the relationship between miR-4443 and ACSS2. Cell proliferation and Transwell invasion assays were performed in vitro after intervention on miR-4443 and ACSS2 in hEM15A human endometrial stromal cells and primary human endometrial stromal cells (hESCs). Spearman correlation analysis, receiver operating characteristic (ROC) curve analysis, and survival analysis were applied to clinical data, including severity of symptoms and relapse of EM among EM patients.Results: EV-associated miR-4443 was abundant in MB of endometriosis patients. ACSS2 knockdown and miR-4443 overexpression promoted cell proliferation and migration via the PI3K/AKT pathway. miR-4443 levels in MB-EVs were positively correlated with the degree of dyspareunia (r=0.64; P< 0.0001) and dysmenorrhea (r=0.42; P< 0.01) in the endometriosis group. ROC curve analyses showed an area under the curve (AUC) of 0.741 (95% CI 0.624– 0.858; P< 0.05) for miR-4443 and an AUC of 0.929 (95% CI 0.880– 0.978; P< 0.05) for the combination of miR-4443 and dysmenorrhea.Conclusion: MB-derived EV-associated miR-4443 might participate in endometriosis development, thus providing a new candidate biomarker for the noninvasive prediction of endometriosis recurrence. Keywords: endometriosis, menstrual blood, biomarker, extracellular vesicles, miR-4443
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- 2024
9. Significance of Pre-Treatment CALLY Score Combined with EBV-DNA Levels for Prognostication in Non-Metastatic Nasopharyngeal Cancer Patients: A Clinical Perspective
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Jiang T, Sun H, Xu T, Xue S, Xia W, Xiao X, Wang Y, Guo L, and Lin H
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cally score ,ebv dna ,nasopharyngeal carcinoma ,biomarker ,prognostic model ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Tongchao Jiang,1,* Haishuang Sun,2,* Tiankai Xu,1 Shuyu Xue,1 Wen Xia,2 Xiang Xiao,1 Ying Wang,1 Ling Guo,3 Huanxin Lin1 1Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huanxin Lin, Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email linhx@sysucc.org.cn Ling Guo, Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email guoling@sysucc.org.cnBackground: The C-reactive protein-albumin-lymphocyte (CALLY) score is a novel indicator associated with inflammation, immunity, and nutrition, utilized for cancer prognostic stratification. This study aimed to evaluate the integrated prognostic significance of the pre-treatment CALLY score and Epstein-Barr virus (EBV) DNA levels in nasopharyngeal carcinoma (NPC) patients and to develop prognostic models.Patients and Methods: A total of 1707 NPC patients from September 2015 to December 2017 were retrospectively enrolled. The cut-off point for the CALLY score, determined by maximum selected rank statistics, integrates with the published cut-off point for pre-EBV DNA to develop a comprehensive index. Subsequently, patients were randomly allocated in a 1:1 ratio into training and validation cohorts. Survival analysis was conducted using the Kaplan-Meier method with Log rank tests, and the Cox proportional hazards model was applied to identify independent prognostic factors for constructing predictive nomograms. The predictive ability of the nomograms were assessed through the concordance index (C-index), calibration curves, and decision curve analysis.Results: By integrating CALLY scores and EBV-DNA levels, patients were categorized into three risk clusters. Kaplan-Meier curves reveal significant differences in overall survival (OS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRRFS) outcomes among different risk groups (all P values < 0.05). Multivariate analysis revealed that CALLY-EBV DNA index serves as an independent prognostic factor for the OS, DMFS, and LRRFS. The prognostic nomograms based on the CALLY-EBV DNA index provided accurate predictions for 1-year, 3-year, and 5-year OS, DMFS, and LRRFS. Additionally, compared to the traditional TNM staging system, the nomograms exhibited enhanced discriminatory power, calibration capability, and clinical applicability. All results were in agreement with the validation cohort.Conclusion: The CALLY-EBV DNA index is an independent prognostic biomarker. The nomogram prediction models, constructed based on the CALLY-EBV DNA index, demonstrates superior predictive performance compared to the traditional TNM staging.Keywords: CALLY score, EBV DNA, nasopharyngeal carcinoma, biomarker, prognostic model
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- 2024
10. Multiple topological nodal structure in LaSb2 with large linear magnetoresistance
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Qiao, Y. X., Tao, Z. C., Wang, F. Y., Wang, Huaiqiang, Jiang, Z. C., Liu, Z. T., Cho, Soohyun, Zhang, F. Y., Meng, Q. K., Xia, W., Yang, Y. C., Huang, Z., Liu, J. S., Liu, Z. H., Zhu, Z. W., Qiao, S., Guo, Y. F., Zhang, Haijun, and Shen, Dawei
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
Unconventional fermions in the immensely studied topological semimetals are the source for rich exotic topological properties. Here, using symmetry analysis and first-principles calculations, we propose the coexistence of multiple topological nodal structure in LaSb2, including topological nodal surfaces, nodal lines and in particular eightfold degenerate nodal points, which have been scarcely observed in a single material. Further, utilizing high resolution angle-resolved photoemission spectroscopy in combination with Shubnikov-de Haas quantum oscillations measurements, we confirm the existence of nodal surfaces and eightfold degenerate nodal points in LaSb2, and extract the {\pi} Berry phase proving the non-trivial electronic band structure topology therein. The intriguing multiple topological nodal structure might play a crucial role in giving rise to the large linear magnetoresistance. Our work renews the insights into the exotic topological phenomena in LaSb2 and its analogous.
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- 2022
11. Correlation of lipocalin 2 and glycolipid metabolism and body composition in a large cohort of children with osteogenesis imperfecta
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Zheng, W.-b., Hu, J., Sun, L., Liu, J.-y., Zhang, Q., Wang, O., Jiang, Y., Xia, W.-b., Xing, X.-p., and Li, M.
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- 2024
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12. Genotype–phenotype relationship and comparison between eastern and western patients with osteogenesis imperfecta
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Lin, X., Hu, J., Zhou, B., Zhang, Q., Jiang, Y., Wang, O., Xia, W., Xing, X., and Li, M.
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- 2024
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13. PTH level might be associated with impaired quality of life in patients with nonsurgical hypoparathyroidism
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Song, A., Chen, S., Yang, Y., Jiang, Y., Jiang, Y., Li, M., Xia, W., Wang, O., and Xing, X.
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- 2023
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14. Expression of ICAM-1 and E-selectin in different metabolic obesity phenotypes: discrepancy for endothelial dysfunction
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Liu, M., Wang, P., Xie, P., Xu, X., He, L., Chen, X., Zhang, S., Lin, Y., Huang, Y., Xia, W., Wang, L., Liao, X., Guo, Y., and Zhuang, X.
