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Real-time train rescheduling for high-speed railway (HSR) is a pivotal technique in HSR transportation to efficiently recover train operation under disturbance scenarios. This paper aims to put forward an integrated resolving and rescheduling method considering network delay propagation. A tree-based conflict resolution mechanism is first established, with delicate considerations on the strategy's adaptability under different conflict scenarios. By inputting the scheduled arrival and departure time under different conflict resolution strategies, the timetable optimizing model aims to look for an optimal solution with minimal weighted train delay and average train adjustments under necessary technical and empirical constraints solved by a combined algorithm of Pareto optimality and Nash equilibrium, where the feasible solution space is narrowed in advance by a depth-first pruning algorithm. The performance of this coordinated train rescheduling approach is validated by a typical section disturbance in a regional HSR network administrated by the Shanghai Bureau. The results show that the proposed method can well utilizes timetable buffers and organizes train avoidance. The delay propagation characteristics are also simultaneously estimated based on the indicators of cumulative delay and instantaneous delay, which are established considering the spatio-temporal difference between the scheduled and planned timetables, in order to verify the coordination between resolution strategies and train running delays., Author(s): Jun Zhang (corresponding author) [1]; Shuyao Wu [1]; Shejun Deng [1]; Yuling Ye [2] 1. Introduction Under the network transportation of high-speed railway (HSR), disturbances of abnormal events are [...]

Obesity has now surpassed malnutrition and infectious diseases as the most significant contributor to health problems worldwide. In particular, obesity is associated with several metabolic disorders, including hyperlipidemia, hepatic steatosis, and subfertility. Genipin (GNP), the aglycone of geniposide, is isolated from the extract of the traditional Chinese medicine Gardenia jasminoides Ellis and has been used in traditional oriental medicine against several inflammation-driven diseases. However, the effect and molecular mechanism of GNP on obesity-associated dyslipidemia and sperm dysfunction still need to be explored. In this study, we detect the effects of GNP on hyperlipidemia, hepatic lipid accumulation and sperm function using a high-fat diet (HFD)-induced obese mouse model. We find that obese mice treated with GNP show an improvement in body weight, serum triglyceride levels, serum hormone levels, serum inflammatory cytokines, hepatic steatosis and sperm function. At the molecular level, HFD/GNP diversely regulates the expression of miR-132 in a tissue-specific manner. miR-132 further targets and regulates the expression of SREBP-1c in liver cells, as well as the expressions of SREBP-1c and StAR in Leydig cells in the testis, thus modifying lipogenesis and steroidogenesis, respectively. Collectively, our data demonstrate that GNP shows a broad effect on the improvement of HFD-induced metabolic disorder and sperm dysfunction in male mice by tissue-specific regulation of miR-132. Our findings reveal the function GNP in ameliorating hepatic lipid metabolism and sperm function and suggest that this compound is a versatile drug to treat metabolic disorders.

The effect of anions on the positive electrospray ionization (ESI) of proteins in different strong acids with varying pH values from 3 to 1 is studied using high-pressure ESI. Reducing the pH from ∼2 to 1 caused a drastic shift in charge state from a high-charge-state distribution (HCSD) to a narrow low-charge-state distribution (LCSD). The shift in charge state was consistent with the circular dichroism result that showed a conformational change due to the "acid-induced folding" of proteins from an unfolding state to a compact molten globule state. Acids of different anions produced noticeable differences in the average charge for HCSD and LCSD. For HCSD, the average charge was lower than the value typically observed using formic and acetic acids. As for LCSD, the average charge was lower than the "native" charge. The high abundance of acid anion that induces the protein compaction was believed to play a role in charge reduction. The effectiveness of anions to "refold" a highly unfolded protein to a compact state and the propensity to reduce the charge of HCSD for proteins appeared to follow the selectivity series of anions towards the stationary phase in ion chromatography. However, the propensity of anions to reduce the charge for LCSD follows quite an opposite trend. The presence of ammonium salt in the acidic solution was found to increase the charge of LCSD. The simple mass spectrum with a narrow distribution of charge state obtained with perchloric acid at pH 1 was demonstrated to facilitate the counting of basic sites. [ABSTRACT FROM AUTHOR]

Considering the complex construction processes involved, there are significant risks during the construction of long-span cantilever casting arch bridges. In this study, a risk assessment method for the construction process of cantilever casting concrete arch bridges was developed. The compositional elements and characteristics of safety risks in the construction of cantilever casting concrete arch bridges were clarified, and a safety risk source list that includes seven major risk sources and thirty-three minor risk sources was formed. Then, a Bayesian model for the risk analysis of cantilever casting concrete arch bridge construction was established, and a method was proposed to determine the prior and posterior probabilities of the Bayesian network using triangular fuzzy numbers. This method fully utilizes the experience of experts while avoiding the subjectivity of expert opinions. A cantilever casting concrete open spandrel arch bridge (Bridge A) with a total span length of 287 m was taken as an example, and a safety risk assessment was conducted during its construction process. The calculation results show that the construction safety risk level of Bridge A was level III. This engineering application verified the feasibility of determining key node parameters of the Bayesian network using triangular fuzzy numbers. [ABSTRACT FROM AUTHOR]