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- 2023
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15. Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial
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Chen Y, Li WX, Wu JH, Chen GH, Yang CM, Lu H, Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Hong RX, Jiang KK, Zhong YY, Zhang G, Tienchaiananda P, Oikawa M, Yuan ZY, and Chen QJ
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adjuvant chemotherapy ,capecitabine ,sysucc-001 ,triple-negative breast cancer ,tnbc ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Ying Chen,1,2,* Wen-Xia Li,1,2,* Jia-Hua Wu,1,2 Geng-Hang Chen,2 Chun-Min Yang,1,2 Hai Lu,1,2 Xi Wang,3 Shu-Sen Wang,4 Heng Huang,5 Li Cai,6 Li Zhao,7 Rou-Jun Peng,8 Ying Lin,9 Jun Tang,3 Jian Zeng,10 Le-Hong Zhang,11 Yong-Li Ke,12 Xian-Ming Wang,13 Xin-Mei Liu,14 An-Qin Zhang,15 Fei Xu,4 Xi-Wen Bi,4 Jia-Jia Huang,4 Ji-Bin Li,16 Dan-Mei Pang,17 Cong Xue,4 Yan-Xia Shi,4 Zhen-Yu He,18 Huan-Xin Lin,18 Xin An,4 Wen Xia,4 Ye Cao,16 Ying Guo,16 Ruo-Xi Hong,4 Kui-Kui Jiang,4 Yong-Yi Zhong,4 Ge Zhang,19 Piyawan Tienchaiananda,20 Masahiro Oikawa,21 Zhong-Yu Yuan,4 Qian-Jun Chen22,23 1Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3Department of Breast Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 5Department of Breast Oncology, Lianjiang People’s Hospital, Lianjiang, People’s Republic of China; 6Department of Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, People’s Republic of China; 7Department of Breast Oncology, Guangzhou First People Hospital, Guangzhou, People’s Republic of China; 8Department of Integrated Therapy in Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 9Department of Breast Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 10Department of Breast Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 11Department of Breast Oncology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 12Department of Breast Oncology, General Hospital of PLA Guangzhou Military Area, Guangzhou, People’s Republic of China; 13Department of Breast Oncology, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of China; 14Department of Breast Oncology, Haikou People’s Hospital, Haikou, People’s Republic of China; 15Department of Breast Oncology, Maternal and Child Health Care Hospital of Guangdong Province, Guangzhou, People’s Republic of China; 16Department of Good Clinical Practice, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 17Department of Medical Oncology, Foshan First People’s Hospital, Foshan, People’s Republic of China; 18Department of Radiotherapy, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 19Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong; 20Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand; 21The Department of Breast Surgery, New-wa-kai Oikawa Hospital, Fukuoka, Japan; 22State Key Laboratory of Traditional Chinese Medicine Syndrome/Departments of Gynecologic Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 23State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian-Jun Chen, 55N, Neihuanxi Road, Guangzhou, Guangdong, 510006, People’s Republic of China, Tel +86 1868883505, Email cqj55@163.com Zhong-Yu Yuan, 651 Dongfeng Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13798027658, Email yuanzhy@sysucc.org.cnPurpose: Results from studies of extended capecitabine after the standard adjuvant chemotherapy in early stage triple-negative breast cancer (TNBC) were inconsistent, and only low-dose capecitabine from the SYSUCC-001 trial improved disease-free survival (DFS). Adjustment of the conventional adjuvant chemotherapy doses affect the prognosis and may affect the efficacy of subsequent treatments. This study investigated whether the survival benefit of the SYSUCC-001 trial was affected by dose adjustment of the standard adjuvant chemotherapy or not.Patients and Methods: We reviewed the adjuvant chemotherapy regimens before the extended capecitabine in the SYSUCC-001 trial. Patients were classified into “consistent” (standard acceptable dose) and “inconsistent” (doses lower than acceptable dose) dose based on the minimum acceptable dose range in the landmark clinical trials. Cox proportional hazards model was used to investigate the impact of dose on the survival outcomes.Results: All 434 patients in SYSUCC-001 trial were enrolled in this study. Most of patients administered the anthracycline-taxane regimen accounted for 88.94%. Among patients in the “inconsistent” dose, 60.8% and 47% received lower doses of anthracycline and taxane separately. In the observation group, the “inconsistent” dose of anthracycline and taxane did not affect DFS compared with the “consistent” dose. Moreover, in the capecitabine group, the “inconsistent” anthracycline dose did not affect DFS compared with the “consistent” dose. However, patients with “consistent” taxane doses benefited significantly from extended capecitabine (P=0.014). The sufficient dose of adjuvant taxane had a positive effect of extended capecitabine (hazard ratio [HR] 2.04; 95% confidence interval [CI] 1.02 to 4.06).Conclusion: This study found the dose reduction of adjuvant taxane might negatively impact the efficacy of capecitabine. Therefore, the reduction of anthracycline dose over paclitaxel should be given priority during conventional adjuvant chemotherapy, if patients need dose reduction and plan for extended capecitabine.Keywords: adjuvant chemotherapy, capecitabine, SYSUCC-001, triple-negative breast cancer, TNBC
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- 2024
16. Utilization of Nitrogen-Doped Graphene Quantum Dots to Neutralize ROS and Modulate Intracellular Antioxidant Pathways to Improve Dry Eye Disease Therapy
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Wu Z, Xia W, Ou L, Zheng L, Hou B, Pan T, Sun W, Koole LH, Shao Y, and Qi L
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dry eye disease ,antioxidant ,nitrogen doped graphene quantum dots ,nrf2 antioxidant pathway. ,Medicine (General) ,R5-920 - Abstract
Zixia Wu,1,* Weibo Xia,1,* Liling Ou,1 Ling Zheng,1 Bingying Hou,1 Tonghe Pan,2 Wenjie Sun,1 Leo H Koole,1 Yongqing Shao,2 Lei Qi1 1National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, the People’s Republic of China; 2Ningbo Eye Hospital, Affiliated to Wenzhou Medical University, Ningbo, Zhejiang, 310000, the People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongqing Shao, Ningbo Eye Hospital, Affiliated to Wenzhou Medical University, Ningbo, Zhejiang, 310000, the People’s Republic of China, Tel +86-574 87862193, Email sunniesyq@163.com Lei Qi, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, the People’s Republic of China, 325027, Tel +86-577-88067973, Email imdoll@163.comPurpose: Patients afflicted with dry eye disease (DED) experience significant discomfort. The underlying cause of DED is the excessive accumulation of ROS on the ocular surface. Here, we investigated the nitrogen doped-graphene quantum dots (NGQDs), known for their ROS-scavenging capabilities, as a treatment for DED.Methods: NGQDs were prepared by using citric acid and urea as precursors through hydrothermal method. The antioxidant abilities of NGQDs were evaluated through: scavenging the ROS both extracellular and intracellular, regulating the nuclear factor-erythroid 2-related factor (Nrf2) antioxidant pathway of human corneal epithelial cells (HCECs) and their transcription of inflammation related genes. Furthermore, NGQDs were modified by Arg-Gly-Asp-Ser (RGDS) peptides to obtain RGDS@NGQDs. In vivo, both the NGQDs and RGDS@NGQDs were suspended in 0.1% Pluronic F127 (w/v) and delivered as eye drops in the scopolamine hydrobromide-induced DED mouse model. Preclinical efficacy was compared to the healthy and DPBS treated DED mice.Results: These NGQDs demonstrated pronounced antioxidant properties, efficiently neutralizing free radicals and activating the intracellular Nrf2 pathway. In vitro studies revealed that treatment of H2O2-exposed HCECs with NGQDs induced a preservation in cell viability. Additionally, there was a reduction in the transcription of inflammation-associated genes. To prolong the corneal residence time of NGQDs, they were further modified with RGDS peptides and suspended in 0.1% Pluronic F127 (w/v) to create RGDS@NGQDs F127 eye drops. RGDS@NGQDs exhibited superior intracellular antioxidant activity even at low concentrations (10 μg/mL). Subsequent in vivo studies revealed that RGDS@NGQDs F127 eye drops notably mitigated the symptoms of DED mouse model, primarily by reducing ocular ROS levels.Conclusion: Our findings underscore the enhanced antioxidant benefits achieved by modifying GQDs through nitrogen doping and RGDS peptide tethering. Importantly, in a mouse model, our novel eye drops formulation effectively ameliorated DED symptoms, thereby representing a novel therapeutic pathway for DED management.Keywords: dry eye disease, antioxidant, nitrogen doped graphene quantum dots, Nrf2 antioxidant pathway
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- 2024
17. Observation of non-trivial topological electronic structure of orthorhombic SnSe
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Zheng, H. J., Shi, W. J., Wang, C. W., Lv, Y. Y., Xia, W., Li, B. H., Wu, F., He, S. M., Huang, K., Cui, S. T., Chen, C., Yang, H. F., Liang, A. J., Wang, M. X., Sun, Z., Yao, S. H., Chen, Y. B., Guo, Y. F., Mi, Q. X., Yang, L. X., Bahramy, M. S., Liu, Z. K., and Chen, Y. L.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Topological electronic structures are key to the topological classification of quantum materials and play an important role in their physical properties and applications. Recently, SnSe has attracted great research interests due to its superior thermoelectric performance. However, it's topological nature has long been ignored. In this work, by combining synchrotron-based angle-resolved photoemission spectroscopy and ab-initio calculations, we systematically investigated the topological electronic structure of orthorhombic SnSe. By identifying the continuous gap in the valence bands due to the band inversion and the topological surface states on its (001) surface, we establish SnSe as a strong topological insulator. Furthermore, we studied the evolution of the topological electronic structure and propose the topological phase diagram in SnSe1-xTex. Our work reveals the topological non-trivial nature of SnSe and provides new understandings of its intriguing transport properties., Comment: 17 pages, 4 figures, accepted for publication in Physical Review Materials
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- 2022
18. Parent–child interaction, appetite self-regulation, and BMIz in Chinese preschoolers: a mediation analysis
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Xia, W., Xu, K., Wang, M., Chen, H., Wang, Y., Zhou, J., Zheng, B., and Zhang, J.
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- 2024
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19. Risk factors for infection in patients undergoing shoulder arthroscopy: a systematic review and meta-analysis
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Lei, Y., Zeng, Y., Xia, W., Xie, J., Hu, C., Lan, Z., Ma, D., Cai, Y., He, L., Kong, D., Huang, X., Yan, H., Chen, H., Li, Z., and Wang, X.
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- 2024
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20. Development of a Questionnaire for Measuring Trauma-Informed Care of Nurses Working with Traumatically Injured Patients
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Xia W, Wang Y, Wu X, and Yang X
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trauma-informed care ,traumatic injury ,nurse ,questionnaire ,Medicine (General) ,R5-920 - Abstract
Weiping Xia,1,2 Yanbo Wang,1 Xiaoning Wu,1 Xiaojie Yang3 1Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, 200124, People’s Republic of China; 2Department of Surgical Inpatient, United Family Hospital, Shanghai, 200335, People’s Republic of China; 3Department of Orthopedics, Jiangyin Hospital Affiliated to Nantong University, Jiang Yin, 214400, People’s Republic of ChinaCorrespondence: Yanbo Wang, Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center Sciences, School of Medicine, Tongji University, Shanghai, 200124, People’s Republic of China, Email wang_yb@tongji.edu.cnPurpose: To develop a new questionnaire for assessing nurses’ current situation of knowledge, attitude and practice related to trauma-informed care (TIC) for patients with traumatic injury.Methods: By literature review, qualitative interview and Delphi consultation, the 46 preliminary items about trauma-informed care of nurses working with traumatically injured patients were selected. After that, the preliminary questionnaire was distributed to 293 Chinese nurses in relevant departments. The collected data were analyzed by internal reliability, split-half reliability, structural validity and content validity.Results: The questionnaire was developed with a total of 30 items in 3 dimensions: 8 items in the TIC knowledge dimension, 10 items in the TIC attitude dimension and 12 items in the TIC practice dimension. The Cronbach’s alpha coefficient was 0.939, and the content validity was 0.971.Conclusion: This designed questionnaire shews receptable reliability and validity, which could be used to assess the knowledge, attitude and practice of nurses in application of trauma-informed care for traumatically injured patients.Keywords: trauma-informed care, traumatic injury, nurse, questionnaire
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- 2024
21. Cuproptosis-Related lncRNAs Modulate the Prognosis of MIBC by Regulating the Expression Pattern of Immunosuppressive Molecules Within the Tumor Microenvironment
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Duan H, Shen Y, Wang C, Xia W, Zhang S, Yu S, Xu D, Cao Q, Liu H, and Shen H
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cuproptosis-related lncrnas ,immunosuppressive molecules ,mibc ,prognostic ,risk scores ,Medicine (General) ,R5-920 - Abstract
Huangqi Duan,* Yu Shen,* Chen Wang, Weimin Xia, Shun Zhang, Shenggen Yu, Ding Xu, Qifeng Cao, Hailong Liu, Haibo Shen Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Liu; Haibo Shen, Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Email liuhailong@xinhuamed.com.cn; shenhaibo@xinhuamed.com.cnBackground: Cuproptosis-related gene and long non-coding RNA (lncRNA) modulation of cancer regulation is well-established. This investigation aimed to elucidate the prognostic implications of cuproptosis-associated lncRNAs in muscle-invasive bladder cancer (MIBC).Methods: Employing the Cancer Genome Atlas (TCGA) and IMvigor210 cohorts, bioinformatics and statistical analyses probed the prognostic relevance of cuproptosis-related lncRNAs.Results: Co-expression analysis revealed tight associations between lncRNA expression and cuproptosis-linked genes, with 13 cuproptosis-related lncRNAs found to correlate with MIBC prognosis. Lasso regression identified a six-lncRNA prognostic signature, enabling patient stratification into high- and low-risk categories. Tissue validation substantiated differential expression of FAM13A-AS1, GHRLOS, LINC00456, OPA1-AS1, RAP2C-AS1, and UBE2Q1-AS1 between MIBC tumor and normal tissues. Comparative analyses of tumor microenvironments and immune profiles between risk groups disclosed elevated immunosuppressive molecule expression, including programmed cell death-1 (PD-L1) and T-cell immunoglobulin-3 (TIM-3), in high-risk individuals.Conclusion: These findings suggest that cuproptosis-related lncRNAs may modulate the expression of immunosuppressive molecules, thereby influencing MIBC tumorigenesis and progression. Further exploration is warranted to unveil novel therapeutic targets for MIBC based on the expression patterns of cuproptosis-related lncRNAs and their impact on immune responses in the tumor microenvironment.Keywords: cuproptosis-related lncRNAs, immunosuppressive molecules, MIBC, prognostic, risk scores
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- 2024
22. Linking Frontline Employee Self-Efficacy to Customers Service Performance in Healthcare Industry: A Dynamic Capability Perspective
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Li R, Liu J, Xia W, and Ma J
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dynamic environment ,frontline employee ,self-efficacy ,dynamic capability ,service performance ,Public aspects of medicine ,RA1-1270 - Abstract
Rong Li,1 Jing Liu,2 Weidong Xia,3 Jingdong Ma1,4 1School of Medicine and Health Management, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Administrative Office, Yuebei People’s Hospital, Shaoguan, People’s Republic of China; 3Department of Information Systems and Business Analytics, College of Business, Florida International University, Miami, FL, USA; 4Institute for Smart Health Research, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Jingdong Ma, School of Medicine and Health Management, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China, Tel +8613098807808, Email jdma@hust.edu.cnPurpose: In the complex and rapidly changing healthcare environment, the dynamic capabilities of frontline employees (FLEs) to integrate resources and adapt to environmental changes are crucial. This study aims to investigate the relationship between FLEs’ self-efficacy, dynamic capabilities (including sensing capability and reconfiguring capability), and their impact on service performance.Methods: Data were collected from a matched sample of 123 doctors and 762 corresponding consumers from two medical aesthetic hospitals in China. SPSS and SmartPLS are used to test the proposed model.Results: The findings indicate that FLEs’ self-efficacy positively influences their service performance through the mediation of dynamic capabilities. Moreover, while the direct impact of FLEs’ sensing capabilities on service performance was found to be insignificant, it was observed that these capabilities indirectly affect service performance through reconfiguring capabilities.Conclusion: This study presents theories and arguments on the role of self-efficacy and dynamic capabilities in improving service performance. These findings contribute to a deeper understanding of how FLEs cultivate the dynamic capability of resource integration, offering valuable insights for the attainment of sustainable competitive advantages.Keywords: dynamic environment, frontline employee, self-efficacy, dynamic capability, service performance
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- 2023
23. Recombinase Polymerase Amplification-Based Biosensors for Rapid Zoonoses Screening
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Feng X, Liu Y, Zhao Y, Sun Z, Xu N, Zhao C, and Xia W
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recombinase polymerase amplification ,biosensor ,zoonoses ,rapid detection ,nanomaterials ,Medicine (General) ,R5-920 - Abstract