For decades, China has implemented restoration programs on a large scale, thanks to its capacity to set policy and mobilize funding resources. An understanding of China's restoration achievements and remaining challenges will help to guide future efforts to restore 30% of its diverse ecosystems under the Kunming-Montreal Global Biodiversity Framework. Here we summarize the major transitions in China's approach to ecosystem restoration since the 1970s, with a focus on the underlying motivations for restoration, approaches to ecosystem management, and financing mechanisms. Whereas China's restoration efforts were predominantly guided by the delivery of certain ecosystem functions and services in earlier decades, more recently it has come to emphasize the restoration of biodiversity and ecosystem integrity. Accordingly, the focal ecosystems, approaches, and financing mechanisms of restoration have also been considerably diversified. This evolution is largely guided by the accumulation of scientific evidence and past experiences. We highlight the key challenges facing China's restoration efforts and propose future directions to improve restoration effectiveness, with regard to goal setting, monitoring, stakeholder involvement, adaptive management, resilience under climate change, and financing. China has been engaged in ecosystem restoration efforts for decades, but recent changes in what defines 'restoration' call for new approaches. In this essay, Li et al. highlight China's previous ecosystem restoration achievements and the changes needed to restore its diverse ecosystems under the Kunming-Montreal Global Biodiversity Framework. [ABSTRACT FROM AUTHOR]

This article discusses the development of a novel pH probe called Mem-C0C18 for quantitative monitoring of cell surface pH using fluorescence lifetime imaging. The surface pH of tumor cells is lower than that of normal cells due to the production of acidic metabolites. The probe targets the plasma membrane and accurately measures pH changes using fluorescence lifetime imaging. The article provides details on the molecular design of the probe, its spectral properties, establishment of standard curves, and its application in evaluating the effects of extracellular fluid acidity and glycolysis on cell surface pH. The probe shows promise as a tool for studying pH fluctuations in the cell membrane. [Extracted from the article]

Droughts have been implicated as the main driver behind recent vegetation die‐off and are projected to drive greater mortality under future climate change. Understanding the coupling relationship between vegetation and drought has been of great global interest. Currently, the coupling relationship between vegetation and drought is mainly evaluated by correlation coefficients or regression slopes. However, the optimal drought timescale of vegetation response to drought, as a key indicator reflecting vegetation sensitivity to drought, has largely been ignored. Here, we apply the optimal drought timescale identification method to examine the change in coupling between vegetation and drought over the past three decades (1982–2015) with long‐term satellite‐derived Normalized Difference Vegetation Index and Standardized Precipitation‐Evapotranspiration Index data. We find substantial increasing response of vegetation to drought timescales globally, and the correlation coefficient between vegetation and drought under optimal drought timescale overall declines between 1982 and 2015. This decrease in vegetation–drought coupling is mainly observed in regions with water deficit, although its initial correlation is relatively high. However, vegetation in water‐surplus regions, with low coupling in earlier stages, is prone to show an increasing trend. The observed changes may be driven by the increasing trend of atmospheric CO2. Our findings highlight more pressing drought risk in water‐surplus regions than in water‐deficit regions, which advances our understanding of the long‐term vegetation–drought relationship and provides essential insights for mapping future vegetation sensitivity to drought under changing climate conditions. [ABSTRACT FROM AUTHOR]

Pickering emulsion interfacial catalysis (PEIC) could be a feasible strategy to improve the efficiency of catalytic reactions, but it is difficult to achieve in hot conditions because conventional Pickering emulsions are unstable at high temperatures. Herein, a stable hot Pickering emulsion interfacial catalysis (HPEIC) system for efficient depolymerization of polyethylene terephthalate (PET) was constructed by using modified asymmetric nanonets (M-ANNs), a super-performance emulsifier that we have reported. In the HPEIC system, biphenyl that can disperse PET is chosen to be the dispersed phase, and ethylene glycol that can dissolve glycolysis catalyst Zn(OAc)2 is designed as the continuous phase. The HPEIC system achieved 100% depolymerization of PET and yielded more than 90% of PET monomer within 5 minutes at 170 °C, due to the suitably designed respective dissolution of PET and Zn(OAc)2 in the two different solvents, the large emulsion interface area, and the enrichment of catalyst at the emulsion droplets interface. The degradation time is extremely shortened and the reaction temperature is at least 20 °C lower than that of the traditional homogeneous catalytic systems. The HPEIC system maintained a high PET depolymerization rate after six times of recycles. [ABSTRACT FROM AUTHOR]