Xinrui Feng,1,2,* Yan Liu,1,* Yang Zhao,3 Zhe Sun,1,4 Ning Xu,5 Chen Zhao,1 Wei Xia4 1College of Public Health, Jilin Medical University, Jilin, 132013, People’s Republic of China; 2Medical College, Yanbian University, Yanji, 136200, People’s Republic of China; 3Department of Emergency and Intensive Medicine, No. 965 Hospital of PLA Joint Logistic Support Force, Jilin, 132013, People’s Republic of China; 4College of Medical Technology, Beihua University, Jilin, 132013, People’s Republic of China; 5State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, 130062, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chen Zhao; Wei Xia, Email zhaochen0115@jlmu.edu.cn; xiawei4016@126.comAbstract: Recent, outbreaks of new emergency zoonotic diseases have prompted an urgent need to develop fast, accurate, and portable screening assays for pathogen infections. Recombinase polymerase amplification (RPA) is sensitive and specific and can be conducted at a constant low temperature with a short response time, making it especially suitable for on-site screening and making it a powerful tool for preventing or controlling the spread of zoonoses. This review summarizes the design principles of RPA-based biosensors as well as various signal output or readout technologies involved in fluorescence detection, lateral flow assays, enzymatic catalytic reactions, spectroscopic techniques, electrochemical techniques, chemiluminescence, nanopore sequencing technologies, microfluidic digital RPA, and clustered regularly interspaced short palindromic repeats/CRISPR-associated systems. The current status and prospects of the application of RPA-based biosensors in zoonoses screening are highlighted. RPA-based biosensors demonstrate the advantages of rapid response, easy-to-read result output, and easy implementation for on-site detection, enabling development toward greater portability, automation, and miniaturization. Although there are still problems such as high cost with unstable signal output, RPA-based biosensors are increasingly becoming one of the most important means of on-site pathogen screening in complex samples involving environmental, water, food, animal, and human samples for controlling the spread of zoonotic diseases. Keywords: recombinase polymerase amplification, biosensor, zoonoses, rapid detection, nanomaterials
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- 2023
24. Measurement of Electronic Structure and Surface Reconstruction in the Superionic Cu2-xTe
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Liu, S., Xia, W., Huang, K., Pei, D., Deng, T., Liang, A. J., Jiang, J., Yang, H. F., Zhang, J., Zheng, H. J., Chen, Y. J., Yang, L. X., Guo, Y. F., Wang, M. X., Liu, Z. K., and Chen, Y. L.
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Condensed Matter - Materials Science - Abstract
Recently, layered copper chalcogenides Cu2X family (X=S, Se, Te) has attracted tremendous research interests due to their high thermoelectric (TE) performance, which is partly due to the superionic behavior of mobile Cu ions, making these compounds phonon liquids. Here, we systematically investigate the electronic structure and its temperature evolution of the less studied single crystal Cu2-xTe by the combination of angle resolved photoemission spectroscopy (ARPES) and scanning tunneling microscope/spectroscopy (STM/STS) experiments. While the band structure of the Cu2-xTe shows agreement with the calculations, we clearly observe a 2 * 2 surface reconstruction from both our low temperature ARPES and STM/STS experiments which survives up to room temperature. Interestingly, our low temperature STM experiments further reveal multiple types of reconstruction patterns, which suggests the origin of the surface reconstruction being the distributed deficiency of liquid-like Cu ions. Our findings reveal the electronic structure and impurity level of Cu2Te, which provides knowledge about its thermoelectric properties from the electronic degree of freedom.
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- 2021
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25. Competing superconductivity and charge-density wave in Kagome metal CsV3Sb5: evidence from their evolutions with sample thickness
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Song, B. Q., Kong, X. M., Xia, W., Yin, Q. W., Tu, C. P., Zhao, C. C., Dai, D. Z., Meng, K., Tao, Z. C., Tu, Z. J., Gong, C. S., Lei, H. C., Guo, Y. F., Yang, X. F., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
Recently superconductivity and topological charge-density wave (CDW) were discovered in the Kagome metals $A$V$_3$Sb$_5$ ($A$ = Cs, Rb, and K), which have an ideal Kagome lattice of vanadium. Here we report resistance measurements on thin flakes of CsV$_3$Sb$_5$ to investigate the evolution of superconductivity and CDW with sample thickness. The CDW transition temperature ${\it T}_{\rm CDW}$ decreases from 94 K in bulk to a minimum of 82 K at thickness of 60 nm, then increases to 120 K as the thickness is reduced further to 4.8 nm (about five monolayers). Since the CDW order in CsV$_3$Sb$_5$ is quite three-dimensional (3D) in the bulk sample, the non-monotonic evolution of ${\it T}_{\rm CDW}$ with reducing sample thickness can be explained by a 3D to 2D crossover around 60 nm. Strikingly, the superconducting transition temperature ${\it T}_{\rm c}$ shows an exactly opposite evolution, increasing from 3.64 K in the bulk to a maximum of 4.28 K at thickness of 60 nm, then decreasing to 0.76 K at 4.8 nm. Such exactly opposite evolutions provide strong evidence for competing superconductivity and CDW, which helps us to understand these exotic phases in $A$V$_3$Sb$_5$ Kagome metals., Comment: 4 pages, 4 figures
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- 2021
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26. Evidence of topological edge states in a superconducting nonsymmorphic nodal-line semimetal
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Xu, L. X., Xia, Y. Y. Y., Liu, S., Li, Y. W., Wei, L. Y., Wang, H. Y., Wang, C. W., Yang, H. F., Liang, A. J., Huang, K., Deng, T., Xia, W., Zhang, X., Zheng, H. J., Chen, Y. J., Yang, L. X., Wang, M. X., Guo, Y. F., Li, G., Liu, Z. K., and Chen, Y. L.
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Condensed Matter - Materials Science - Abstract
Topological materials host fascinating low dimensional gapless states at the boundary. As a prominent example, helical topological edge states (TESs) of two-dimensional topological insulators (2DTIs) and their stacked three-dimensional (3D) equivalent, weak topological insulators (WTIs), have sparked research enthusiasm due to their potential application in the next generation of electronics/spintronics with low dissipation. Here, we propose layered superconducting material CaSn as a WTI with nontrivial Z2 as well as nodal line semimetal protected by crystalline non-symmorphic symmetry. Our systematic angle-resolved photoemission spectroscopy (ARPES) investigation on the electronic structure exhibits excellent agreement with the calculation. Furthermore, scanning tunnelling microscopy/spectroscopy (STM/STS) at the surface step edge shows signatures of the expected TES. These integrated evidences from ARPES, STM/STS measurement and corresponding ab initio calculation strongly support the existence of TES in the non-symmorphic nodal line semimetal CaSn, which may become a versatile material platform to realize multiple exotic electronic states as well as topological superconductivity.
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- 2021
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27. Photoemission Spectroscopic Evidence of Multiple Dirac Cones in Superconducting BaSn$_3$
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Huang, Z., Shi, X. B., Zhang, G. N., Liu, Z. T., Cho, Soohyun, Jiang, Z. C., Liu, Z. H., Liu, J. S., Lu, X. L., Yang, Y. C., Xia, W., Zhao, W. W., Guo, Y. F., and Shen, D. W.
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Condensed Matter - Superconductivity - Abstract
The signatures of topological superconductivity (TSC) in the superconducting materials with topological nontrivial states prompt intensive researches recently. Utilizing high-resolution angle-resolved photoemission spectroscopy and first-principles calculations, we demonstrate multiple Dirac fermions and surface states in superconductor BaSn$_3$ with a critical transition temperature of about 4.4 K. We predict and then unveil the existence of two pairs of type-\uppercase\expandafter{\romannumeral1} topological Dirac fermions residing on the rotational axis. Type-\uppercase\expandafter{\romannumeral2} Dirac fermions protected by screw axis are confirmed in the same compound. Further calculation for the spin helical texture of the observed surface states originating from the Dirac fermions give an opportunity for realization of TSC in one single material. Hosting multiple Dirac fermions and topological surface states, the intrinsic superconductor BaSn$_3$ is expected to be a new platform for further investigation of the topological quantum materials as well as TSC., Comment: 6 pages, 4 figures
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- 2021
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28. Clinical Characteristics of Severe COVID-19 Patients During Omicron Epidemic and a Nomogram Model Integrating Cell-Free DNA for Predicting Mortality: A Retrospective Analysis
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Lu Y, Xia W, Miao S, Wang M, Wu L, Xu T, Wang F, Xu J, Mu Y, Zhang B, and Pan S
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severe covid-19 ,omicron ,clinical characteristics ,mortality ,cfdna ,predicting nomogram ,Infectious and parasitic diseases ,RC109-216 - Abstract
Yanfei Lu,1,2,* Wenying Xia,1,2,* Shuxian Miao,1,2 Min Wang,1,2 Lei Wu,1,2 Ting Xu,1,2 Fang Wang,1,2 Jian Xu,1,2 Yuan Mu,1,2 Bingfeng Zhang,1,2 Shiyang Pan1,2 1Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of China; 2National Key Clinical Department of Laboratory Medicine, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyang Pan, Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Guangzhou Street No. 300, Nanjing, 210029, People’s Republic of China, Tel +8625-6830-6287, Fax +8625-8372-4440, Email sypan@njmu.edu.cnObjective: This study aimed to investigate the clinical characteristics and risk factors of death in severe coronavirus disease 2019 (COVID-19) during the epidemic of Omicron variants, assess the clinical value of plasma cell-free DNA (cfDNA), and construct a prediction nomogram for patient mortality.Methods: The study included 282 patients with severe COVID-19 from December 2022 to January 2023. Patients were divided into survival and death groups based on 60-day prognosis. We compared the clinical characteristics, traditional laboratory indicators, and cfDNA concentrations at admission of the two groups. Univariate and multivariate logistic analyses were performed to identify independent risk factors for death in patients with severe COVID-19. A prediction nomogram for patient mortality was constructed using R software, and an internal validation was performed.Results: The median age of the patients included was 80.0 (71.0, 86.0) years, and 67.7% (191/282) were male. The mortality rate was 55.7% (157/282). Age, tracheal intubation, shock, cfDNA, and urea nitrogen (BUN) were the independent risk factors for death in patients with severe COVID-19, and the area under the curve (AUC) for cfDNA in predicting patient mortality was 0.805 (95% confidence interval [CI]: 0.713– 0.898, sensitivity 81.4%, specificity 75.6%, and cut-off value 97.67 ng/mL). These factors were used to construct a prediction nomogram for patient mortality (AUC = 0.856, 95% CI: 0.814– 0.899, sensitivity 78.3%, and specificity 78.4%), C-index was 0.856 (95% CI: 0.832– 0.918), mean absolute error of the calibration curve was 0.007 between actual and predicted probabilities, and Hosmer-Lemeshow test showed no statistical difference (χ 2=6.085, P=0.638).Conclusion: There was a high mortality rate among patients with severe COVID-19. cfDNA levels ≥ 97.67 ng/mg can significantly increase mortality. When predicting mortality in patients with severe COVID-19, a nomogram based on age, tracheal intubation, shock, cfDNA, and BUN showed high accuracy and consistency.Keywords: severe COVID-19, Omicron, clinical characteristics, mortality, CfDNA, predicting nomogram
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- 2023
29. NUMERICAL CALCULATION OF THE HYDRODYNAMIC CHARACTERISTICS AND STRUCTURAL RESPONSE OF A SUPERSONIC TRUNCATED CONICAL PROJECTILE ENTERING WATER
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Hu, M.-Y., Zhang, S., Xia, W.-X., Meng, Q.-C., and Yi, W.-B.
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- 2023
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30. Secondary infections of COVID-19 in schools and the effectiveness of school-based interventions: a systematic review and meta-analysis
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Zheng, B., Chen, H., Xia, W., Jiang, Y., and Zhang, J.
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- 2024
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31. Double-dome superconductivity under pressure in the V-based Kagome metals AV3Sb5 (A = Rb and K)
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Zhu, C. C., Yang, X. F., Xia, W., Yin, Q. W., Wang, L. S., Zhao, C. C., Dai, D. Z., Tu, C. P., Song, B. Q., Tao, Z. C., Tu, Z. J., Gong, C. S., Lei, H. C., Guo, Y. F., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
We present high-pressure electrical transport measurements on the newly discovered V-based superconductors $A$V$_3$Sb$_5$ ($A$ = Rb and K), which have an ideal Kagome lattice of vanadium. Two superconducting domes under pressure are observed in both compounds, as previously observed in their sister compound CsV$_3$Sb$_5$. For RbV$_3$Sb$_5$, the $T_c$ increases from 0.93 K at ambient pressure to the maximum of 4.15 K at 0.38 GPa in the first dome. The second superconducting dome has the highest $T_c$ of 1.57 K at 28.8 GPa. KV$_3$Sb$_5$ displays a similar double-dome phase diagram, however, its two maximum $T_c$s are lower, and the $T_c$ drops faster in the second dome than RbV$_3$Sb$_5$. An integrated temperature-pressure phase diagram of $A$V$_3$Sb$_5$ ($A$ = Cs, Rb and K) is constructed, showing that the ionic radius of the intercalated alkali-metal atoms has a significant effect. Our work demonstrates that double-dome superconductivity under pressure is a common feature of these V-based Kagome metals., Comment: 5 pages, 4 figures
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- 2021
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32. Nodal superconductivity and superconducting domes in the topological Kagome metal CsV3Sb5
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Zhao, C. C., Wang, L. S., Xia, W., Yin, Q. W., Ni, J. M., Huang, Y. Y., Tu, C. P., Tao, Z. C., Tu, Z. J., Gong, C. S., Lei, H. C., Guo, Y. F., Yang, X. F., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
Recently superconductivity was discovered in the Kagome metal AV3Sb5 (A = K, Rb, and Cs), which has an ideal Kagome lattice of vanadium. These V-based superconductors also host charge density wave (CDW) and topological nontrivial band structure. Here we report the ultralow-temperature thermal conductivity and high pressure resistance measurements on CsV3Sb5 with Tc = 2.5 K, the highest among AV3Sb5. A finite residual linear term of thermal conductivity at zero magnetic field and its rapid increase in fields suggest nodal superconductivity. By applying pressure, the Tc of CsV3Sb5 increases first, then decreases to lower than 0.3 K at 11.4 GPa, showing a clear first superconducting dome peaked around 0.8 GPa. Above 11.4 GPa, superconductivity re-emerges, suggesting a second superconducting dome. Both nodal superconductivity and superconducting domes point to unconventional superconductivity in this V-based superconductor. While our finding of nodal superconductivity puts a strong constrain on the pairing state of the first dome, which should be related to the CDW instability, the superconductivity of the second dome may present another exotic pairing state in this ideal Kagome lattice of vanadium., Comment: 4 figures
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- 2021
33. High prevalence of vertebral deformity in tumor-induced osteomalacia associated with impaired bone microstructure
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Ni, X., Guan, W., Jiang, Y., Li, X., Chi, Y., Pang, Q., Liu, W., Jiajue, R., Wang, O., Li, M., Xing, X., Wu, H., Huo, L., Liu, Y., Jin, J., Zhou, X., Lv, W., Zhou, L., Xia, Y., Gong, Y., Yu, W., and Xia, W.
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- 2023
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34. Dual topological superconducting states in the layered titanium-based oxypnictide superconductor BaTi$_2$Sb$_2$O
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Huang, Z., Liu, W. L., Wang, H. Y., Su, Y. L., Liu, Z. T., Shi, X. B., Gao, S. Y., Jiang, Z. C., Liu, Z. H., Liu, J. S., Lu, X. L., Yang, Y. C., Zhang, J. X., Huan, S. C., Xia, W., Wang, J. H., Wu, Y. S., Wang, X., Yu, N., Huang, Y. B., Qiao, S., Li, J., Zhao, W. W., Guo, Y. F., Li, G., and Shen, D. W.
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Condensed Matter - Superconductivity - Abstract
Topological superconductors have long been predicted to host Majorana zero modes which obey non-Abelian statistics and have potential for realizing non-decoherence topological quantum computation. However, material realization of topological superconductors is still a challenge in condensed matter physics. Utilizing high-resolution angle-resolved photoemission spectroscopy and first-principles calculations, we predict and then unveil the coexistence of topological Dirac semimetal and topological insulator states in the vicinity of Fermi energy ($E_F$) in the titanium-based oxypnictide superconductor BaTi$_2$Sb$_2$O. Further spin-resolved measurements confirm its spin-helical surface states around $E_F$, which are topologically protected and give an opportunity for realization of Majorana zero modes and Majorana flat bands in one material. Hosting dual topological superconducting states, the intrinsic superconductor BaTi$_2$Sb$_2$O is expected to be a promising platform for further investigation of topological superconductivity., Comment: 6 pages, 4 figures
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- 2020
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35. Spectroscopic Signature for Local-moment Magnetism in van der Waals Ferromagnet Fe$_3$GeTe$_2$
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Xu, X., Li, Y. W., Duan, S. R., Zhang, S. L., Chen, Y. J., Kang, L., Liang, A. J., Chen, C., Xia, W., Xu, Y., Malinowski, P., Xu, X. D., Chu, J. -H., Li, G., Guo, Y. F., Liu, Z. K., Yang, L. X., and Chen, Y. L.
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Condensed Matter - Materials Science - Abstract
The van der Waals ferromagnet Fe$_3$GeTe$_2$ has recently attracted extensive research attention due to its intertwined magnetic, electronic and topological properties. Here, using high-resolution angle-resolved photoemission spectroscopy, we systematically investigate the temperature evolution of the electronic structure of bulk Fe$_3$GeTe$_2$. We observe largely dispersive energy bands that are narrowed by a factor of 1.6 compared with ab-initio calculation. Upon heating towards the ferromagnetic transition near 225 K, we observe a massive reduction of quasiparticle coherence in a large energy range, which is attributed to the enhanced magnetic fluctuation in the system. Remarkably, the electron bands barely shift with increasing temperature, which deviates from the exchange splitting picture within the itinerant Stoner model. We argue that the local magnetic moments play a crucial role in the ferromagnetism of Fe$_3$GeTe$_2$, despite its strongly itinerant nature. Our results provide important insights into the electronic and magnetic properties of Fe$_3$GeTe$_2$ and shed light on the generic understanding of itinerant magnetism in correlated materials., Comment: 4 figures
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- 2020
36. Measurement of electronic structure and surface reconstruction in the superionic Cu2-xTe
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Liu, S, Xia, W, Huang, K, Pei, D, Deng, T, Liang, AJ, Jiang, J, Yang, HF, Zhang, J, Zheng, HJ, Chen, YJ, Yang, LX, Guo, YF, Wang, MX, Liu, ZK, and Chen, YL
- Abstract
Recently, layered copper chalcogenides Cu2X family (X=S, Se, Te) has attracted tremendous research interests due to their high thermoelectric performance, which is partly due to the superionic behavior of mobile Cu ions, making these compounds "phonon liquids."Here, we systematically investigate the electronic structure and its temperature evolution of the less studied single crystal Cu2-xTe by the combination of angle resolved photoemission spectroscopy (ARPES) and scanning tunneling microscope/spectroscopy (STM/STS) experiments. While the band structure of the Cu2-xTe shows agreement with the calculations, we clearly observe a 2×2 surface reconstruction from both our low temperature ARPES and STM/STS experiments which survives up to room temperature. Interestingly, our low temperature STM experiments further reveal multiple types of reconstruction patterns, which suggests the origin of the surface reconstruction being the distributed deficiency of liquidlike Cu ions. Our findings reveal the electronic structure and impurity level of Cu2Te, which provides knowledge about its thermoelectric properties from the electronic degree of freedom.
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- 2021
37. Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line
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Wang C, Cao Q, Zhang S, Liu H, Duan H, Xia W, and Shen H
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bladder cancer ,anlotinib ,gsdmb ,targeted therapy ,pyroptosis. ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Chen Wang,1,2 Qifeng Cao,2,* Shun Zhang,2,* Hailong Liu,2 Huangqi Duan,2 Weimin Xia,2 Haibo Shen,2 Cheng Wang1 1Department of Urology, The People’s Hospital of SND, Suzhou, People’s Republic of China; 2Department of Urology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cheng Wang, Department of Urology, The People’s Hospital of SND, Suzhou, People’s Republic of China, Tel +86-15050163288, Email 15050163288@163.com Haibo Shen, Department of Urology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Tel +86-18601712802, Email shenhaibo@xinhuamed.com.cnIntroduction and Objective: The mitogen-activated protein kinase (MAPK) pathway is inhibited by the pan-target inhibitor Anlotinib, which induces tumor cell death. In addition to the common apoptosis and necrosis, there is also a pyroptosis mode of cancer cell death in recent years, which is mainly manifested by the cleavage of gasdermin proteins (GSDMs). Gasdermin B (GSDMB) participates in the progression and outcome of bladder cancer. The efficacy and mechanism of Anlotinib in the treatment of GSDMB-positive bladder tumors have not been studied to date.Methods: The relationship between GSDMB expression and tumor stage, overall survival rate, immunotherapy response, tumor recurrence and progression rate was analyzed from the TCGA bladder cancer database. Anlotinib was used to treat GSDMB-positive bladder cancer in mice followed by flow analysis of the secretion of inflammatory factors related to pyroptosis and the level of anti-tumor factors. Western blot analysis detected which MAPK and MEK signal transduction pathways.Results: TCGA data analysis showed that the overall survival rate of bladder cancer patients with high GSDMB expression was better than that of patients with low GSDMB expression. In vivo experiments showed that Anlotinib was more effective in the treatment of GSDMB-positive bladder cancer than GSDMB-negative bladder cancer. Anlotinib can increase the secretion of antitumor-related factors in GSDMB-positive bladder cancer such as TNF-a and CD107a. In addition, Anlotinib also induced an increase in GSDMB protein expression. Anlotinib treatment of GSDMB-positive bladder cancer decreased AKT and MEK protein expression, which were involved in Anlotinib signal transduction pathway.Conclusion: Anlotinib has a strong antitumor effect on GSDMB-positive bladder tumors. This effect is mainly achieved by anlotinib stimulating the secretion of relevant antitumor factors by lymphocytes. The PI3K/AKT and MEK signal transduction pathways were inhibited by Anlotinib in bladder cancer expressing GSDMB protein.Keywords: bladder cancer, Anlotinib, GSDMB, targeted therapy, pyroptosis
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- 2023
38. Alterations in the Endometrium of Rats, Rabbits, and Macaca mulatta that Received an Implantation of Copper/Low-Density Polyethylene Nanocomposite [Retraction]
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Hu L, Wang H, Rao M, Zhao X, Yang J, Hu S, He J, Xia W, Liu H, Zhen B, Di H, Xie C, Xia X, and Zhu C
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copper/low-density polyethylene nanocomposite ,intrauterine device ,side effects ,endometrium ,Medicine (General) ,R5-920 - Abstract
Hu L, Wang H, Rao M, et al. Int J Nanomedicine. 2014;9(1):1127–1138. We, the Editors and Publisher of International Journal of Nanomedicine, have retracted the following article. Following publication, the authors raised concerns about the duplication of images within the article. Specifically, The images for Figure 4C and 4F have been duplicated, as have the images for Figure 4D and 4E. The images for Figure 6A and 6B have been duplicated, as have the images for Figure 6C and 6D. It was noted that some images for Figures 2 and 10 may have duplicated regions, however, this was caused by an error during the publication process. When approached for an explanation, the authors were cooperative but wereg unable to provide an adequate explanation for the duplicated images and not all the original data for the study was available. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article and the authors agreed with this decision. We have been informed in our decision-making by our editorial policies and COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
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- 2023
39. Persistent gapless surface states in MnBi2Te4/Bi2Te3 superlattice antiferromagnetic topological insulator
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Xu, L. X., Mao, Y. H., Wang, H. Y., Li, J. H., Chen, Y. J., Xia, Y. Y. Y., Li, Y. W., Zhang, J., Zheng, H. J., Huang, K., Zhang, C. F., Cui, S. T., Liang, A. J., Xia, W., Su, H., Jung, S. W., Cacho, C., Wang, M. X., Li, G., Xu, Y., Guo, Y. F., Yang, L. X., Liu, Z. K., and Chen, Y. L.
- Subjects
Condensed Matter - Materials Science - Abstract
Magnetic topological quantum materials (TQMs) provide a fertile ground for the emergence of fascinating topological magneto-electric effects. Recently, the discovery of intrinsic antiferromagnetic (AFM) topological insulator MnBi2Te4 that could realize quantized anomalous Hall effect and axion insulator phase ignited intensive study on this family of TQM compounds. Here, we investigated the AFM compound MnBi4Te7 where Bi2Te3 and MnBi2Te4 layers alternate to form a superlattice. Using spatial- and angle-resolved photoemission spectroscopy, we identified ubiquitous (albeit termination dependent) topological electronic structures from both Bi2Te3 and MnBi2Te4 terminations. Unexpectedly, while the bulk bands show strong temperature dependence correlated with the AFM transition, the topological surface states show little temperature dependence and remain gapless across the AFM transition. The detailed electronic structure of MnBi4Te7 and its temperature evolution, together with the results of its sister compound MnBi2Te4, will not only help understand the exotic properties of this family of magnetic TQMs, but also guide the design for possible applications., Comment: 22 pages, 4 figures
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- 2019
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40. Angle-resolved photoemission spectroscopy study of crystal electric field in heavy fermion compound CePt2In7
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Luo, Yang, Zhang, Chen, Wu, Qi-Yi, Wu, Fan-Ying, Song, Jiao-Jiao, Xia, W., Guo, Yanfeng, Rusz, Jan, Oppeneer, Peter M., Durakiewicz, Tomasz, Zhao, Yin-Zou, Liu, Hao, Zhu, Shuang-Xing, Yuan, Ya-Hua, He, Jun, Tan, Shi-Yong, Huang, Y. B., Sun, Zhe, Liu, Yi, Liu, H. Y., Duan, Yu-Xia, and Meng, Jian-Qiao
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
The three-dimensional electronic structure and Ce 4f electrons of the heavy fermion superconductor CePt2In7 is investigated. Angle-resolved photoemission spectroscopy using variable photon energy establishes the existence of quasi-two and three dimensional Fermi surface topologies. Temperature-dependent 4d-4f on-resonance photoemission spectroscopies reveal that heavy quasiparticle bands begin to form at a temperature well above the characteristic (coherence) temperature T*. T* emergence may be closely related to crystal electric field splitting, particularly the low-lying heavy band formed by crystal electric field splitting., Comment: 6 pages, 4 figures
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- 2019
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41. Pressure-induced superconductivity and topological phase transitions in the topological nodal-line semimetal SrAs3
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Cheng, E. J., Xia, W., Shi, X. B., Yu, Z. H., Wang, L., Yan, L. M., Peets, D. C., Zhu, C. C., Su, H., Zhang, Y., Dai, D. Z., Wang, X., Zou, Z. Q., Yu, N., Kou, X. F., Yang, W. G., Zhao, W. W., Guo, Y. F., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
Topological nodal-line semimetals (TNLSMs) are materials whose conduction and valence bands cross each other, meeting a topologically-protected closed loop rather than discrete points in the Brillouin zone (BZ). The anticipated properties for TNLSMs include drumhead-like nearly flat surface states, unique Landau energy levels, special collective modes, long-range Coulomb interactions, or the possibility of realizing high-temperature superconductivity. Recently, SrAs3 has been theoretically proposed and then experimentally confirmed to be a TNLSM. Here, we report high-pressure experiments on SrAs3, identifying a Lifshitz transition below 1 GPa and a superconducting transition accompanied by a structural phase transition above 20 GPa. A topological crystalline insulator (TCI) state is revealed by means of density functional theory (DFT) calculations on the emergent high-pressure phase. As the counterpart of topological insulators, TCIs possess metallic boundary states protected by crystal symmetry, rather than time reversal. In consideration of topological surface states (TSSs) and helical spin texture observed in the high-pressure state of SrAs3, the superconducting state may be induced in the surface states, and is most likely topologically nontrivial, making pressurized SrAs3 a strong candidate for topological superconductor., Comment: 22 pages, 5 figures
- Published
- 2019
42. A morphological control strategy of γ′ precipitates in nickel-based single-crystal superalloys: an aging design, fundamental principle, and evolutionary simulation
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Xu, J., Zhao, X., Yue, Q., Xia, W., Duan, H., Gu, Y., and Zhang, Z.
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- 2023
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43. IL-37 alleviates intervertebral disc degeneration via the IL-1R8/NF-κB pathway
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Li, S., Pan, X., Wu, Y., Tu, Y., Hong, W., Ren, J., Miao, J., Wang, T., Xia, W., Lu, J., Chen, J., Hu, X., Lin, Y., Zhang, X., and Wang, X.
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- 2023
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44. Preoperative Systemic Inflammatory Markers as a Significant Prognostic Factor After TURBT in Patients with Non-Muscle-Invasive Bladder Cancer
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Ding L, Deng X, Wang K, Xia W, Zhang Y, Shao X, and Wang J
- Subjects
systemic inflammatory markers ,risk factor ,bladder cancer ,nmibc ,tumor recurrence ,nomogram ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Li Ding,1,* Xiaobin Deng,2,* Kun Wang,1,* Wentao Xia,1,* Yang Zhang,1 Yan Zhang,1 Xianfeng Shao,1 Junqi Wang1 1Department of Urology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China; 2Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junqi Wang, Email wangjq_68@163.comIntroduction: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR) have been widely proposed to have predictive value for the patient prognosis of many malignancies, including bladder cancer. However, the predictive value of their combination in non-muscle-invasive bladder cancer (NMIBC) is unclear.Methods: Cases of NMIBC patients who underwent transurethral resection of the bladder tumor were recruited from two tertiary public medical centers. A systemic inflammatory marker (SIM) score was calculated based on comprehensive consideration of NLR, PLR, and LMR. Recurrence-free survival (RFS) and progression-free survival (PFS) were estimated by Kaplan-Meier analysis. The Log rank test was used to compare differences between the groups. Cox regression was used to screen risk factors affecting RFS and PFS. Nomogram models were established and validated, and patients were stratified based on the model scores.Results: The study dataset was grouped according to a 7:3 randomization, with the training cohort consisting of 292 cases and the validation cohort consisting of 124 cases. Cox regression analysis showed that SIM score is an independent predictor of RFS and PFS in NMIBC patients. The novel models were established based on the SIM score and other statistically significant clinicopathological features. The area under the curve (AUC) for predicting 1-, 2-, and 3-year RFS was 0.667, 0.689, and 0.713, respectively. The AUC for predicting 1-, 2-, and 3-year PFS was 0.807, 0.775, and 0.862, respectively. Based on the risk stratification, patients at high risk of recurrence and progression could be accurately identified. The established models were applied to the patient evaluation of the validation cohort, which proved the great performance of the novel models.Conclusion: The novel models based on the SIM score and clinicopathological characteristics can accurately predict the survival prognosis of NMIBC patients, and the models can be used by clinicians for individualized patient assessment and to assist in clinical decision-making.Keywords: systemic inflammatory markers, risk factor, bladder cancer, NMIBC, tumor recurrence, nomogram
- Published
- 2023
45. Correlation of serum DKK1 level with skeletal phenotype in children with osteogenesis imperfecta
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Wang, Y., primary, Hu, J., additional, Sun, L., additional, Zhou, B., additional, Lin, X., additional, Zhang, Q., additional, Wang, O., additional, Jiang, Y., additional, Xia, W., additional, Xing, X., additional, and Li, M., additional
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- 2024
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46. Bone microarchitecture impairment in prolactinoma patients assessed by HR-pQCT
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Wang, L., Chen, K., Duan, L., Ke, X., Gong, F., Pan, H., Yang, H., Zhu, H., and Xia, W.
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- 2022
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47. The efficacy and safety of different doses of calcitriol combined with neutral phosphate in X-linked hypophosphatemia: a prospective study
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Jin, C., Zhang, C., Ni, X., Zhao, Z., Xu, L., Wu, B., Chi, Y., Jiajue, R., Jiang, Y., Wang, O., Li, Mei, Xing, X., Meng, X., and Xia, W.
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- 2022
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48. Nomogram Based on Clinical and Radiomics Data for Predicting Radiation-induced Temporal Lobe Injury in Patients with Non-metastatic Stage T4 Nasopharyngeal Carcinoma
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Bin, X., Zhu, C., Tang, Y., Li, R., Ding, Q., Xia, W., Tang, X., Yao, D., and Tang, A.
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- 2022
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49. Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study
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Zhang X, Jin F, Lu Y, Ni F, Xu Y, and Xia W
- Subjects
infective endocarditis ,clinical characteristics ,risk factors ,elderly patients ,Infectious and parasitic diseases ,RC109-216 - Abstract
Xiaohui Zhang,1,2,* Fei Jin,1,2,* Yanfei Lu,1,2 Fang Ni,1,2 Yuqiao Xu,1,2 Wenying Xia1,2 1Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of China; 2Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuqiao Xu; Wenying Xia, Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Street No. 300, Guangzhou, 210029, People’s Republic of China, Tel +8625-6830-6146 ; +8625-6830-6287, Fax +8625-8372-4440, Email joe8165@163.com; xiawenying21106891@163.comPurpose: This study aimed (i) to investigate the clinical characteristics and risk factors related to in-hospital mortality in patients with infective endocarditis (IE) and (ii) to compare the differences in three age groups.Methods: A total of 240 IE cases diagnosed using the modified Duke criteria between January 2016 and December 2019 were included and retrospectively studied. Patients were stratified into three age groups: < 50 y, 50– 65 y, and > 65 y.Results: The mean age of the patients was 51 ± 14 y, and 154 patients (64.2%) were male. In addition, 136 (56.7%) patients with IE had no previous cardiac disease. Congenital heart disease (CHD, 21.3%) was the most common underlying heart disease, followed by rheumatic heart disease (RHD, 8.8%). Streptococcus was found in 55 (22.9%) patients and was the most common causative pathogen, comprising 52.9% of all positive blood cultures. Echocardiography showed the presence of vegetations in 88.3% of cases and the predominant involvement of the left heart valves. Fever and cardiac murmur were the most frequent presentations, with no significant differences among age groups. Compared with younger patients, elderly patients had a lower operation rate and higher in-hospital mortality. The independent risk factors of in-hospital mortality were age > 65 y, intracranial infection, splenic embolization, cerebral hemorrhage, NYHA class III–IV, and prosthetic valve infection.Conclusion: CHD replaces RHD as the most common underlying heart disease in IE patients. Patients without previous cardiac disease are at increased risk of IE. Streptococcus is still the primary causative pathogen of IE. Elderly patients present with more comorbidities and complications, in addition to a more severe prognosis than younger patients. Age older than 65 y, intracranial infection, splenic embolization, cerebral hemorrhage, NYHA class III–IV, and prosthetic valve infection showed poorer in-hospital outcomes.Keywords: infective endocarditis, clinical characteristics, risk factors, elderly patients
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- 2022
50. Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection
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Shen H, Fu Y, Chen Y, Xia W, Jia ZJ, Yu Q, Zhang L, and Han L
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compatibility ,stability ,pediatric electrolyte supplements injection ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Hongxin Shen,1– 3 Yuzhi Fu,1– 3 Ying Chen,1– 3 Wenxing Xia,1– 3 Zhi-Jun Jia,1– 4 Qin Yu,3,5 Lingli Zhang,1– 3 Lu Han1– 3 1Department of Pharmacy, West China Second University Hospital of Sichuan University, Chengdu, People’s Republic of China; 2Evidence-Based Pharmacy Center, West China Second University Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, People’s Republic of China; 4West China School of Pharmacy, Sichuan University, Chengdu, People’s Republic of China; 5Institute of Drug Clinical Trial GCP, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Lu Han, West China Second University Hospital, Sichuan University, No. 20, Third Section, Renmin South Road, Chengdu, Sichuan, 610041, People’s Republic of China, Email luhan830301@sina.comObjective: Pediatric electrolyte supplements injection is mainly used to supplement heat and body fluid, and commonly used in pediatrics. Its compatibility and stability with common clinical drugs such as antibiotics was rarely reported to ensure the children’s safety and the rational use of drugs. The aim of the present study was to investigate physical and chemical stability of pediatric electrolyte supplements injection mixed with ten commonly used clinical drugs.Methods: According to clinical drug concentration, we mix the pediatric electrolyte supplements injection mixed with ten drugs. The compatible solutions were withdrawn at certain time intervals (0, 0.5, 1, 2, 4, 6 hours) after mixing and tested by description, insoluble particles detection, pH determination and high performance liquid chromatography (HPLC) assay of active ingredient as measures of physicochemical compatibility.Results: No obvious appearance changes were observed when mixing. Furthermore, over the 6 hours post-preparation period the pH values were within the requirements of each drug quality standard and the number of insoluble particles (≥ 10 and ≥ 25μm) met requirements of Chinese Pharmacopeia (Edition 2020) except for mezlocillin sodium for injection. The percentages of the initial concentrations maintained at a minimum of 97% in the mixtures within 6 hours.Conclusions: Nine commonly used clinical drugs remained stable in the pediatric electrolyte supplements injection for 6 hours at 25°C and avoiding from light. Mezlocillin sodium for injection was not recommended to be combined with electrolyte supplement injection for children because its insoluble particles exceed the standard.Keywords: compatibility, stability, pediatric electrolyte supplements injection
- Published
- 2022
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